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CDH13 — NFKB1
Text-mined interactions from Literome
Soloviev et al., J Orthop Res 2002
:
The
role of
p105 protein in
NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles
Li et al., Biochem Biophys Res Commun 2003
:
Overexpression of
p105 and IkappaBgamma
inhibited Casper induced
NF-kappaB activation and potentiated Casper induced apoptosis
Fu et al., J Biol Chem 2004
:
We showed that
p105 ( sr ), which no longer generates p50 and undergoes signal induced degradation, effectively
inhibits all
NF-kappaB activities
Paya et al., Proc Natl Acad Sci U S A 1992
:
These observations indicate that during chronic HIV infection of U937 cells, continuous
NF-kappa B ( p50/p65 ) translocation
results in
p105 promoter upregulation with subsequent cytosolic NF-kappa B accumulation, ready for further translocation
Cohen et al., Biochem Biophys Res Commun 2009
:
p105 plays dual roles in NF-kappaB signaling : in its precursor form it
inhibits NF-kappaB activation, but limited processing by the ubiquitin system generates the p50 active subunit of the transcription factor
McElhinny et al., J Virol 1995
(HIV Infections) :
Transcriptional activity of
p105 is also increased in infected cells and is also
mediated by
NF-kappa B through a specific kappa B motif
Ishikawa et al., J Exp Med 1998
(Inflammation...) :
Loss of
p105 also
led to enhanced constitutive p50 homodimer and inducible
NF-kappaB activities in unstimulated and stimulated cells, respectively