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PRG3 — TNF

Text-mined interactions from Literome

Horiguchi et al., Cytokine 2000 : TNF-alpha ( 10 ng/ml ) stimulated [ 3H ] thymidine incorporation in undifferentiated ATDC5 cells, and suppressed cartilaginous nodule formation and the accumulation of cartilage-specific proteoglycan
Long et al., Arthritis Rheum 2001 (Inflammation) : Additionally, CTS augments the reparative process via abrogation of TNFalpha induced suppression of proteoglycan synthesis
Mastbergen et al., Rheumatology (Oxford) 2002 : Both PBMC and IL-1beta plus TNF-alpha induced strong inhibition of cartilage proteoglycan synthesis and significant enhancement of the release of proteoglycans, diminishing proteoglycan content
Sabatini et al., Osteoarthritis Cartilage 2002 : PPAR agonists 15d-PGJ ( 2 ) and GI262570 ( 10 microM ) inhibited IL-1beta- and TNFalpha induced proteoglycan degradation measured both before and after addition of APMA
Fermor et al., Osteoarthritis Cartilage 2004 : TNF-alpha prevented the mechanical stimulation of proteoglycan synthesis, and this effect was not dependent on NOS2
Wilbrink et al., Br J Rheumatol 1991 : In both young and old human articular cartilage explants, TNF alpha induced a concentration dependent, reversible suppression of the proteoglycan ( PG ) synthesis
Malfait et al., Osteoarthritis Cartilage 2009 (Arthritis, Experimental...) : Indomethacin, dexamethasone, and an aggrecanase inhibitor were evaluated for their ability to modulate TNFalpha induced proteoglycan degradation in vivo
Ye et al., J Huazhong Univ Sci Technolog Med Sci 2011 (Intervertebral Disc Degeneration...) : The result showed that TNF-a increased the expression of ß-catenin and MMP-13, and significantly inhibited the synthesis of type II collagen and proteoglycan , which resulted in the degeneration of nucleus pulposus cells
Kowanko et al., Rheumatol Int 1990 (Cartilage Diseases) : Recombinant human TNF alpha enhanced neutrophil mediated degradation of proteoglycan , even when neutrophils were preincubated with TNF alpha and washed before incubating with cartilage
Pratta et al., Agents Actions 1989 : IL-1, 1 to 100 ng/ml, and TNF , 10 to 1,000 ng/ml, increased proteoglycan degradation
Saklatvala et al., J Rheumatol 1987 : Tumor necrosis factor also has been shown to cause similar cartilage degradation and both cytokines inhibit resynthesis of proteoglycan
Saklatvala et al., Nature 1986 : I report here that recombinant human TNF alpha stimulates resorption and inhibits synthesis of proteoglycan in explants of cartilage
Ramasamy et al., J Cell Physiol 1995 : Tumor necrosis factor reduces proteoglycan synthesis in cultured endothelial cells
Hardingham et al., Rev Rhum Ed Fr 1994 : IL-1 alpha, beta and TNF alpha inhibit proteoglycan synthesis and at slightly higher concentration they enhance the rates of matrix degradation
Yocum et al., Arch Biochem Biophys 1995 : Tumor necrosis factor-alpha and retinoic acid also stimulated proteoglycan degradation in chondrocyte monolayers, and in both cases the response was inhibited by bafilomycin A1
Yeh et al., J Rheumatol 1995 : IL-4 significantly reduced the cartilage proteoglycan degradation induced by IL-1 alpha, TNF-alpha , TNF-alpha plus IL-1 alpha, or LPS ( 50 % inhibitory concentration, IC50 for IL-4 ranged from about 15 to 50 ng/ml )
Bustos et al., Clin Exp Immunol 1995 (Nephrosis) : CsA also reversed the inhibitory effect of PAF and TNF-alpha on proteoglycan synthesis
Van Lent et al., J Rheumatol 1995 (Arthritis, Experimental...) : To determine the regulating role of interleukin-1 alpha and beta ( IL-1 alpha, beta ) and tumor necrosis factor alpha (TNF-alpha) on inhibition of proteoglycan synthesis and proteoglycan degradation in early immune complex arthritis ( ICA ) in the mouse
Bryson et al., Arch Biochem Biophys 1998 : It potently inhibited interleukin 1- and tumor necrosis factor stimulated proteoglycan release from both nasal and articular cartilage