Gene interactions and pathways from curated databases and text-mining

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COMP — TNF

Text-mined interactions from Literome

Liu et al., Nat Clin Pract Rheumatol 2009 (Arthritis) : In addition, antibodies against ADAMTS-7 or ADAMTS-12 dramatically inhibit tumor necrosis factor induced and interleukin-1beta induced COMP degradation in cartilage explants
Furuzawa-Carballeda et al., Eur J Clin Invest 2009 (Osteoarthritis, Knee) : Polymerized-type I collagen induced an increase of 3- to 6fold cell proliferation ( Ki-67 ), proteoglycans content, and COMP and type II collagen expression, whereas it inhibited IL-1beta and TNF-alpha production
Guo et al., Arthritis Rheum 2010 (Arthritis, Rheumatoid...) : The role of GEP in inhibiting TNFalpha induced ADAMTS-7/ADAMTS-12 expression and COMP degradation in cartilage explants was also analyzed