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BMP2 — PTH

Text-mined interactions from Literome

Nakao et al., Bone 2009 : Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3 ', 5'-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cells ... H89 ( PKA inhibitor ) almost completely abolished PTH actions on BMP signaling ... These results suggest that PTH enhances BMP signaling when PTH induced intracellular cAMP level is maintained for a few hours, accelerating BMP actions to promote osteoblastic function and anabolic actions of new bone formation
Takase et al., Horm Metab Res 2009 : Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells ... So far, it is unclear whether or not PTH could stimulate the expression of bone morphogenetic protein-2 (BMP-2) , a strong mediator for bone formation ... This study was performed to examine if PTH affects BMP-2 expression and to clarify its involvement of the mevalonate pathway ... PTH induced BMP-2 mRNA upregulation was selectively reversed by geranylgeranyl pyrophosphate ( GGPP ) pretreatment, but not by mevalonate pretreatment ... We have now demonstrated for the first time that PTH stimulated BMP-2 mRNA expression via the mevalonate pathway and ROK in osteoblastic MC3T3-E1 cells
Yang et al., Ann N Y Acad Sci 2010 (Bone Diseases, Developmental) : This study provides an in vivo tool to study the role of BMPRII in BMP/Smad signaling and the regulation of this pathway by PTH and Wnts
Zhang et al., PloS one 2011 : Importantly, we found that the PTH-CREB signaling pathway functioned as an effective activator of BMP2 expression, as pharmacologic and genetic modulation of PTH-CREB activity significantly affected BMP2 expression levels in these cells