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JUN — RB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of FOS-JUN → Complex of JUN-RB1 (increases)
  Evidence: RB1&CEBPB^taof(CEBPB) Hypophosphorylated pRb binds c-Jun, JunD, and JunB (Nead et al., 1998). This enhances the binding of the Jun family members to c-Fos and stimulates transcriptional activation by the Fos:Jun complexes. A region (amino acids 612?657) in the B-pocket of pRb and a region in the C-pocket can independently bind c-Jun. The binding site in c-Jun is in the leucine zipper region.
• OpenBEL Selventa BEL large corpus: Complex of JUN-RB1 → RB1 (decreases)
  Evidence: RB1&CEBPB^taof(CEBPB) Hypophosphorylated pRb binds c-Jun, JunD, and JunB (Nead et al., 1998). This enhances the binding of the Jun family members to c-Fos and stimulates transcriptional activation by the Fos:Jun complexes. A region (amino acids 612?657) in the B-pocket of pRb and a region in the C-pocket can independently bind c-Jun. The binding site in c-Jun is in the leucine zipper region.
• NCI Pathway Database Regulation of retinoblastoma protein: RB1 (RB1) → JUN (JUN) (modification, collaborate) Nead et al., EMBO J 1998*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1 (RB1) → RB1/JUN complex (RB1-JUN) (modification, collaborate) Nead et al., EMBO J 1998*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: JUN (JUN) → RB1/JUN complex (RB1-JUN) (modification, collaborate) Nead et al., EMBO J 1998*
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: RB1 — JUN Nishitani et al., J Biol Chem 1999*
• IRef Bind_translation Interaction: RB1 — JUN (affinity chromatography technology) Nishitani et al., J Biol Chem 1999*
• IRef Bind_translation Interaction: RB1 — JUN (coimmunoprecipitation) Nishitani et al., J Biol Chem 1999*
• IRef Bind_translation Interaction: RB1 — JUN (two hybrid) Nishitani et al., J Biol Chem 1999*
• IRef Biogrid Interaction: RB1 — JUN (physical association, affinity chromatography technology) Nead et al., EMBO J 1998*
• IRef Biogrid Interaction: RB1 — JUN (direct interaction, pull down) Nead et al., EMBO J 1998*
• IRef Biogrid Interaction: RB1 — JUN (direct interaction, two hybrid) Nishitani et al., J Biol Chem 1999*
• IRef Biogrid Interaction: RB1 — JUN (direct interaction, pull down) Nishitani et al., J Biol Chem 1999*
• IRef Biogrid Interaction: RB1 — JUN (physical association, affinity chromatography technology) Nishitani et al., J Biol Chem 1999*
• IRef Hprd Interaction: RB1 — JUN (in vivo) Nishitani et al., J Biol Chem 1999*, Nead et al., EMBO J 1998*
• IRef Hprd Interaction: RB1 — JUN (in vitro) Nishitani et al., J Biol Chem 1999*, Nead et al., EMBO J 1998*
• IRef Ophid Interaction: RB1 — JUN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: RB1 — JUN (aggregation, confirmational text mining) Jin et al., J Biol Chem 1997*, Nead et al., EMBO J 1998*