Gene interactions and pathways from curated databases and text-mining
CASP8: top 25 interacting genes (chr2:202122753-202152434)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only CASP8-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with CASP8, not among the Top 25
Other genes interacting with CASP8. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

AKT3 ▸ XIAP ▸ IL1B ▸ FASLG ▸ MAPK3 ▸ DIABLO ▸ IL1A ▸
BCL3 ▸ BCL9 ▸ BCL6 ▸ BCL5 ▸ EPHB2 ▸ MAPK1 ▸ IRF6 ▸
MAPK15 ▸ MAPK11 ▸ MAPK9 ▸ MAPK7 ▸ MAPK13 ▸ MAPK4 ▸ MAPK14 ▸
MAPK6 ▸ MAPK12 ▸ MAPK10 ▸ MAPK8 ▸ IFNG ▸ CASP3 ▸ APAF1 ▸
CAPN1 ▸ CAPN10 ▸ CAPN6 ▸ FADD ▸ CAPN2 ▸ CAPN15 ▸ CAPN9 ▸
CAPN7 ▸ CAPN8 ▸ CAPN5 ▸ CAPN11 ▸ CAPN14 ▸ CAPN3 ▸ CAPN13 ▸
CAPN12 ▸ IL18 ▸ STS ▸ ASIP ▸ DNTT ▸ MCL1 ▸ MMP2 ▸
MMP9 ▸ MMP14 ▸ MMP12 ▸ MMP3 ▸ MMP11 ▸ MMP19 ▸ MMP1 ▸
MMP16 ▸ CDKN1A ▸ MMP25 ▸ MMP27 ▸ MMP13 ▸ MMP17 ▸ MMP21 ▸
MMP24 ▸ MMP7 ▸ MMP15 ▸ MMP10 ▸ MMP8 ▸ MMP26 ▸ MMP20 ▸
MMP28 ▸ NLRP3 ▸ CASP9 ▸ JUN ▸ PDCD5 ▸ PDCD11 ▸ CFLAR ▸
CASP12 ▸ RNF19A ▸ PDCD7 ▸ PDCD1 ▸ PDCD6 ▸ PDCD10 ▸ PDCD2 ▸
PDCD4 ▸ CYCS ▸ NA ▸ CASP1 ▸ IGF1 ▸ ANXA5 ▸ CASP2 ▸
PCBD1 ▸ INS ▸ AHSA1 ▸ MPZ ▸ HLA-DRB1 ▸ TGFB1 ▸ CASP6 ▸
PI3 ▸ NLRC4 ▸ CASP7 ▸ PIK3R1 ▸ CASP5 ▸ EPO ▸ CASP14 ▸
PIK3CA ▸ CASP10 ▸ CASP4 ▸ CASP16 ▸ TNFRSF1A ▸ PRKCD ▸ DDIT3 ▸
TAT ▸ NOS2 ▸ PRDX2 ▸ DISC1 ▸ DFFA ▸ DISC2 ▸ PCNA ▸
MYLIP ▸ IL6 ▸ CRK ▸ GSK3B ▸ GRAP2 ▸ IL4 ▸ BIRC2 ▸
EGF ▸ CTSB ▸ CAST ▸ SOD1 ▸ NOS1 ▸ CTNNB1 ▸ IRF1 ▸
EIF2AK2 ▸ VEGFA ▸ IL8 ▸ PAK2 ▸ BID ▸ DFFB ▸ LEP ▸
PTGS2 ▸ NGF ▸ DNASE2 ▸ ABL1 ▸ APP ▸ DNASE1 ▸ ALPI ▸
P2RX7 ▸ ROCK1 ▸ HGF ▸ SOD2 ▸ FOS ▸ BDNF ▸ RIPK1 ▸
MYC ▸ APEH ▸ IL16 ▸ IFI27 ▸ IFNB1 ▸ BCR ▸ CAT ▸
TCF4 ▸ CDK2 ▸ MAP3K1 ▸ NOS3 ▸ HDAC2 ▸ NFKBIA ▸ TCF3 ▸
BMP1 ▸ TCF19 ▸ TCF21 ▸ UPK3B ▸ IL2 ▸ NOD2 ▸ HTRA2 ▸
TCF15 ▸ TCF23 ▸ CTSD ▸ TCF24 ▸ TCF12 ▸ TCF7 ▸ TCF20 ▸
TCF25 ▸ CSF2 ▸ CA2 ▸ RAC1 ▸ MAP2K1 ▸ TLR2 ▸ IL10 ▸
NOX1 ▸ SOD3 ▸ HSPA5 ▸ TLR3 ▸ APOB ▸ CSF3 ▸ BIRC3 ▸
FGF2 ▸ BMP4 ▸ PRKDC ▸ ADCYAP1 ▸ NLRP1 ▸ ATP5O ▸ BIRC7 ▸
GAL ▸ NOX4 ▸ LMNB1 ▸ BAD ▸ HDAC1 ▸ POLDIP2 ▸ STAT1 ▸
CD8A ▸ TLR4 ▸ AIM2 ▸ ITIH4 ▸ ARSK ▸ MAGT1 ▸ CDC73 ▸
CDK5 ▸ LEO1 ▸ KRT18 ▸ PPP2R1A ▸ MST1 ▸ SNAP25 ▸ IL11 ▸
BMP5 ▸ SMPD2 ▸ BMP15 ▸ PAF1 ▸ BMP2 ▸ BMP6 ▸ TLR7 ▸
IL3 ▸ STAT3 ▸ AGTR1 ▸ BMP3 ▸ BMP10 ▸ PDLIM7 ▸ BMP7 ▸
TLR5 ▸ ENDOG ▸ RB1 ▸ NOD1 ▸ HPR ▸ NOX5 ▸ RIPK2 ▸
CTR9 ▸ PPP2CA ▸ PML ▸ WDR61 ▸ IL33 ▸ HSPB1 ▸ GZMB ▸
CD79A ▸ IL15 ▸ NOX3 ▸ PPP2R2B ▸ IL5 ▸ CARD8 ▸ TRAF6 ▸
HMGB1 ▸ CSE ▸ TLR10 ▸ RBBP7 ▸ WAS ▸ CREB1 ▸ RBBP4 ▸
IL20 ▸ CCDC88A ▸ IL21 ▸ TLR1 ▸ APC ▸ TXN ▸ PTX3 ▸
PPARA ▸ GP2 ▸ HTT ▸ ICAM1 ▸ MET ▸ GP6 ▸ JAK2 ▸
EGFR ▸ PLCG1 ▸ LMNB2 ▸ BOC ▸ LPA ▸ GP9 ▸ CXCL9 ▸
TNFRSF1B ▸ PGP ▸ GP5 ▸ CREB5 ▸ SYK ▸ RAD51 ▸ ANXA1 ▸
CD4 ▸ GSN ▸ CDH1 ▸ HIF1A ▸ CREB3 ▸ TLR8 ▸ CDC6 ▸
MAP2K2 ▸ PTX4 ▸ PRNP ▸ IL24 ▸ EIF2S1 ▸ IGF2 ▸ RIPK3 ▸
NPS ▸ BIRC6 ▸ CD79B ▸ LYN ▸ SMARCC1 ▸ IL13 ▸ MUC17 ▸
RENBP ▸ MUC7 ▸ RAF1 ▸ SMARCA4 ▸ CCL2 ▸ TLR9 ▸ PLD1 ▸
ACTL6A ▸ IL22 ▸ ABCC6 ▸ ACHE ▸ SMPD1 ▸ MEFV ▸ HSPD1 ▸
HMOX1 ▸ KDR ▸ CARD11 ▸ CCND1 ▸ MUC16 ▸ SMARCA2 ▸ MUC20 ▸
MUC12 ▸ SMARCE1 ▸ MUC15 ▸ STX1A ▸ FOXO3 ▸ IL26 ▸ CDK8 ▸
ANGPT2 ▸ MUC2 ▸ MUC4 ▸ MUC8 ▸ PPARG ▸ IL32 ▸ MUC13 ▸
MDM2 ▸ MUC22 ▸ BRCA1 ▸ MUC21 ▸ IL31 ▸ IL34 ▸ TLR6 ▸
SMARCD2 ▸ ROCK2 ▸ SMARCC2 ▸ IRF3 ▸ IL7 ▸ IL37 ▸ BECN1 ▸
ARID1A ▸ SYT1 ▸ IKBKB ▸ CARD9 ▸ MSC ▸ IL9 ▸ IL27 ▸
MUC19 ▸ MUC6 ▸ TRAF1 ▸ CDA ▸ TOP1 ▸ GATA1 ▸ IL19 ▸
IL25 ▸ MUC1 ▸ RRAS ▸ SMARCB1 ▸ PAK1 ▸ UCN ▸ CARD6 ▸
SMARCD1 ▸ CEP152 ▸ ME2 ▸ CARD16 ▸ H2AFX ▸ BIRC5 ▸ GRK6 ▸
FOXO1 ▸ PRKACG ▸ CEP250 ▸ CEP85 ▸ CEP70 ▸ EHMT1 ▸ CARD14 ▸
CEP76 ▸ CEP164 ▸ TCHP ▸ MAP2K4 ▸ GDNF ▸ CEP112 ▸ BACE1 ▸
PRKACB ▸ CEP290 ▸ ARC ▸ CEP170 ▸ VIMP ▸ WNT1 ▸ PTHLH ▸
CARD18 ▸ CUL1 ▸ PIDD ▸ PTK2 ▸ CD47 ▸ CEP95 ▸ PXN ▸
HSP90AA1 ▸ CEP68 ▸ CDK4 ▸ PTBP1 ▸ HSF1 ▸ CEP128 ▸ NUP153 ▸
MAP2K3 ▸ VCP ▸ GRK7 ▸ BCL2L12 ▸ CEP63 ▸ DES ▸ ADIPOQ ▸
PSMD10 ▸ MAP2K6 ▸ ARSA ▸ PANX1 ▸ PLOD2 ▸ CEP44 ▸ IRF2 ▸
SEC14L2 ▸ NPY6R ▸ GRB2 ▸ NUP214 ▸ HIST2H2BE ▸ IRF4 ▸ PRKAR2B ▸
PTEN ▸ ATG5 ▸ PRKAR1B ▸ CEP97 ▸ ELAVL1 ▸ SETD2 ▸ VIM ▸
CALM3 ▸ SLC17A5 ▸ CEP135 ▸ SLCO6A1 ▸ TARDBP ▸ SLC9A1 ▸ IRF5 ▸
ANGPT1 ▸ VDAC1 ▸ GRK4 ▸ E2F1 ▸ CARD17 ▸ SKP1 ▸ IL1RN ▸
GRK5 ▸ SOAT1 ▸ CEP78 ▸ DST ▸ CEP41 ▸ GUCY2D ▸ NPM1 ▸
LAT ▸ HUNK ▸ GRB7 ▸ PEA15 ▸ TRAF2 ▸ HIP1 ▸ CEP120 ▸
CEP89 ▸ NUP210 ▸ GRK1 ▸ BIRC8 ▸ PRKCG ▸ MAP2K5 ▸ PRKCA ▸
RASA1 ▸ EPX ▸ CEP72 ▸ GRB10 ▸ CEP104 ▸ CEP57 ▸ CEP192 ▸
MEPE ▸ PRKAR2A ▸ IGF1R ▸ ALB ▸ PRKAR1A ▸ MAP2K7 ▸ MIF ▸
CEP350 ▸ MPST ▸ SETBP1 ▸ CD40 ▸ PLD2 ▸ CEP19 ▸ CARD10 ▸
DERL1 ▸ GRB14 ▸ LYPLA1 ▸ NUP62 ▸ SP1 ▸ CCR7 ▸ TRAF3 ▸
ALK ▸ CEP55 ▸ IKBKG ▸ PSEN1 ▸ TNFRSF10A ▸ RARA ▸ TAC4 ▸
TET3 ▸ PLD3 ▸ MED8 ▸ NAB1 ▸ CPOX ▸ ACSM3 ▸ PC ▸
MED4 ▸ SEPT4 ▸ SMAD7 ▸ CCR2 ▸ SERPINF1 ▸ IRF7 ▸ VIP ▸
MED12 ▸ RAD21 ▸ GHSR ▸ SDS ▸ SERP2 ▸ TRAF5 ▸ HCLS1 ▸
SERPINA1 ▸ CDK12 ▸ WNT3A ▸ CFTR ▸ MLYCD ▸ CYR61 ▸ EDNRA ▸
RAC2 ▸ FHIT ▸ IGFBP3 ▸ CDK16 ▸ CDK19 ▸ NLRC5 ▸ EEF1A2 ▸
IRF8 ▸ SRC ▸ E2F3 ▸ EIF4G1 ▸ RAD52 ▸ HDAC4 ▸ NR0B1 ▸
CDK3 ▸ XAF1 ▸ EMP2 ▸ MAP3K7 ▸ MED6 ▸ PNPLA2 ▸ CDK14 ▸
KLKB1 ▸ MED24 ▸ TSC22D3 ▸ CFL1 ▸ HTRA4 ▸ CDK15 ▸ EMP1 ▸
HDAC6 ▸ NTF4 ▸ QRICH1 ▸ RHO ▸ CDK17 ▸ IRS1 ▸ HIPK2 ▸
CRYAB ▸ CDK6 ▸ BLM ▸ DAXX ▸ CXCL13 ▸ DLG1 ▸ IFI44 ▸
ANXA6 ▸ ATG3 ▸ CCNH ▸ MTOR ▸ VDAC3 ▸ MTA3 ▸ BAG3 ▸
CENPK ▸ CCR4 ▸ MTA2 ▸ CALR ▸ LRRC59 ▸ CTNNBL1 ▸ IFIH1 ▸
KLK3 ▸ TGM2 ▸ PPP1R3A ▸ LRP1 ▸ MED17 ▸ UCP2 ▸ MED7 ▸
CAPNS1 ▸ MED26 ▸ APEX1 ▸ CDC42 ▸ PAEP ▸ ATM ▸ EML2 ▸
CDK7 ▸ IRF9 ▸ PPT1 ▸ RIPK4 ▸ NTN1 ▸ ITCH ▸ PTCH1 ▸
GPX3 ▸ SMAD3 ▸ ADH5 ▸ GPX1 ▸ CTRL ▸ SREBF1 ▸ CCR6 ▸
RAD50 ▸ PIN1 ▸ TAC3 ▸ NUP43 ▸ ANG ▸ TIMP3 ▸ EIF4G3 ▸
CSF1 ▸ ERVK-6 ▸ PAN3 ▸ ADM ▸ CD8B ▸ ACIN1 ▸ STSP1 ▸
ING1 ▸ IARS ▸ CCNC ▸ NUAK1 ▸ PRG3 ▸ S100A12 ▸ ATF2 ▸
FUT1 ▸ GYS1 ▸ APOBEC3D ▸ PRKAG1 ▸ CHUK ▸ ETS2 ▸ MED25 ▸
FAM168B ▸ ID3 ▸ ZGLP1 ▸ LGALS1 ▸ MED13 ▸ TAC1 ▸ E2F2 ▸
SIVA1 ▸ RBL2 ▸ ATF5 ▸ TFAP2A ▸ PRKAA1 ▸ TRAF7 ▸ JAK1 ▸
NLRP7 ▸ RAD18 ▸ CDK1 ▸ MT3 ▸ TNFRSF8 ▸ CPA1 ▸ TNFRSF10B ▸
SHC1 ▸ BCAP31 ▸ MED14 ▸ RUNX3 ▸ RAD17 ▸ ABCD1 ▸ XRCC6 ▸
IDO1 ▸ PGF ▸ ODC1 ▸ PRKAA2 ▸ RANBP2 ▸ CA8 ▸ NACA ▸
RAD1 ▸ MED1 ▸ CCL19 ▸ GPI ▸ SLPI ▸ STC1 ▸ CCR3 ▸
TRAF4 ▸ DIDO1 ▸ PRKAG2 ▸ HRD ▸ APIP ▸ SPP1 ▸ PLD5 ▸
CCR10 ▸ TYR ▸ CDK9 ▸ TET2 ▸ NLRP5 ▸ ACAD8 ▸ PTPN11 ▸
DAPK2 ▸ PRG4 ▸ BNIP3 ▸ QRICH2 ▸ SMAD4 ▸ STX2 ▸ GJA1 ▸
DYRK1A ▸ PLD6 ▸ PMEL ▸ SREBF2 ▸ IFNA2 ▸ FOXP3 ▸ EIF4G2 ▸
MED15 ▸ SUB1 ▸ GNA11 ▸ GLI1 ▸ WNK1 ▸ GNRH1 ▸ MST1R ▸
MME ▸ PLD4 ▸ CDK13 ▸ MICE ▸ GYS2 ▸ IAPP ▸ NPPA ▸
CDCA5 ▸ CALML3 ▸ COP ▸ PARG ▸ MED23 ▸ TGFB3 ▸ HMGCR ▸
EMP3 ▸ C22orf29 ▸ CCR1 ▸ ETS1 ▸ FAF1 ▸ NANOS2 ▸ TRA ▸
GRP ▸ HRK ▸ MAP2 ▸ PLK1 ▸ TMED7 ▸ TNFSF12 ▸ DAP3 ▸
CTNND1 ▸ NAIP ▸ PDGFB ▸ CXCL17 ▸ CCK ▸ AIP ▸ THBS1 ▸
KLF4 ▸ MTA1 ▸ CCR9 ▸ DHCR24 ▸ APOE ▸ PSENEN ▸ AFP ▸
HTRA3 ▸ NANOG ▸ PRKAB1 ▸ PAN2 ▸ SAA1 ▸ TET1 ▸ CIB1 ▸
CTSL ▸ NTF3 ▸ CCR8 ▸ CISH ▸ CDK20 ▸ CD2 ▸ HTRA1 ▸
CALB1 ▸ MT4 ▸ GSTT1 ▸ SATB1 ▸ PSMB9 ▸ PRG2 ▸ PRKAB2 ▸
KMT2A ▸ RAB5A ▸ DNAJC5 ▸ VDAC2 ▸ ANP32A ▸ RAC3 ▸ MED21 ▸
NAB2 ▸ CDK18 ▸ CCR5 ▸ SERPINB9 ▸ CDK10 ▸ JAK3 ▸ GRIA1 ▸
TUBA1A ▸ MAPT ▸ PLEC ▸ ATG4D ▸ COL11A1 ▸ MALT1 ▸ USP54 ▸
TICAM2 ▸ ATAD3A ▸ TRIM25 ▸ COPS6 ▸ ATN1 ▸ USP2 ▸ OTUD7B ▸
COL6A2 ▸ BNIP3L ▸ COL4A6 ▸ RAB10 ▸ COL4A3 ▸ IL1R2 ▸ ITGB1 ▸
UBB ▸ KHDRBS1 ▸ EIF4A1 ▸ MAP3K14 ▸ COL6A1 ▸ IQGAP1 ▸ ITGA2 ▸
IFT57 ▸ KARS ▸ PARK2 ▸ PTPN13 ▸ EIF3S10 ▸ PIDD1 ▸ IL1R1 ▸
KRR1 ▸ NUCB1 ▸ COL2A1 ▸ EP300 ▸ CHD3 ▸ ACTG2 ▸ TFCP2 ▸
MAP4K4 ▸ COL5A2 ▸ PLIN4 ▸ PRKCI ▸ RPS27 ▸ COL3A1 ▸ NCL ▸
COL11A2 ▸ NEFH ▸ PARK7 ▸ PYCARD ▸ IRS4 ▸ STK24 ▸ CASP8AP2 ▸
EZR ▸ AR ▸ TNFRSF25 ▸ CD14 ▸ MSN ▸ RPS27L ▸ UBC ▸
MAP1LC3A ▸ CD3E ▸ PCYT1A ▸ COL5A1 ▸ TRIM28 ▸ RALGDS ▸ COL1A2 ▸
COL6A3 ▸ NR1H4 ▸ RNF34 ▸ CD3D ▸ COL4A1 ▸ PICALM ▸ CUL3 ▸
PDIA6 ▸ COL4A4 ▸ DEDD2 ▸ TNFAIP3 ▸ ITGAV ▸ TUBB ▸ MYO9A ▸
SYF2 ▸ TOPORS ▸ COL4A5 ▸ HIST1H4A ▸ CDK11A ▸ BFAR ▸ PIAS1 ▸
MAP1LC3B ▸ ARHGDIA ▸ PTPN6 ▸ NUCB2 ▸ FIS1 ▸ ACTA2 ▸ CDK11B ▸
CD247 ▸ COL7A1 ▸ CRADD ▸ CLTC ▸ DDX28 ▸ HNRNPH2 ▸ UBE2L3 ▸
RALBP1 ▸ TUBA1C ▸ NOL3 ▸ ITGB3 ▸ YES1 ▸ UBR5 ▸ TNFSF14 ▸
LY96 ▸ COL1A1 ▸ CLIP3 ▸ EDA2R ▸ PLA2G4B ▸ UBE2D1 ▸ RNF135 ▸
CD3G ▸ SQSTM1 ▸ SPARC ▸ DNAJC7 ▸ SORBS1 ▸
Data information
Please see the Gene Interactions Track Manual.