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RAC1 — SERPINE1
Text-mined interactions from Literome
Diebold et al., Thromb Haemost 2008
:
Expression of dominant negative
Rac-1 ( RacT17N )
prevented thrombin induced
PAI-1 expression whereas constitutively active RacG12V enhanced PAI-1 levels ... Finally,
upregulation of
PAI-1 by
Rac-1 and HIF-1 was essential for thrombin stimulated proliferation of PASMC
Ando et al., J Atheroscler Thromb 2011
:
Inhibition of RhoA attenuated thrombin triggered [ Ca ( 2+ ) ] ( i ) increase and TF and PAI-1 expression in HAECs, whereas thrombin triggered ROS generation and TF and
PAI-1 expression were
blocked by inhibition of
Rac1
Petry et al., Thromb Haemost 2012
:
Thus, our findings show that capillary formation induced by thrombin via
Rac1 dependent
activation of HIF-1 and
PAI-1 is limited by the concomitant release of NO which reduced ROS bioavailability