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IL1B — TNF
Text-mined interactions from Literome
Hirji et al., Int Arch Allergy Immunol 1999
:
In addition, Ro 31-8220 ( a PKC inhibitor ) inhibited OX8 induced iNOS upregulation, NO and
IL-1beta production, but did not
inhibit TNF-alpha production
Pampfer et al., Cytokine 1999
(Hyperglycemia) :
Interleukin 1beta mediates the effect of high D-glucose on the secretion of
TNF-alpha by mouse uterine epithelial cells
Qiu et al., Zhongguo Yao Li Xue Bao 1999
:
SMT inhibited LPS induced nitric oxide release and
increased IL-1 beta and IL-6 secretions in AM, but the
TNF alpha levels remained unchanged
Van bezooijen et al., J Bone Miner Res 1999
(Bone Resorption) :
In addition, IL-17 increased
TNF-alpha induced IL-1alpha,
IL-1beta , and IL-6 mRNA expression in fetal mouse metatarsals and IL-1alpha and IL-6 mRNA expression in MC3T3-E1 cells
Takayama et al., J Invest Dermatol 1999
:
Both GM-CSF and
TNF-alpha induced the migration of human Langerhans cells in vitro, whereas
IL-1beta , IL-2, IL-10, IL-12, and IFN-gamma had no effect on Langerhans cell migration
Yang et al., J Cereb Blood Flow Metab 1999
(Arterial Occlusive Diseases...) :
To investigate the
role of
IL- 1beta in regulation of
tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 ( ICAM-1 ) during focal cerebral ischemia, the authors studied mutant mice deficient in the IL-1 converting enzyme (ICE) gene ( ICE knockout [ KO ] mice )
Ranta et al., Crit Care Med 1999
:
Unstimulated HUVECs did not produce detectable amounts of TNF-alpha, but IFN-gamma,
IL-1beta , and LPS when added together
induced TNF-alpha production of HUVECs in a time dependent manner ... IFN-gamma,
IL-1beta , or LPS alone did not
induce TNF-alpha production, whereas IFN-gamma and IL-1beta in combination were able to induce TNF-alpha production to some extent, and the production could be further increased with LPS
Arima et al., Am J Respir Cell Mol Biol 1999
(Asthma...) :
BEAS-2B constitutively expressed IL-16 messenger RNA ( mRNA ) and protein ; IL-16 expression was significantly upregulated in a concentration dependent manner within 24 h by stimulation with histamine,
IL-1beta , or
tumor necrosis factor (TNF)-alpha whereas interferon-gamma did not significantly
increase IL-16
Huang et al., Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital 1999
:
The spontaneous or IFN-gamma
+TNF-alpha +IL-1 beta induced IL-8 release was significantly augmented after the addition of neutrophils
Isumi et al., FEBS Lett 1999
:
Adrenomedullin suppresses
interleukin-1beta induced
tumor necrosis factor-alpha production in Swiss 3T3 cells ... We demonstrated that adrenomedullin (AM) inhibited
interleukin-1beta induced
tumor necrosis factor-alpha (TNF-alpha) secretion and gene transcription in Swiss 3T3 fibroblasts maximally to 23 % and 18 % of control, while the other peptides elevating intracellular cAMP levels elicited much weaker effects
Kwak et al., Infect Immun 2000
(Streptococcal Infections) :
In contrast to the response to LPS, where
TNF-alpha , IL-1beta, IL-6, and IL-8 appear almost simultaneously, the human monocyte response to GBS results in the production of TNF-alpha but
delayed appearance of
IL-1beta , IL-6, and IL-8
Pouliot et al., J Periodontal Res 1999
(Periodontal Diseases) :
At nanomolar levels, the LXA4 and ATL analog 15 R/S-methyl-LXA4 each blocked
TNF alpha stimulated
IL-1 beta release by isolated human PMN in vitro ... The
TNF alpha induced
IL-1 beta gene expression was also regulated by 15 R/S-methyl-LXA4
Denizot et al., Cytokine 2000
:
Addition of IL-4, but not IL-10 or TGF-beta, reduces the
TNF-alpha induced cell associated
IL-1beta ... In conclusion the pro-inflammatory molecule
TNF-alpha stimulates bone marrow stromal cell associated
IL-1beta levels while the anti-inflammatory cytokine IL-4 reduces the TNF-alpha induced effect
Liu et al., J Neurosci 2000
:
Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP ( oATP ), resulted in a significant downregulation of
IL-1beta stimulated expression of nitric oxide,
tumor necrosis factor ( TNFalpha ), and IL-6 at both the protein and mRNA levels, without affecting cell viability
Call et al., Gen Comp Endocrinol 2000
:
The release of IL-6 and
TNF from the ZG, ZF, ZR, and medulla was
increased by PDB, IL-1alpha,
IL-1beta , and LPS
Song et al., Am J Physiol Lung Cell Mol Physiol 2000
:
However, the LPS effects on
TNF-alpha and IL-8 are
inhibited by < 20 % and the effect on
IL-1beta by < 50 %. Third, at Survanta levels of 1 mg/ml, SP-A induced responses are reduced by > 90 %, and although the inhibitory effects on LPS action increase, they still do not reach those seen with SP-A
Tummala et al., J Mol Cell Cardiol 2000
:
DPI also inhibited
TNF and LPS induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha, LPS, or
IL-1 beta induced VCAM-1 and ICAM-1 mRNA accumulation
Tomita et al., Gene Ther 2000
(Glomerulonephritis) :
Therefore, we examined the effect of NFkappaB decoy ODN transfection on
TNF-alpha induced endogenous interleukin (IL)-1alpha,
IL-1beta , IL-6, ICAM-1 and VCAM-1 gene expression as assessed by RT-PCR and Northern blotting
Obara et al., Arterioscler Thromb Vasc Biol 2000
(Arteriosclerosis) :
In cells overexpressing IkappaBDeltaN,
TNF-alpha dramatically
induced apoptosis, whereas
IL-1beta had no effect
Han et al., J Gerontol A Biol Sci Med Sci 2000
(Orthomyxoviridae Infections...) :
Pulmonary interleukin (IL)-6,
IL-1beta , and
tumor necrosis factor (TNF)-alpha levels
increased significantly postinfection
Baur et al., J Endocrinol 2000
:
In reaggregate cultures of rat anterior pituitaries
IL-1 beta stimulated D1 and D2 dose-dependently and D2 activity was
increased by
TNF alpha
Chowers et al., Gastroenterology 2001
(Enteritis) :
Spontaneous and
tumor necrosis factor (TNF)-alpha stimulated interleukin (IL)-8 and
IL-1 beta secretion and mRNA expression were assessed in HT-29 and Caco-2 intestinal epithelial cell lines in the presence of a panel of heparin and heparan sulfate disaccharides
Arrighi et al., J Immunol 2001
(Dermatitis, Allergic Contact) :
Likewise, SB203580 partially prevented the up-regulation of IL-1alpha,
IL-1beta , IL-lRa, and TNF-alpha mRNA upon
stimulation with LPS and
TNF-alpha , as well as the release of bioactive TNF-alpha induced by LPS
Jiang et al., Chin Med Sci J 1997
(Shock, Hemorrhagic) :
The results were : 1. expression of TNF alpha, IL-1 beta, IL-6 mRNA in vital organs successively increased after hemorrhagic shock and resuscitation, and
TNF alpha expression was the first to appear
followed by
IL-1 beta
Lindström et al., Eur J Pharmacol 2001
:
Isolated rat stomach ECL cells generate prostaglandin E ( 2 ) in
response to
interleukin-1 beta ,
tumor necrosis factor-alpha and bradykinin
Zhang et al., J Clin Endocrinol Metab 2001
:
Dexamethasone inhibits
tumor necrosis factor-alpha induced apoptosis and
interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes ...
TNF alpha increased the messenger ribonucleic acid levels of ICE, TNF alpha,
IL-1 beta , bcl-2, and NF kappa B in preadipocytes and adipocytes ( P < 0.01 ) ... Dex inhibited
TNFalpha induced messenger ribonucleic acid expression of ICE, TNF alpha, and
IL-1 beta ( P < 0.01 ), but not that of bcl-2 and NF kappa B ...
TNF alpha stimulated
IL-1 beta release from preadipocytes and adipocytes up to 20-fold, but the effect was abrogated by Dex ... In obesity, glucocorticoids may reduce TNF alpha actions in adipose tissue by inhibiting
TNF alpha induced apoptosis,
IL-1 beta release, and TNF alpha expression
Jones et al., J Leukoc Biol 2001
(MAP Kinase Signaling System) :
Unexpectedly, these TLR agonists
induced tumor necrosis factor alpha secretion, whereas only LPS was capable of inducing
interleukin-1beta and nitric oxide secretion
Mendoza et al., Hepatology 2001
(Liver Neoplasms...) :
HSE cells treated with B16M-CM released interleukin (IL)-18 via
tumor necrosis factor-alpha (TNF-alpha) dependent
IL-1beta in vitro ... Thus, liver infiltrating B16M cells activated their adhesion to HSE through a sequential process involving
TNF-alpha dependent
IL-1beta , which induced IL-18 to up-regulate VCAM-1 via H ( 2 ) O ( 2 )
Damås et al., Basic Res Cardiol 2001
:
( ii ) In contrast,
TNFalpha had no effect on IL-10 and only a modest effect on
IL-1beta and IL-6 levels in these cells
Katz et al., Arthritis Rheum 2001
(Inflammation) :
IL-17 ( 10 ng/ml ) stimulated the expression of IL-6 mRNA by 1.3-fold, while
TNFalpha ( 1 ng/ml ) increased it by 3.7-fold, and
IL-1beta ( 0.1 ng/ml )
increased it by > 30-fold
Ferlito et al., J Leukoc Biol 2001
(Leukemia, Monocytic, Acute...) :
However, neither TNF-alpha nor
IL-1beta induced IRAK degradation or
stimulated TNF-alpha or TxB2 production in naive cells
Hakonarson et al., Am J Respir Cell Mol Biol 2001
(Asthma) :
These pro-asthmatic- like changes in ASM responsiveness were associated with
IL-1beta/ TNF-alpha induced mRNA expression of a host of proinflammatory genes that regulate transcription, cytokines and chemokines, cellular adhesion molecules, and various signal transduction molecules that regulate ASM responsiveness
Niemann-Jönsson et al., Arterioscler Thromb Vasc Biol 2001
:
We report here that SMCs isolated from the neointima of injured rat aortas are characterized by increased expression of
TNF-alpha in
response to
interleukin-1beta and gamma-interferon compared with medial SMCs. Basal and serum stimulated DNA synthesis was higher in intimal than in medial SMCs
Griesinger et al., J Soc Gynecol Investig 2001
(Bacterial Infections...) :
The pathogenic microorganisms
induced a dose- and time dependent release of
IL-1beta , IL-6, IL-8, and IL-10, whereas
TNF-alpha secretion was not elevated
Shimada et al., J Immunol 2002
:
Furthermore, IL-17, IL-1beta, and
TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors ( SB203580, PD98059, and U0216 ) significantly
reduced IL-17-,
IL-1beta- , or TNF-alpha induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6
Gould et al., Kidney Int 2002
:
BMP-7 represses the basal and
TNF-alpha stimulated expression of the pro-inflammatory cytokines IL-6 and
IL-1beta , the chemokines MCP-1 and IL-8, and the vasoconstrictor ET-2 in PTEC
Cho et al., Arthritis Rheum 2002
(Arthritis, Rheumatoid) :
In a semiquantitative PCR, CSA increased IL-10 mRNA expression but strongly suppressed
IL-1beta induced IL-15 and
TNFalpha mRNA expression, indicating that the production of these cytokines by CSA was regulated at the transcriptional level
Taranta et al., Bone 2002
:
Furthermore, both compounds were able to inhibit
tumor necrosis factor (TNF)-alpha induced
IL-1beta , but not IL-6, increase
Kim et al., Neurosci Lett 2002
(Alzheimer Disease...) :
The production of
TNF-alpha and IL-6 was
induced by
IL-1beta and Abeta [ 25-35 ] and synergistically amplified by the co-stimulation of IL-1beta and Abeta [ 25-35 ]
Vuolteenaho et al., Osteoarthritis Cartilage 2002
(Osteoarthritis, Knee) :
TNFalpha-antagonists infliximab and etanercept inhibited TNFalpha induced NO production in a dose dependent manner but they
had no effect on
IL-1beta- , IL-17- and LPS stimulated NO synthesis
Cunningham et al., Neuropathol Appl Neurobiol 2002
(Prion Diseases) :
The aim of this study was to determine whether, in the absence of
IL-1beta and IL-6,
tumour necrosis factor (TNF)-alpha may
play an equivalent pro-inflammatory role, or if an anti-inflammatory cytokine profile dominates
Sass et al., Inflamm Res 2002
(Drug-Induced Liver Injury) :
TNF-pretreatment did not affect TNFR-1 expression in the liver and
resulted in time dependent up-regulation of iNOS,
IL-1beta and HO-1 ...
IL-1beta , iNOS and HO-1 neither
mediated TNF-tolerance nor TNF cytotoxicity
Yang et al., Shock 2002
(Endotoxemia...) :
Globin specifically inhibited LPS activity in the standard Limulus assay but did not inhibit
interleukin-1beta mediated
TNF synthesis ... Iron supplementation of macrophage cultures significantly increased
interleukin-1beta induced
TNF release
Havard et al., Virology 2002
:
We evaluated the constitutive and
IL-1beta induced expression of GM-CSF and
TNF-alpha and the expression/activity of NF-kappaB in HPV+ and HPV- cell lines
Taneike et al., FEBS Lett 2002
(Hemolysis) :
Here we demonstrated that E. coli carrying the cloned enterohemolysin operon ( hlyC, A, B, D genes ) from an STEC human strain
induced the production of
interleukin-1beta (IL-1beta) through its mRNA expression but not
tumor necrosis factor-alpha from human monocytes
Turner et al., Placenta 2002
:
The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and
TNFalpha stimulated secretion of
IL-1beta and also reduced IL-6 secretion with the exception of SN50
Yike et al., Mycopathologia 2002
(Apnea...) :
Proinflammatory mediator
IL-1beta increased more than 6-fold and
TNF-alpha 30-fold ( p = 0.001 )
Song et al., Int Immunopharmacol 2002
:
Murine peritoneal macrophages ( PM ) on in vitro treatment with ginsan isolated from Panax ginseng induced mRNA of cytokines such as tumor necrosis factor (TNF)-alpha, interleukin-1 (IL-1)beta, interleukin-6 (IL-6) and interleukin-12 (IL-12) ;
TNF-alpha mRNA induction was maximum within 3 h, IL-6 mRNA was gradually induced up to 24 h, and
IL-1beta and IL-12 mRNA were highly
induced at 24 h. IL-1beta and IL-6 protein levels also increased within 24 h in a dose dependent manner and reached a maximum with 100 microg/ml ginsan
Andersson et al., J Lab Clin Med 2002
:
Captopril impaired production of
tumor necrosis factor-alpha induced
interleukin-1beta in human monocytes is associated with altered intracellular distribution of nuclear factor-kappaB ... Thus captopril reduced
TNF-alpha induced
IL-1beta and IL-1betamRNA synthesis in monocytes, in vitro, probably through interference with NF-kappaB activation of the IL-1beta gene
Honorati et al., Osteoarthritis Cartilage 2002
(Osteoarthritis) :
IL-17 and
TNF-alpha stimulated
IL-1beta release in few subjects
Fujiwara et al., Lab Invest 2002
(Arthritis, Experimental) :
GROalpha does not seem to initiate
TNFalpha , IL-1beta, and IL-8 in an early phase, but
induces IL-1beta and IL-8 in a late phase
Blond et al., Brain Res 2002
(Encephalitis) :
We found that
IL-1beta induces de novo synthesis of additional IL-1beta but not
TNFalpha , as determined by RT-PCR and ELISA, and TNFalpha does not induce either itself or IL-1beta
Lisby et al., Exp Dermatol 2002
:
The signalling mechanisms involved in both
IL-1beta- and TNF-alpha mediated
regulation of
TNF-alpha are critically dependent upon protein kinase C ( PKC ), as demonstrated by blocking studies using protein kinase inhibitors
Lin et al., Crit Care Med 2003
(Hyperoxia) :
Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia
+ tumor necrosis factor-alpha induced leukocyte recruitment and subsequently tumor necrosis factor-alpha,
interleukin-1 beta , and GRO/CINC-1 release
Fan et al., Zhonghua Gan Zang Bing Za Zhi 2003
(Disease Models, Animal...) :
The levels of endotoxin in aorta blood of NASH rats increased significantly at the 24th week ( 0.23 EU/L 0.06 EU/L vs 0.15 EU/L 0.03 EU/L, t > 2.179, p < 0.05 ) while the expression of CD(14) increased from the 4th week, and the Kupffer cells expressing lysozyme were activated, then kept increasing activation through the study. In NASH rats, the levels of serum
TNF-a increased from the 8th week ( 26.39 pg/ml 24.21 pg/ml vs 9.82 pg/ml 9.29 pg/ml, t > 2.145, p < 0.05 ) and serum
IL-1beta increased from the 16th week ( 23.76 pg/ml 21.81 pg/ml vs 6.25 pg/ml 2.98 pg/ml, t > 2.145, p < 0.05 )
Cumberbatch et al., Clin Exp Immunol 2003
:
IL-1beta induced Langerhans ' cell migration and
TNF-alpha production in human skin : regulation by lactoferrin
Didier et al., J Neurochem 2003
:
Concomitantly,
TNF-alpha induced
IL-1beta mRNA expression by astrocytes in co-culture and this effect was partially prevented by ET-1 antibody neutralization
Zhang et al., J Am Dent Assoc 2003
(Chronic Disease...) :
The results showed that lipopolysaccharide and tumor necrosis factor alpha, or
TNF-alpha ,
induced COX-2 in macrophages, while
IL-1beta and TNF-alpha induced COX-2 in oral epithelial cells
Simbirtsev et al., Eur Cytokine Netw 1992
:
Recombinant
IL-1 beta induced a very low level of
TNF alpha production in PMA treated cells ... Similarly recombinant
TNF alpha alone
induced IL-1 beta synthesis only in a few U-937 cells
Patten et al., Naunyn Schmiedebergs Arch Pharmacol 2003
:
Interleukin-1beta mediates endotoxin- and
tumor necrosis factor alpha induced RGS16 protein expression in cultured cardiac myocytes
Chung et al., J Immunol 1992
(Second Messenger Systems) :
Primary rat astrocytes express
TNF-alpha protein in
response to various stimuli including a combined treatment with IFN-gamma and LPS, or IFN-gamma and
IL-1 beta ... This study was undertaken to further elucidate the mechanisms underlying TNF-alpha gene expression in the astrocyte, and to determine the intracellular signaling pathways involved in IFN-gamma/LPS and/or
IFN-gamma/IL-1 beta induction of the
TNF-alpha gene ... Two protein kinase C ( PKC ) inhibitors, H7 and staurosporine, abrogate IFN-gamma/LPS- and
IFN-gamma/IL-1 beta induced
TNF-alpha expression in a dose dependent manner
Ebisawa et al., J Immunol 1992
:
IL-1 beta and TNF-alpha treatment of HuVEC ( 4 h, 5 ng/ml )
induced significant transendothelial migration of eosinophils ( a 4.1 +/- 0.4-fold ( IL-1 beta ) and 2.0 +/- 0.9-fold (
TNF-alpha ) increase from the spontaneous value of 3.2 +/- 0.3 % )
Manni et al., Clin Exp Rheumatol 2003
(Inflammation...) :
NGF down-regulates
IL-1 beta induced
TNF-alpha and iNOS production by OA synovial fibroblasts
Marquette et al., Int J Radiat Biol 2003
(Encephalitis) :
Six hours after irradiation,
IL-1beta levels had increased in the hypothalamus, thalamus and hippocampus, and
TNFalpha and IL-6 levels had
increased significantly in the hypothalamus
Cowland et al., J Immunol 2003
:
IL-1beta induces a > 10-fold up-regulation of NGAL expression in the type II pneumocyte derived cell line A549 cells, whereas
TNF-alpha , IL-6, and LPS had no effect
Hausman et al., Am J Obstet Gynecol 2003
:
Uterine and cervical
interleukin-1beta and interleukin-6 were decreased, and uterine
tumor necrosis factor-alpha increased in celecoxib-B
Duan et al., Clin Cancer Res 2004
(Glioma) :
However, in the resistant cells, the production of
IL-1beta and IL-6 were specifically
impaired in response to
TNF-alpha
Seitz et al., J Clin Immunol 2003
(MAP Kinase Signaling System) :
These data demonstrate that CQ
inhibits IL-1 beta release from monocytes by interfering with pretranscriptional signaling and
TNF-alpha release by posttranslational events whereas GST downregulates IL-1 beta secretion by interfering with posttranslational IL-1 beta processing
Maret et al., Cytokine 2004
:
We compared the production of IL-1alpha,
IL-1beta , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in
response to IL-1alpha,
TNF-alpha , or direct T cell membrane contact
Ledesma et al., Cytokine 2004
:
Interleukin-1 beta (IL-1beta) induces
tumor necrosis factor alpha (TNF-alpha) expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation
Barsness et al., Pediatr Surg Int 2004
(Respiratory Distress Syndrome, Adult) :
There was no IL-10 production in
IL-1beta stimulated adult PMs. IL-1beta induced
TNF production was greater in children compared with adults ( 2152+/-166 vs. 592+/-188, P < 0.05 ) ... In conclusion,
IL-1beta induced IL-6 and
TNFalpha production were greater in pediatric than adult PMs
Soboslay et al., Clin Exp Immunol 1992
(Dermatitis...) :
Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta,
tumour necrosis factor-alpha (TNF-alpha) and IL-6 in
response to mitogenic stimulation with phytohaemagglutinin ( PHA ), only low levels of
IL-1 beta , IL-2 and TNF-alpha in response to OvAg, but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals
Onai et al., Cardiovasc Res 2004
(Myocardial Reperfusion Injury) :
TNF-alpha induced production of
interleukin-1beta and monocyte chemoattractant protein-1 from cultured cardiomyocytes was reduced significantly by IMD-0354
Li et al., Hum Mol Genet 2004
(Crohn Disease) :
In wild-type healthy control, CD and ulcerative colitis individuals, low-dose MDP and
TNFalpha alone
results in only modest
IL-1beta protein induction
Zaga et al., Biol Reprod 2004
(Streptococcal Infections) :
The
TNFalpha was secreted by amnion and choriodecidua in the presence of LPS or GBS, and stimulation with GBS
induced a greater synthesis of
IL-1beta than did stimulation with LPS
Burger et al., J Immunol 2004
:
The production of TNF and
IL-1beta was
induced by membranes of stimulated T cells in the three types of target cells, whereas CD40LT induced
TNF production in IFN-gamma-macrophages only
Tanihara et al., Biochem Biophys Res Commun 1992
:
However, PCR by using cDNA prepared from interleukin-1 beta (IL-1 beta) stimulated RPE cells revealed expression of the gene, suggesting in vivo production of
TNF-alpha from RPE cells in
response to
IL-1 beta
Yang et al., Eur Respir J 2004
(Asthma) :
In order to better understand the control of IL-1beta activity in the airway mucosa, the
role ( s ) of
tumour necrosis factor (TNF)-alpha , cyclic adenosine monophosphate ( cAMP ) and cyclic guanosine monophosphate ( cGMP ) in the release of
IL-1beta and its inhibitors by cultured HAECs were examined ... cAMP increased constitutive and
TNF-alpha stimulated
IL-1beta release but reduced that of sIL-1RII
Lang et al., Clin Nutr 2004
:
The spontaneous and
TNF-alpha stimulated secretion of
IL-1beta , IL-8, IP-10 and MIG from HT-29 and Caco-2 cells was tested with, or without pretreatment with allicin
Moodie et al., FASEB J 2004
:
However, H2O2,
tumor necrosis factor-alpha (TNF-alpha), and
IL-1beta significantly
increased NF-kappaB activation and expression of IL-8 compared with control cells
Panopoulos et al., J Biol Chem 2005
(Inflammation) :
Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of
tumor necrosis factor alpha induced but not
interleukin-1beta induced IkappaB kinase complex/nuclear factor-kappaB activation
Shinozawa et al., Nihon rinsho. Japanese journal of clinical medicine 2004
(Disseminated Intravascular Coagulation...) :
TNF augments inflammation, TNF and IFN-gamma induce coagulation, and
IL-1beta induces coagulation and fibrinolysis
Ahn et al., J Neurotrauma 2004
(Brain Injuries) :
IL-1alpha and
IL-1beta mRNA expression increased significantly ( p < 0.05 vs. sham-injury ) after severe TBI and IL-6 and
TNFa mRNA expression
increased significant ( p < 0.05 vs. sham-injury ) after both moderate and severe TBI
Pedersen et al., Scand J Immunol 2005
(Breast Neoplasms) :
The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha +
IL-1beta + IL-6 + prostaglandin E2 but was not
induced by Poly I:C +
TNF-alpha
Klegeris et al., Neurobiol Aging 2005
(Neuroblastoma) :
Such toxicity was induced by the following combinations : interferon-gamma (IFN-gamma) with tumor necrosis factor-alpha (TNF-alpha) ; IFN-gamma with interleukin (IL) 1alpha or
IL-1beta in the
presence of
TNF-alpha ; and IL-6 with TNF-alpha
Wang et al., Acta Pharmacol Sin 2005
(Hepatitis, Animal) :
Furthermore, MT-Se significantly lowered an increase in
TNF-alpha and IL-1beta levels in the liver and
inhibited the production of TNF- alpha and
IL-1beta by peritoneal macrophages
Sopasakis et al., Int J Obes Relat Metab Disord 2005
:
TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8,
IL-1beta and PAI-1, but not leptin
Baudouin-Legros et al., Am J Physiol Cell Physiol 2005
:
TNF-alpha decreases CFTR mRNA in human colon cell lines ( HT-29 ), but not in pulmonary cell lines ( Calu-3 ), and
IL-1beta increases it only in Calu-3 cells
Wu et al., Kidney Int 2005
:
In the present studies, we examine whether LXA ( 4 ) have inhibitory effects on
tumor necrosis factor-alpha (TNF-alpha) induced productions of
IL-1beta and IL-6 and proliferation of glomerular mesangial cells of rat, and explore the molecular mechanisms of signal pathway of LXA ( 4 ) ... LXA ( 4 ) also antagonized
TNF-alpha stimulated
IL-1beta and IL-6 synthesis, and these antagonisms were related to SHP-2 and NF-kappaB pathway dependent signal transduction
Zhang et al., J Leukoc Biol 2005
:
In the present study, incubation of AM with unopsonized Pneumocystis organisms was not associated with release of
interleukin (IL)-1beta , IL-6, or tumor necrosis factor (TNF)-alpha ( important cytokines in the host response to Pneumocystis ) and did not
induce IL-1beta, IL-6, or
TNF-alpha mRNA transcripts
Ou-Yang et al., Yao Xue Xue Bao 2005
(Granuloma...) :
Furthermore, ginkgolide B at concentrations of 1 x 10 ( -5 ) to 1 x 10 ( -7 ) mol x L ( -1 ) was shown to significantly
inhibit TNF-alpha mRNA expression of U937 cells ; and at concentrations of 1 x 10 ( -5 ) and 1 x 10 ( -6 ) mol x L ( -1 ) could inhibit
IL-1beta mRNA expression ... Ginkgolide B was shown to significantly inhibit angiogenesis of the murine chronic granulomatous air pouch model, reduce the
IL-1beta and TNF-alpha levels in mice serums, and significantly
inhibit IL-1beta and
TNF-alpha mRNA expression and protein secretion in supernatants of U937 cell culture
Rao et al., Mol Cell Biol 2005
(Inflammation) :
Overexpression of IRAK1c suppressed NF-kappaB activation and blocked
IL-1beta induced IL-6 as well as lipopolysaccharide- and CpG induced
tumor necrosis factor alpha production in multiple cellular systems
Fernandes et al., Br J Pharmacol 2005
(Edema) :
TNF-alpha was
necessary for the local PAF induced
IL-1beta production
Prgomet et al., J Vet Med A Physiol Pathol Clin Med 2005
(Mastitis, Bovine) :
Cytokine
[tumour necrosis factor alpha (TNFalpha) ,
IL-1beta , IL-6 ] mRNA expression
responses and transcriptional activity of CD14 and lactoferrin (LF) were quantified via a one-step real-time RT-PCR
Määttä et al., Toxicology 2006
:
All the tested hardwood and softwood dusts induced
TNF-alpha expression and
inhibited IL-1beta expression
Serlin et al., J Cell Biochem 2006
:
Our results demonstrate a potent and dramatic increase in osteopontin expression
induced by interleukin-1beta
(IL-1beta) , whereas
tumor necrosis factor-alpha , transforming growth factor-beta, and angiotensin II had minimal effect
Jensen et al., J Endocrinol 2005
:
Gel retardation experiments showed that hGH affects neither
IFN-gamma+TNF-alpha induced STAT1 DNA binding nor
IL-1beta and IFN-gamma+TNF-alpha induced NFkappaB DNA binding
Klatt et al., Biomed Pharmacother 2006
(Osteoarthritis) :
TAK1 downregulation reduces
IL-1beta induced expression of MMP13, MMP1 and
TNF-alpha
Mpiga et al., Scand J Immunol 2006
(Chlamydia Infections) :
When infected HeLa cells were co-cultured with THP-1 cells, IL-6 and IL-8 secretion was sustained,
IL-1beta expression followed a bell shaped curve and IL-10, IL-12p70 and
TNF-alpha synthesis was down
regulated
Pei et al., Osteoarthritis Cartilage 2006
(Chondrosarcoma) :
IL-1beta and TNFalpha strongly
induced the expression of MMP-1 and -13 in SW1353 cells and HACs, whereas only
TNFalpha was found to induce the expression of these two MMPs in JJ012 cells
Sun et al., World J Gastroenterol 2006
:
VacA alone
induced expression of
TNF-alpha , IL-8 and IL-1beta, while NaCl alone induced expression of TNF-alpha and
IL-1beta
Aida et al., Life Sci 2006
(Inflammation) :
In the present study, we examined the
effect of
IL-1beta on the expression of IL-1beta, IL-6, IL-8, IL-11,
tumor necrosis factor-alpha (TNF-alpha), and their receptors in human chondrocytes ... The expression of IL-1beta, IL-8, and
TNF-alpha markedly increased in the
presence of
IL-1beta after day 14 of culture
Mauviel et al., J Cell Biochem 1991
:
Induction of
interleukin-1 beta production in human dermal fibroblasts by interleukin-1 alpha and
tumor necrosis factor-alpha
Wei et al., Biochimie 2006
:
Promutoxin is also able to stimulate the release of IL-12, TNFalpha, IL-6 and
IL-1beta from human monocytes, and
induce IL-2,
TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning
Bauer et al., J Cell Biochem 2007
(Carcinoma, Hepatocellular...) :
In hepatocytes or human hepatoma cells
TNFalpha is expressed at extremely low levels but TNFalpha biosynthesis can be
induced by interleukin
(IL)-1beta or 12-O-tetradecanoylphorbol-13-acetate ( TPA ) ... Here, we show that
IL-1beta and TPA
stimulated TNFalpha gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element ... Both
IL-1beta and TPA
triggered phosphorylation and activation of the basic region leucine zipper transcription factors c-Jun and ATF2 and expression of dominant negative mutants of c-Jun and ATF2 reduced TNFalpha promoter activity and secretion of
TNFalpha
Slack et al., Blood 1990
(Cell Transformation, Viral) :
Nuclear run-on analyses showed that IL-1 alpha transcriptionally activated the genes for IL-6, GM-CSF, and IL-1 beta, while
TNF alpha transcriptionally
induced expression of IL-6 and
IL-1 beta
Mølvig et al., Scand J Immunol 1990
(Diabetes Mellitus, Type 1) :
We report that
IL-1 beta and
TNF-alpha responses of Mo from TNF-beta 10.5 kb homozygous healthy individuals were significantly higher than for TNF-beta 5.5/10.5 kb heterozygotes ...
IL-1 beta and
TNF-alpha responses of Mo from males ( 18-35 years ) with newly diagnosed ( n = 10 ) and long standing IDDM ( n = 10 ) and from age- and HLA-DR matched healthy males ( n = 10 ) were studied
Zarantonelli et al., Infect Immun 2006
(Meningococcal Infections...) :
Although
tumor necrosis factor alpha production was reduced in mice infected with the mutant of devoid LOS, both LOS mutants
induced production of other proinflammatory cytokines, such as
interleukin-1beta (IL-1beta) , IL-6, and the murine IL-8 homolog KC. Together, these results suggest that meningococcal LOS plays a role during the early infectious and invasive process, and they further confirm that other, nonlipopolysaccharide components of Neisseria meningitidis may significantly contribute to the inflammatory reaction of the host
Churchill et al., Brain Res 2006
:
Relative to saline administration,
IL1beta increased IL1beta,
TNFalpha and IL6 mRNAs in the nucleus tractus solitarius (NTS), hypothalamus, hippocampus and somatosensory cortex ( SSctx ), but did not induce any changes in IL10 ...
TNFalpha also
increased TNFalpha and
IL1beta mRNAs in the hypothalamus, hippocampus and SSctx. TNFalpha increased TNFalpha, IL1beta and IL10 mRNAs in the NTS, but did not induce any changes in IL-6 mRNA ... In the amygdala,
IL1beta enhanced IL6 mRNA and
TNFalpha increased IL1beta mRNAs ... In the insular cortex,
IL1beta enhanced IL6 mRNA and
TNFalpha increased IL1beta mRNA
Deschner et al., J Biomech 2007
(Inflammation) :
Application of CTS for only 1 or 2h during a 24h incubation with IL-1beta was sufficient to inhibit
IL-1beta induced upregulation of
TNF-alpha , TNFR2, and iNOS
Xu et al., Arthritis Rheum 2006
(Arthritis, Rheumatoid) :
SMV prevented the increase in NF-kappaB activation and rise in
IL-1beta and IL-6 levels
induced by
TNFalpha , whereas mevalonate and geranylgeranyl pyrophosphate reversed the inhibitory effects of SMV on activation of NF-kappaB and RhoA
Morello et al., J Immunol 2006
:
IL-1beta and
TNF-alpha rapidly activated p50 and p65, but not C-Rel, RelB, or p52, and both
IL-1beta- and TNF-alpha stimulated A2AR expression was
inhibited by the IkappaB kinase 2 inhibitor AS602868 in a concentration dependent manner
Bondeson et al., Arthritis Res Ther 2006
(Inflammation...) :
Another interesting observation was that in these osteoarthritis cultures of synovial cells,
IL-1beta production was
independent of
TNF-alpha , in contrast to the situation in rheumatoid arthritis
Qin et al., Glia 2007
(Disease Models, Animal...) :
Systemic
TNFalpha and LPS administration activated microglia and
increased expression of brain pro-inflammatory factors ( i.e., TNFalpha, MCP-1,
IL-1beta , and NF-kappaB p65 ) in wild-type mice, but not in TNF R1/R2 ( -/- ) mice
Zhang et al., Am J Respir Cell Mol Biol 2007
(Asthma...) :
Remicade, an anti-TNF-alpha antibody, markedly suppressed IL-1beta induced up-regulation of bradykinin B ( 1 ) and B ( 2 ) receptors, suggesting that TNF-alpha was involved in the up-regulation, which is further supported by the fact that
IL-1beta enhanced
TNF-alpha mRNA expression in the tracheae
Cho et al., Int J Mol Med 2007
:
However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of
TNF-alpha induced
IL-1beta , IL-6, IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells ... We found that curcumin inhibited the expression of
TNF-alpha induced
IL-1beta , IL-6, and TNF-alpha, but not IL-8, in TNF-alpha treated HaCaT cells as well as the TNF-alpha induced cyclin E expression
Yin et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007
:
The combination of TBP and TRBP was able to obviously inhibit both respiratory burst of monocytes induced by TNF-alpha and IFN-gamma and transcription level of
IL-1beta and IL-8 mRNA
induced by
TNF-alpha
Xu et al., Rheumatology (Oxford) 2007
(Arthritis, Rheumatoid) :
The production of
IL-1beta , IL-6 and IL-8
induced by
TNF-alpha was decreased by pyrrolidine dithiocarbamate ( PDTC ), a chemical inhibitor of NF-kappaB ...
TNF-alpha induced production of
IL-1beta , IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha
Rosengren et al., J Allergy Clin Immunol 2007
(Autoimmune Diseases...) :
FCAS monocytes respond to mild hypothermia with
IL-1beta release, which in turn
induces autocrine transcription and secretion of IL-6 and
TNF-alpha as well as stimulation of further IL-1beta production
Bethea et al., J Neuroimmunol 1992
(Astrocytoma) :
Interleukin-1 beta induction of
tumor necrosis factor-alpha gene expression in human astroglioma cells ... In this study, we examined the
effect of human recombinant
interleukin-1 beta (IL-1 beta) on the expression of
TNF-alpha by CH235-MG human malignant glioma cells ... Nuclear run-off analysis demonstrates that
IL-1 beta causes transcriptional activation of the
TNF-alpha gene, and CHX enhances IL-1 beta induced TNF-alpha transcription ... These results indicate that
IL-1 beta , a cytokine present in the central nervous system during some pathological disease states, is a potent
inducer of
TNF-alpha in human malignant glioma cells
Yang et al., Vet Immunol Immunopathol 2007
:
Human
TNF-alpha induced the expression of IP-10 mRNA in porcine endothelial cells, while both human IFN-gamma and human
IL-1beta failed
Nita et al., Int J Biochem Cell Biol 2007
:
In contrast, longer term incubation ( 18 h ) of monocytes with combined AAT/LPS results in a significant reduction in expression of both CD14 and TLR4,
inhibition of LPS induced
TNFalpha ,
IL-1 beta and IL-8 mRNA and protein expression
Fan et al., Immunology 2007
:
LPS induced production of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-10 and interferon-gamma-inducible protein-10 (IP-10); SA induced
TNF-alpha , and IL-1beta production ; and GBS
induced TNF-alpha, IL-6,
IL-1beta , macrophage inflammatory protein-1alpha ( MIP-1alpha ) and keratinocyte chemoattract ( KC ) production were all decreased ( P < 0.05 ) in Galpha ( i2 ) ( -/- ) or Galpha ( i1/3 ) ( -/- ) mice compared with WT mice
Ntrivalas et al., Hum Immunol 2007
:
When PBMC were cultured with a2NTD, there was a 2.5-fold increase in IL1A and
IL1B gene expression and no
induction of
TNF gene expression
Huber et al., Mol Hum Reprod 2007
(Endometriosis) :
Accordingly, hCG-A diminished
IL-1beta induced
TNF-alpha transcript levels and protein release measured by quantitative real-time PCR and enzyme linked immunosorbent assay ... The hormone also attenuated
TNF-alpha dependent mRNA expression of
IL-1beta
Powell et al., J Am Soc Nephrol 1991
(Fever...) :
We conclude that : ( 1 ) plasma
IL-1 beta and TNF-alpha are not chronically elevated in chronic renal failure, continuous ambulatory peritoneal dialysis, or HD patients ; ( 2 ) HD with new Cuprophan or cellulose triacetate membranes and high concentrations of dialysate endotoxin and bacteria does not cause elevation of circulating IL-1 beta or TNF-alpha ; and ( 3 ) pyrogenic reactions might be
mediated by
TNF-alpha
Turner et al., Cardiovasc Res 2007
(Coronary Disease) :
Mechanism of
TNFalpha induced IL-1alpha,
IL-1beta and IL-6 expression in human cardiac fibroblasts : effects of statins and thiazolidinediones ...
TNFalpha ( 0.1-10 ng/ml )
stimulated IL-6, IL-1alpha and
IL-1beta mRNA expression in cardiac fibroblasts in a concentration dependent manner ... Pharmacological inhibitors and receptor neutralizing antibodies established that both
TNFalpha induced IL-6 and
IL-1beta expression was mediated via the TNFRI receptor and p38 mitogen activated protein kinase ( MAPK ), phosphoinositide 3-kinase (PI3K)/Akt and nuclear factor (NF)-kappaB pathways
Ryang et al., Parasitol Res 2007
(Echinostomiasis) :
The
IL-1beta expressions were inhibited by ketotifen in the two strains, but
TNF-alpha expression was
inhibited in the C3H/HeN mice after ketotifen treatment
Huang et al., Zhen Ci Yan Jiu 2007
(Disease Models, Animal...) :
No IL-1beta and
TNF-alpha were
detected in the synovia in control group, while in the other 3 groups, synovia
IL-1beta and TNF-alpha levels increased significantly
Brown et al., Biochem Biophys Res Commun 2007
(MAP Kinase Signaling System) :
Tumor necrosis factor-alpha (TNFalpha) augmented
IL-1beta stimulated release of MMP-9, but not MMP-2 or -3
Konturek et al., Dig Dis Sci 2008
(Adenocarcinoma...) :
Ghrelin caused a decrease in
TNFalpha induced COX-2 and
IL-1beta expression in OE-19 cells
Hall et al., J Biol Chem 2007
(Arthritis, Rheumatoid...) :
These inhibitors selectively target Tpl2 in these cells, and they block LPS- and
IL-1beta induced
TNFalpha production in both primary human monocytes and human blood
Ando et al., BMC physiology 2007
:
Time and dose dependent expression of MAdCAM-1 in
response to
TNF-alpha ,
IL-1 beta and IFN-gamma was studied by immunoblotting
Fang et al., Zhen Ci Yan Jiu 2007
(Inflammation) :
Compared with model group,
IL-1beta mRNA expression of the local inflammatory tissues in IND and EA-post-treatment groups was down-regulated, and
TNF-alpha mRNA expression in Rofecoxib and two EA groups
down-regulated slightly ... Compared with control group, PGE2,
IL-1beta and TNF-alpha contents in the toe tissue of model group increased significantly ; while in comparison with model group, PGE2 and IL-1beta levels in EA-post-treatment group, IL-1beta level in IND group decreased significantly ( P < 0.05 ), and
TNF-alpha level in IND group
increased significantly. No significant differences were found between model group and Rofecoxib and EA-pre-treatment groups in most time-courses of the hind-paw-volume, between model and IND, Rofecoxib and EA-pre-treatment groups in PGE2, between model and EA-pre-treatment groups in IL-1beta, and between model and Rofecoxib, EA-pre-treatment and EA-post-treatment groups in TNF-alpha contents ( P > 0.05 )
Han et al., J Agric Food Chem 2007
:
Compounds 1 and 2 inhibited
tumor necrosis factor (TNF)-alpha induced up-regulation of vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ), which also prevented adhesion of monocytes to HUVECs, and slightly
suppressed the mRNA expression of the inflammation associated gene
interleukin-1beta (IL-1beta)
Oner et al., J Clin Endocrinol Metab 2008
(Chorioamnionitis...) :
Compared with basal outputs by DCs incubated with E2,
TNF-alpha enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold, respectively, and
IL-1beta increased MMP-1 and MMP-3 secretion by 13 +/- 3- and 19 +/- 2-fold, respectively ( P < 0.05 )
Han et al., Int Immunopharmacol 2007
(Dermatitis, Irritant) :
Moreover,
TNF-alpha induced expression of cytokines, such as TNF-alpha and
IL-1beta , and a chemokine, IL-8, were suppressed by silymarin treatment in human keratinocyte cell line, HaCaT
Kjellerup et al., Exp Dermatol 2008
(MAP Kinase Signaling System) :
Furthermore, we show that the Mnk inhibitor CGP57380 is capable of inhibiting the phosphorylation of eIF4E in keratinocytes, and that the abolishment of eIF4E phosphorylation dramatically decreases the anisomycin induced protein release of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), IL-1beta and IL-6 as well as the
IL-1beta induced protein release of
TNF-alpha
Nishida et al., Am J Physiol Gastrointest Liver Physiol 2008
:
Furthermore, LY294002 suppressed both IL-1beta- and
TNF-alpha induced NF-kappaB activation and
IL-1beta- , TNF-alpha-, and IFN-gamma induced activated protein-1 (AP-1) activation
Souza et al., J Endocrinol 2008
:
Caspase-3 activity was
increased by
IL-1beta and the pro-inflammatory cytokine combination, and to a lesser extent by
TNFalpha
Gustavsson et al., Retina 2008
(Diabetes Mellitus, Experimental...) :
Ischemia induced increased expressions of
TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes
induced increased expression of caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ),
IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Kim et al., Phytomedicine 2008
(Arthritis, Experimental) :
As compared with rats treated with saline, BVA i.p. injected at doses of more than 20 microl/100g mouse once a day for 14 days
inhibited the ability of inguinal lymph node cells to produce T cell cytokines
interleukin-1beta , -2, -6,
tumor necrosis factor-alpha and interferon-gamma when the cells were obtained from rats 24 days after immunization and cultured in vitro with CII
Sethu et al., J Immunol 2008
(Calcium Signaling...) :
Furthermore, use of antisense oligonucleotides to reduce expression of PLD1 or PLD2 demonstrated that PLD1 is required for
TNF-alpha induced production of several important cytokines, such as
IL-1beta , IL-5, IL-6, and IL-13, in human monocytes
Kawasaki et al., J Neurosci 2008
(Hyperalgesia...) :
Consistently,
TNFalpha and IL-1beta enhanced AMPA- or NMDA induced currents, and
IL-1beta and IL-6
suppressed GABA- and glycine induced currents
Ikeda et al., Hepatology research : the official journal of the Japan Society of Hepatology 2008
:
In cultured BEC, TNF-alpha, interleukin
(IL)-1beta , IL-6, and interferon-gamma
induced the expression of CDX2 mRNA, though only
TNF-alpha additionally induced the expression of MUC2 mRNA
Cardell et al., Pulm Pharmacol Ther 2008
:
The present study was designed to evaluate the
effects of
IL-1beta on the expression of its corresponding receptor IL-1 RI, as well as on the closely related
TNFalpha receptors TNF RI and TNF RII in airways using a mouse organ culture assay and intranasal inoculation model
Bianchi et al., Neurobiol Aging 2010
(Encephalitis...) :
We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates
IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and
TNF-alpha expression
requires the concurrent activation of NF-kappaB and AP-1
Guillén et al., Rheumatology (Oxford) 2008
(Osteoarthritis) :
In addition, CORM-2 inhibited
IL-1beta induced
TNF-alpha but enhanced IL-1Ra production
Totlandsdal et al., Toxicological sciences : an official journal of the Society of Toxicology 2008
:
In lung cell cultures both particle types
induced release of IL-6 and
IL-1beta , whereas
TNF-alpha was only detected upon exposure to St Louis particles
Enríquez-de-Salamanca et al., Cytokine 2008
(Conjunctivitis, Allergic...) :
After 48 h,
TNF-alpha also
induced a significant increase in
IL-1beta , IL-3, and IP-10 secretion
Hashizume et al., Rheumatology (Oxford) 2008
(Arthritis, Rheumatoid) :
On the other hand,
TNF-alpha and IL-17 did not
induce RANKL expression, although TNF-alpha, IL-17 or
IL-1beta stimulated cell growth and IL-6 production
Kuwano et al., Free Radic Biol Med 2008
:
Interleukin-1beta , flagellin, interferon-gamma, and tumor necrosis factor alpha (TNF-alpha) similarly
induced Nox1 in a colon cancer cell line ( T84 ), whereas only
TNF-alpha fully induced NOXO1 and upregulated superoxide producing activity by ninefold
Jones et al., Osteoarthritis Cartilage 2009
(Osteoarthritis, Knee) :
Over-expression of miR-9, miR-98 or miR-146 in isolated human chondrocytes reduced
interleukin-1 beta (IL-1 beta) induced
TNF-alpha production ... Functional analysis of miR-9, miR-98 and miR-146 in primary chondrocytes suggests a role in mediating the
IL-1 beta induced production of
TNF-alpha
Peltier et al., Am J Reprod Immunol 2008
(Premature Birth) :
P4 enhanced the production of
IL-1beta and IL-8, but
inhibited TNF-alpha production by monocytes stimulated with either organism
Ho et al., Shock 2009
(Acute Disease...) :
Intravenous LPS ( 10-50 mg/kg ) dose-dependently increased plasma endotoxin and reactive oxygen species in the blood, bile, and liver and increased plasma alanine aminotransferase and aspartate aminotransferase levels as well as
TNF-alpha , monocyte chemoattractant protein 1, tissue
inhibitor of metalloproteinase 1,
IL-1beta , and IL-6 levels in the rats
Xing et al., Neuropathology 2009
(AIDS Dementia Complex...) :
IL-1beta was
detected in the frontal white matter of all 11 cases where microglial nodules were observed to varying degrees, whereas
TNF-alpha was detected in seven cases
Song et al., Mol Immunol 2009
(Inflammation) :
Ablation of IRAK-4 expression in human umbilical vein endothelial cells ( HUVEC ) with siRNA suppressed
IL-1beta induced IL-6 and IL-8 production whereas IRAK-1 siRNA suppressed
TNFalpha induced but not IL-1beta induced cytokine production
Marucha et al., J Immunol 1991
:
We have previously demonstrated that Il-1 and
TNF could rapidly, but transiently,
induce gene expression of
Il-1 beta in human polymorphonuclear leukocytes ( PMN ) at both the protein and mRNA level ... Using nuclear run-on transcription analysis, we found that within 1 h Il-1,
TNF , and TNF plus Il-1
induced the transcription of the
Il-1 beta gene by 33-, 61-, and 99-fold, respectively ... This abrogation of Il-1 beta mRNA accumulation was not caused by inhibition of induction of Il-1 beta transcription because
TNF induction of transcription of
Il-1 beta was not affected by simultaneous treatment with cycloheximide ... Thus, we report that Il-1 and
TNF regulate
IL-1 beta gene expression via both transcriptional and post-transcriptional mechanisms in vitro
Millward-Sadler et al., Arthritis Res Ther 2009
(Intervertebral Disc Degeneration) :
Quantitative real-time polymerase chain reaction was used to assess the
effect of
TNF-alpha or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3, -9 and -13, TNF-alpha, TNF receptor 1 (TNF-R1), TNF receptor 2 (TNF-R2), IL-1alpha,
IL-1beta , IL-1 receptor 1 (IL-1R1) and IL-1 receptor antagonist (IL-1Ra)
Snegovskikh et al., Reprod Sci 2009
(Chorioamnionitis...) :
This effect appears to be mediated at the level of gene transcription because stimulation with
IL-1 beta ( but not
TNF-alpha )
increased expression of VEGF mRNA as measured by real-time quantitative reverse transcriptase-polymerase chain reaction ( RT-qPCR ) ; a similar increase was seen in neuropilin-1/-2 ( but not Flt1 and KDR2 ) mRNA
Tanida et al., Cytokine 2009
(Arthritis, Rheumatoid) :
IL-1beta vigorously induced the production of CCL20 from FLSs of human RA and the production of CCL20 induced by TNF-alpha was partially attributed to a trace amount of
IL-1beta induced by
TNF-alpha
Li et al., Neuroscience 2009
(Disease Models, Animal...) :
Interestingly, treatment with EP2 antagonist AH-6809 resulted in suppression of hypoxia
induced EP2,
IL-1beta and iNOS mRNA and protein expression,
TNF-alpha protein expression and intracellular cAMP level in BV-2 cells
Meusch et al., Arthritis Rheum 2009
(Arthritis, Rheumatoid) :
Instead, transmembrane
TNF reverse signaling inhibited the constitutive NF-kappaB activation in RA monocytes,
suppressed IL-1beta secretion, and normalized spontaneous in vitro apoptosis
Ruan et al., Curr Alzheimer Res 2009
(Alzheimer Disease...) :
Expression of
TNF-alpha was
detected at 8 months of age, while
IL-1 beta , IL-6 and MCP-1 at 10 months
Matsui et al., J Ethnopharmacol 2009
:
Aqueous extract of Vitex trifolia leaves showed significant dose- and time dependent inhibitory activity on
interleukin (IL)-1 beta , IL-6 and iNOS mRNA synthesis, but slight
effect on
tumor necrosis factor (TNF)-alpha , all of which are involved in the inflammatory response
Liu et al., Proc Natl Acad Sci U S A 2009
:
Neither JNK1 activation by
IL-1beta or UV nor
TNF-alpha induced
activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1
Huang et al., Head Neck 2010
(Carcinoma...) :
LMP1 mediated IL-1alpha and
IL-1beta production could be
enhanced by
tumor necrosis factor alpha (TNF-alpha) , determined by enzyme linked immunosorbent assay ( ELISA )
Gossye et al., Arthritis Rheum 2009
(Arthritis, Rheumatoid) :
Quantitative polymerase chain reaction was performed to detect the
tumor necrosis factor alpha (TNFalpha) induced cytokine gene expression of
interleukin-1beta (IL-1beta) and to investigate the effects of DEX and CpdA in RA fibroblast-like synoviocytes ( FLS ) transfected with small interfering RNA ( siRNA ) against GR ( siGR ) compared with nontransfected cells
Saperstein et al., Mediators Inflamm 2009
(Acute Disease...) :
We determined the
role of
interleukin-1beta (IL-1beta) signaling on tumor necrosis factor alpha induced ( TNF-alpha ) lung neutrophil influx as well as neutrophil chemoattractant macrophage inflammatory protein ( MIP-2 ) and KC and soluble
TNF-alpha receptor (TNFR) levels utilizing wildtype ( WT ), TNF receptor double knockout ( TNFR1/TNFR2 KO ), and IL-1beta KO mice after oropharyngeal instillation with TNF-alpha
Bai et al., J Immunol 2010
(Tuberculosis) :
Inhibition of endogenous IL-32 production in THP-1 cells that express one of three distinct shRNA-IL-32 constructs significantly decreased M. tuberculosis
induction of
TNF-alpha by approximately 60 %,
IL-1beta by 30-60 %, and IL-8 by 40-50 % and concomitantly increased the number of cell associated M. tuberculosis bacteria compared with THP-1 cells stably expressing a scrambled shRNA
Watanabe et al., J Med Virol 2010
(Respiratory Syncytial Virus Infections) :
On day 1 after infection, the secretion of both
TNF-alpha and IL-6 decreased significantly in the bronchoalveolar lavage fluid prepared from RSV infected offspring exposed to DBDE perinatally, but
IL-1beta increased
Kato et al., Glycoconj J 2010
:
Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody, ERTR9,
induced production of IL-12 and
tumor necrosis factor (TNF)-alpha from PEMs, while secretion of IL-6 and
IL-1beta was not detected with the same treatment
Choi et al., Food Chem Toxicol 2010
(Sarcoma) :
This study was conducted to evaluate the efficacy of luteolin in regulating
interleukin-1beta (IL-1beta) induced production of MMPs ( MMP-1 and -3 ) and cytokines (
tumor necrosis factor (TNF)-alpha and IL-6 ) in human synovial cell line, SW982
Shingu et al., Life Sci 1991
:
Recombinant human IL-1 beta and
TNF-alpha stimulate production of IL-1 alpha and
IL-1 beta by vascular smooth muscle cells and IL-1 alpha by vascular endothelial cells
Lu et al., Journal of neuroinflammation 2010
(Inflammation) :
Resveratrol inhibited LPS induced expression and release of
TNF-alpha , IL-6, MCP-1, and iNOS/NO in both cell types with more potency in microglia, and
inhibited LPS induced expression of
IL-1beta in microglia but not astrocytes
Floege et al., Kidney Int 1990
:
Stimulation with interleukin-1 beta (IL-1 beta) or
tumor necrosis factor alpha (TNF alpha) induced up to 18-fold (
IL-1 beta ) or up to fourfold ( TNF alpha ) increases of prostanoid release
Chung et al., J Immunol 1990
:
IFN-gamma and
IL-1 beta alone do not
induce TNF-alpha production, however, the combined treatment of IFN-gamma and IL-1 beta results in a striking synergistic effect on astrocyte TNF-alpha production
Elias et al., Chest 1990
(Pneumonia...) :
To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the
effects of recombinant interleukin-1,
tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production,
interleukin-1-beta production, and interleukin-6 production
Wetzler et al., Cancer Res 1990
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
However, granulocyte colony stimulating factor expression could be induced by recombinant human
IL-1 beta ; while IL-6 could be
induced by both IL-1 beta and
tumor necrosis factor-alpha
Marucha et al., J Immunol 1990
(Inflammation) :
In the present study, we demonstrate that human peripheral blood PMN produce
IL-1 beta in
response to IL-1 alpha, IL-1 beta, and
TNF-alpha
Long et al., Am J Physiol 1990
(Fever) :
These data support the hypotheses that
IL-1 beta is responsible for a significant part of LPS fever and that
TNF acts as an endogenous antipyretic to limit the magnitude of LPS fever in the rat
Hou et al., Wei Sheng Yan Jiu 2012
:
To investigate the effects of citreoviridin (CIT) on the expression of MCP-1,
IL-1beta , IL-6 and IL-8
induced by
TNF-alpha in human umbilical vein endothelial cells ( HUVECs )
Kumamaru et al., Journal of neuroinflammation 2012
:
Furthermore, we observed rapid
tumor necrosis factor-a and
IL-1b gene
induction in conventional primary astrocyte cultures after IL-6 stimulation, which was due to the activation of the Janus kinase/signal transducer and activator of the transcription pathway in contaminating microglia
Catanzaro et al., J Biol Regul Homeost Agents 2012
:
In the present study, we examined the effect of a marine bioactive compound containing high-purity caviar derived DNA, collagen elastin and protein extracts from sturgeon ( LD-1227, Caviarlieri, Laboratoires Dom, Switzerland ) on
IL-1beta induced activation and production of
TNFalpha and MMP-13 in human osteo-arthritis ( OA ) chondrocytes and intracellular signaling factors ... LD-1227 significantly decreased
IL-1beta stimulated gene expression and production of
TNFalpha , MMP-1, MMP-13 and Col10A1 in human chondrocytes
Swangchan-Uthai et al., Biol Reprod 2012
(Cattle Diseases...) :
A 48 h, LPS time course study showed that
TNF increased first at 1 h, followed by peak expression of
IL1B at 6 h, and those of S100A8, S100A12, and LAP at 12 h
Majewska et al., Med Sci Monit 2012
(Uremia) :
IL-1beta markedly diminished and
TNF-alpha significantly
increased cC concentration in culture supernatants
Smith et al., Cancer Res 1990
:
The
induction of
TNF and interleukin 1 beta (IL-1 beta) mRNA by exogenous TNF or
IL-1 beta , as determined by Northern blot analysis, is time dependent in normal human monocytes isolated by countercurrent elutriation
Suzuki et al., Am J Pathol 1989
:
IL-1,
tumor necrosis factor (TNF) , and LPS not only enhanced the accumulation of c-sis mRNA, but also
induced IL-1 beta gene expression
Chantry et al., J Immunol 1989
:
TGF-beta inhibited in a dose dependent manner the
induction of
IL-1 beta by LPS or
TNF but not by PHA and PMA
Turtinen et al., Microb Pathog 1989
:
In both CMV infected and uninfected cultures, significant amounts of IL-1 beta protein were not detected until 24 h post induction, while maximum amounts of TNF were detected in culture supernatants by 3 h post induction, suggesting that
TNF may
play a role in
IL-1 beta induction
Gitter et al., Immunology 1989
:
Further examination of
IL-1 beta- and
TNF alpha induced PGE2 secretion revealed IL-1 beta to be a more potent stimulator ; however, this observation may be due, in part, to differences in the kinetics of induction
Demetri et al., Blood 1989
(Mesothelioma) :
Interleukin-1 beta (IL-1 beta) transcripts were
induced by EGF,
TNF , or LPS and were inhibited by hydrocortisone ( HC )
Elias et al., Proc Natl Acad Sci U S A 1989
:
In addition, simultaneous stimulation with recombinant IL-1 ( alpha or beta ) and recombinant
TNF resulted in a synergistic increase in
IL-1 beta mRNA levels
Pober et al., Ciba Found Symp 1987
(Inflammation) :
TNF and LT induce reciprocal tachyphylaxis for the reinduction of H4/18 binding but do not inhibit induction by IL-1 alpha and IL-1 beta ; similarly, IL-1 alpha and
IL-1 beta induce reciprocal tachyphylaxis but do not
inhibit TNF or LT
Le et al., J Immunol 1987
:
Induction with TNF resulted in the appearance of IL 1-alpha mRNA and a very significant increase in IL 1-beta mRNA, indicating that
TNF induces the synthesis of both IL 1-alpha and
IL 1-beta in FS-4 cells
Yucel-Lindberg et al., J Periodontal Res 1995
:
Addition of BK, in the
presence of
TNF alpha , for 1 h and 6 h, respectively, synergistically enhanced the TNF alpha induced
IL-1 beta production, whereas BK alone did not induce IL-1 production
Bristulf et al., Neurosci Lett 1995
:
Furthermore,
IL-1 beta also
induced increases in
TNF alpha and c-fos mRNAs
Vecchiarelli et al., Infect Immun 1995
:
The secretory response of these cytokines follows different pathways of macrophage activation ; in fact, complete inhibition of
TNF-alpha does not
affect IL-1 beta production and vice versa
Grooteman et al., ASAIO J 1995
:
Interleukin 1 beta and interleukin 6 could not be
detected at all, whereas
tumor necrosis factor alpha levels were marginally elevated before and after HD with both membranes
Pivirotto et al., Mol Cell Endocrinol 1995
:
Tumor necrosis factor-alpha (TNF) dependent increase
IL-1 beta mRNA levels were additive to the effects of the steroids ... Testosterone and
TNF increased
IL-1 beta protein release ( P < 0.05 ) while 17 beta-estradiol had little effect on release
Seitz et al., Br J Rheumatol 1995
(Arthritis, Rheumatoid) :
In addition, clinical improvement was associated with decreased synthesis of IL-1 beta,
TNF-alpha and IL-8
induced by bacterial lipopolysaccharide, IL-1 alpha and
IL-1 beta in PBMC in vitro
Delomenie et al., Exp Cell Res 1993
:
Intracellular IL-1 alpha and
IL-1 beta levels were markedly
enhanced by IL-1 beta and
TNF alpha
Granowitz et al., J Immunol 1993
:
This suppression was not specific for endotoxin ;
IL-1 beta induced IL-1 alpha and
TNF-alpha were reduced by 84 % ( p = 0.01 ) and 68 % ( p < 0.001 ), respectively
Reuss-Borst et al., Br J Haematol 1993
(Myelodysplastic Syndromes...) :
During the acute phase of the disease with high remittent fever, painful skin lesions and maximal leucocytosis IL-6 and G-CSF serum levels were extremely high, while
TNF-alpha was only slightly elevated and gamma-interferon and
IL1-beta were not
increased
Yavuzyilmaz et al., Aust Dent J 1995
(Gingival Hemorrhage...) :
While
IL-1 beta was detected in all of the GCF samples studied,
TNF-alpha could only be
detected in about half the samples
Rice et al., Shock 1994
(Inflammation) :
CT-1501R also inhibited IL-1 alpha or
IL-1 beta induction of either TNF-alpha or IL-1 beta and
inhibited the synergistic effects of stimulation with both human IL-1 beta and murine
TNF-alpha on release of human TNF-alpha
Panja et al., Clin Exp Immunol 1995
:
LPS, IFN-gamma or
TNF-alpha had no effect on spontaneous IL-6 production, and neither
resulted in the secretion of
IL-1 beta or TNF-alpha
Judd et al., Am J Physiol 1995
:
ZG cells released IL-6 and
TNF , and this release was
stimulated by lipopolysaccharide, interleukin-1 alpha,
interleukin-1 beta , a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Danis et al., Clin Exp Immunol 1995
:
TNF-alpha also
up-regulated production of IL-1 alpha,
IL-1 beta , IL-1Ra and IL-6 by monocytes, but the variability in the results of cells cultured from the same individuals on different occasions was greater
Walters et al., J Leukoc Biol 1995
:
TNF primes polymorphonuclear leukocytes ( PMNs ) for enhanced oxidative and secretory activity and directly
induces adhesion and
IL-1 beta expression
Arinaga et al., Int J Immunopharmacol 1994
(Digestive System Neoplasms) :
However, the ability of monocytes in PBM to produce
TNF-alpha was significantly
enhanced 5 days after the drug administration, although IL-1-alpha and
IL-1-beta production was not augmented
Aman et al., Blood 1994
:
Production of granulocyte-macrophage colony stimulating factor ( GM-CSF ), granulocyte-CSF (G-CSF), and
interleukin-1 beta (IL-1 beta) in stromal cell layers was
induced by incubation with IL-1 alpha,
tumor necrosis factor (TNF) , or lipopolysaccharide (LPS)
De Bandt et al., Metabolism 1994
:
These results indicate that ( 1 ) in the conditions of the study,
IL-1 beta has no direct effect on hepatic amino acid exchanges and utilization ; ( 2 )
TNF alpha which exerted an inhibitory effect on these parameters, could be
involved in the reduced amino acid exchanges during the end stage of sepsis ; ( 3 ) the TNF alpha induced increase in glucose uptake could be related to an inhibition of gluconeogenesis and/or to the activation of glucose utilization by Kupffer cells ; ( 4 ) IL-1 beta and TNF alpha both potentiate the action of glucagon on hepatic amino acid uptake and utilization ; and ( 5 ) complex interactions between Kupffer cells and hepatocytes on the one hand and between cytokines and hormones on the other hand could account for the differences in hepatic metabolism according to the stage of the response to injury
Hadjiminas et al., Surgery 1994
(Bacteremia...) :
Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced
interleukin-1 beta expression but not
inhibition of
tumor necrosis factor synthesis
Meda et al., Cell Immunol 1994
:
Unlike IL-8, the LPS stimulated production of TNF and IL-1 beta, as well as the
TNF stimulated production of
IL-1 beta , was markedly enhanced by IFN-gamma over the entire incubation period ( up to 18 hr )
Chen et al., Neurosurgery 1993
(Brain Neoplasms...) :
Furthermore, in U-87 cells,
TNF-alpha enhanced both ICAM-1 and
interleukin-1 beta (IL-1 beta) expression, and decreased immunoreactivity for transforming growth factor-beta ( TGF-beta ) protein
Contrino et al., Pediatr Res 1993
:
In our present studies, we found that
tumor necrosis factor-alpha and lipopolysaccharide could
induce IL-1-beta expression in both neonatal and adult PMN and that neonatal PMN produced significantly more IL-1-beta when compared with adult PMN
Molnar-Kimber et al., Agents Actions 1993
:
Zaprinast
stimulated IL-1 beta and to a lesser extent
TNF alpha production
Manthey et al., Infect Immun 1993
:
Herein, we examined the ability of these structures to
regulate murine macrophage
tumor necrosis factor (TNF) secretion and LPS-inducible gene expression ( tumor necrosis factor alpha [TNF-alpha ],
interleukin-1 beta [IL-1 beta ], IP-10, type 2 TNF receptor [TNFR-2 ], D3, and D8 genes )
Hamilton et al., J Leukoc Biol 1993
:
There was a significant increase of
IL-1 beta mRNA levels ( unstimulated cells ) on days 1 and 7, but
TNF-alpha mRNA levels
increased significantly on day 1 only
Hahn et al., J Clin Invest 1993
(Arthritis, Rheumatoid) :
In particular,
IL-1 beta and neopterin production were further
enhanced by stimulation with either interferon-gamma (IFN-gamma) or
TNF-alpha without a synergistic effect
Agarwal et al., J Periodontal Res 1995
:
IL-1 beta activation of GF cells showed that
IL-1 beta non only
induces the expression of IL-6, IL-8 and
TNF-alpha , but also acts in an autocrine manner of GF cells and induces IL-1 beta expression ... Pretreatment of GF cells with IL-1 beta resulted in the enhanced synthesis of
TNF-alpha in
response to additional
IL-1 beta
Downs et al., Int J Immunopharmacol 1995
(Pulmonary Edema) :
Associated with these improvements in organ dysfunction and survival was a modest decrease in LPS stimulated interleukin-1 alpha (IL-1 alpha) and
interleukin-1 beta (IL-1 beta) secretion and a marked ( > 90 % )
inhibition of
TNF secretion by MDL 101,002
Herbert et al., Eur J Pharmacol 1995
(Hyperemia) :
Tumor necrosis factor-alpha prevents
interleukin-1 beta from augmenting capsaicin induced vasodilatation in the rat skin
Wassen et al., Endocrinology 1996
:
We conclude that 1 ) IL-1 beta decreases TSH release by a direct action on the pituitary ; 2 ) this effect is not due to elevated thyroid hormone uptake or increase T3 nuclear occupancy ; 3 )
IL-1 beta does not affect TRH induced TSH release or the release of other anterior pituitary hormones ; and 4 )
TNF alpha affects basal and TRH induced TSH release in the same way as IL-1 beta
Fernandez et al., J Leukoc Biol 1996
:
Thus, GM-CSF increases IL-1 beta message accumulation in PMN at both the transcriptional and post-transcriptional levels by mechanisms that are different from
TNF induction of
IL-1 beta gene expression
Lieb et al., J Neurochem 1996
(Astrocytoma) :
For a better understanding of their pathogenic role, we analyzed signal transduction pathways mediating the interleukin
(IL)-1 beta induced synthesis of IL-6 and
tumor necrosis factor alpha (TNF alpha) in the human astrocytoma cell line U373 MG ... Whereas activation of protein kinase A was able to induce expression of the IL-6 gene, it did not induce TNF alpha gene expression and was not involved in
IL-1 beta induced IL-6 and
TNF alpha gene expression
Brunius et al., Eur J Oral Sci 1996
(Gingival Hyperplasia) :
TNF alpha , in contrast to PHT, dose-dependently
stimulated the production of cell associated
IL-1 beta ... The stimulatory
effect of
TNF alpha on
IL-1 beta production was accompanied by enhanced PGE2 formation ... When PHT and TNF alpha were added simultaneously, the drug potentiated the stimulatory
effect of
TNF alpha on both
IL-1 beta production and PGE2 formation ... The production of
IL-1 beta induced by
TNF alpha and the combination of TNF alpha and PHT was further enhanced in the presence of the prostaglandin endoperoxide ( PGH ) synthase inhibitors, indomethacin and flurbiprofen ... The PHT mediated enhancement of
TNF alpha induced
IL-1 beta production and PGE2 formation in gingival fibroblasts may be an important link in the pathogenesis of gingival overgrowth induced by PHT
Vasilescu et al., Eur Surg Res 1996
:
Our results indicate that the leukocyte derived production of IL-6 and
IL-1 beta in whole blood is stimulated directly by endotoxin and is not
mediated by
TNF alpha
Rambukkana et al., Lab Invest 1996
:
After 24 hours, contact allergens not only increased the expression of
IL-1 beta but also
induced the expression of IL-1 alpha,
TNF-alpha , GM-CSF, and IL-6 proteins mainly by suprabasal keratinocytes
Boehm et al., Exp Dermatol 1996
(Dermatitis, Toxicodendron...) :
The data provide evidence for an in vivo
role for epidermal IL-1 alpha,
IL-1 beta and TNF-alpha transcription in the regulation of IL-1 beta and
TNF-alpha polypeptide levels in the epidermis in response to this common contact allergen
Wong et al., Immunol Cell Biol 1996
:
While beta-casein had no significant effects on IFN gamma production by ovine blood lymphocytes, and
TNF alpha production and MCH Class II antigen expression by ovine bronchoalveolar macrophages, it
enhanced IL-1 beta production by the macrophages, beta-casein also had no influence on bovine NK cell activity against a virally infected cell line
Brooks et al., Clin Exp Immunol 1996
(Arteritis...) :
They have been shown previously to produce the cytokine
IL-1 beta in
response to stimulation with
TNF
Someya et al., Immunopharmacol Immunotoxicol 1996
(Endotoxemia...) :
Meanwhile, DY-9973 did not inhibit
IL-1 beta induced
TNF-alpha production in U937 cells ...
TNF-alpha production
induced by LPS or
IL-1 beta was similarly inhibited by treatment with herbimycin, a tyrosine kinase inhibitor
Ortiz-Arduan et al., Am J Physiol 1996
(Endotoxemia) :
Lipopolysaccharides (LPS),
interleukin-1 beta , interferon-gamma (IFN-gamma), and
TNF-alpha increase the levels of Fas mRNA in cultured mesangial and tubular cells
Hörnquist et al., J Immunol 1997
(Colitis, Ulcerative) :
Thus, IFN-gamma and
IL-1beta levels were
increased 13-fold and 30-fold, respectively, with more modest increases in IL-6 levels ( 5-fold ) and
TNF levels ( 2-fold )
Antras-Ferry et al., FEBS Lett 1997
:
TNF-alpha rapidly
induced Mn-SOD gene expression while
IL-1beta was a strong but slow inducer of this gene
Yamaoka et al., Scand J Gastroenterol 1995
(Gastritis...) :
Although
IL-1 beta and IFN-gamma mRNA were detected in most specimens, IL-2, IL-3, IL-4, IL-5, IL-9,
TNF-alpha , and IFN-beta mRNA were not
detected at all
Knöfler et al., FEBS Lett 1997
(Choriocarcinoma...) :
However, treatment with cycloheximide did not prevent
IL-1beta stimulated release of
TNF-alpha , indicating that the cytokine can regulate TNF-alpha secretion at a posttranslational level, independently of TNF-alpha mRNA induction
Weeks et al., DNA Cell Biol 1997
:
This increase in CDS activity also leads to increased secretion of
tumor necrosis factor-alpha and interleukin-6 from endothelial ECV304 cells upon
stimulation with
interleukin-1beta , suggesting that CDS overexpression may amplify cellular signaling responses from cytokines
Ritchie et al., Cytokine 1997
:
LPS- and
IL-1 beta stimulated adrenal
TNF release was inhibited by adenosine
Matsukawa et al., Lab Invest 1997
(Arthritis, Experimental...) :
Maximum levels of
TNF alpha and IL-8 were
detected at 2 hours after LPS-injection, whereas
IL-1 beta and IL-1 receptor antagonist (IL-1Ra) were detected at 6 and 9 hours, respectively ... These results provide new evidence that IL-8 as well as
TNF alpha are the most proximal cytokines and
induce subsequent production of
IL-1 beta and IL-1Ra
Al-Harthi et al., J Infect Dis 1997
:
The in vitro efficacy of protease inhibitor to block
tumor necrosis factor (TNF)-alpha , interleukin (IL)-6, IL-1alpha, and
IL-1beta induction of HIV-1 was investigated
Lin et al., Mol Cell Endocrinol 1994
:
IL-1beta alone in concentrations of 0.1, 1 and 10 ng/ml inhibited testosterone formation by 45 %, 62 % and 91 %, respectively, in the presence of
TNF-alpha ( 10 ng/ml ), IL-1beta in a concentration as low as 0.1 ng/ml completely
blocked hCG induced testosterone formation
Van der Poll et al., Am J Physiol 1997
:
To determine the effect of epinephrine on IL-1 beta production, the following experiments were performed : 1 ) blood obtained from subjects at 4-21 h after the start of a continuous infusion of epinephrine ( 30 ng.kg-1.min-1 ) produced less IL-1 beta after ex vivo stimulation with lipopolysaccharide (LPS), compared with blood drawn from subjects infused with saline ; 2 ) in whole blood in vitro, epinephrine caused a dose dependent decrease in LPS induced IL-1 beta production, which was likely mediated via adrenergic receptors ; and 3 ) inhibition of
TNF and enhancement of IL-10 both
contributed to epinephrine induced inhibition of
IL-1 beta production
Hirata et al., Am J Respir Cell Mol Biol 1998
(Lung Neoplasms) :
The
TNF-alpha level in the supernatants significantly increased at 120 min after allergen stimulation, and the interleukin
(IL)-1beta level
increased in 4 of 15 samples
Schroeder et al., Hepatology 1998
:
Parallel experiments examining
IL-1beta mediated endogenous hepatocyte IL-1beta and
TNF-alpha synthesis indicated no role for these cytokines in the induction of iNOS expression by IL-1beta
van der Velden et al., Cytokine 1998
(Second Messenger Systems) :
IL-1 beta , and to a lesser extent,
TNF-alpha and IL-4
increased NEP activity and expression, whereas IFN-gamma decreased NEP
Arnush et al., J Immunol 1998
(Diabetes Mellitus, Type 1) :
IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta
prevents TNF + LPS induced nitrite production by rat islets
Jobin et al., J Immunol 1998
:
Induction of inducible nitric-oxide synthase (iNOS),
IL-1beta , and IL-8 genes by IL-1beta,
TNF-alpha , or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA
Mustafa et al., Eur J Oral Sci 1998
:
When gingival fibroblasts were treated simultaneously with triclosan ( 0.25, 0.5 microg/ml ) and TNFalpha ( 10 ng/ml ), the stimulatory
effect of
TNFalpha on
IL-1beta production was reduced by the agent
Matsukawa et al., Lab Invest 1998
(Arthritis) :
These results provide evidence that IL-8 and
TNFalpha were
responsible for the production of
IL-1beta and IL-1Ra, and that IL-1beta was responsible for the second phase of IL-1beta and IL-8 production
Arnush et al., J Clin Invest 1998
:
Reverse transcriptase polymerase chain reaction was used to confirm that
TNF + LPS + IFN-gamma
stimulates the expression of both IL-1alpha and
IL-1beta in human islets
Paulose et al., Microb Pathog 1998
:
Supernatant from TPV infected cells significantly decreased the
TNF-alpha but not
IL-1 beta induced expression of these molecules
Compton et al., J Immunol 1998
:
Reverse-transcription PCR analysis indicated up-regulation of mRNA for IL-8 as well as for
IL-1 beta in
response to tryptase or
TNF-alpha
Koyama et al., Am J Physiol 1998
:
IL-1beta stimulated the release of G-CSF in a dose dependent fashion, but the time dependent profile of G-CSF showed that the concentration of G-CSF declined after 48 h.
Tumor necrosis factor (TNF)-alpha , Escherichia coli lipopolysaccharide (LPS), and bradykinin ( BK ) stimulated A549 cells to release NCA that was inhibited by anti-G-CSF antibody
Plata-Salamán et al., Am J Physiol 1998
(Fever...) :
The results show that 1 ) both IL-1beta and IL-6 induce fevers in obese and lean rats ; 2 )
IL-1beta induces a significantly higher fever response in obese rats than it does in lean rats ; 3 ) IL-6 induces a significantly higher fever response in lean rats than it does in obese rats ; 4 ) IL-2 induces a moderate fever response in lean but not obese rats ; 5 )
TNF-alpha induces a similar fever response in obese and lean rats ; and 6 ) the fevers induced by each effective cytokine have different time courses
Beissert et al., J Invest Dermatol 1998
(Hypersensitivity, Delayed...) :
Therefore, the ability of IL-1alpha or
IL-1beta to
induce epidermal cell production of
TNF alpha was assessed
Manni et al., Rheumatol Int 1998
(Arthritis, Experimental) :
Out data showed that IL-1 beta, but not
TNF-alpha ,
induces an increase in NGF levels, while concomitant injection of both cytokines enhances the effect of
IL-1 beta on NGF presence
Gayle et al., Brain Res Bull 1998
(Brain Neoplasms...) :
The data show that ( 1 )
IL-1beta induced a significant upregulation of TNF-alpha mRNA ; ( 2 ) the effect of IL-1beta on
TNF-alpha mRNA expression was completely
blocked by the concomitant application of IL-1Ra, which suggests specificity of IL-1beta action through the IL-1 signaling receptor ; ( 3 ) no detectable modulation of TNF-alpha mRNA expression was observed with the individual applications of TNF-alpha, IL-6, or IFN-alpha; (4) the concomitant treatments of TNF-alpha + IL-1beta or TNF-alpha + IL-1beta + IL-6 strongly upregulated TNF-alpha mRNA expression, whereas the concomitant application of TNF-alpha + IL-6 or IL-1beta + IL-6 induced a moderate increase ; and ( 5 ) IFN-alpha significantly attenuated induction of TNF-alpha mRNA by TNF-alpha + IL-1beta + IL-6
Wördemann et al., J Interferon Cytokine Res 1998
(Carcinoma, Hepatocellular...) :
We studied effects of diverse drugs on the formation of immunoreactive TNF-alpha in the human hepatoma cell lines HepG2 and Hep3B, in which
TNF-alpha production was
induced by treatment ( 3 h incubation periods ) with
interleukin-1beta ( IL-1beta, 300 pg/ml ) or phorbol myristate acetate ( PMA, 100 nmol/l ) ... Pentoxifylline ( 1 mg/ml ) did not influence PMA induced TNF-alpha production, but it augmented
IL-1beta induced
TNF-alpha production
Cumberbatch et al., Arch Dermatol Res 1998
:
The hypothesis is that
IL-1beta induces the production by keratinocytes of
tumour necrosis factor alpha (TNF-alpha) which acts in a paracrine fashion on LC to provide one signal for migration