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PCSK1 — STAT3

Text-mined interactions from Literome

Fox et al., Mol Endocrinol 2008 : Studies herein reveal that leptin induced PC1/3 gene expression is abrogated in N2KO mice, and that in a hypothalamic cell line both STAT3 and Nhlh2 are required for the full transcriptional response of a PC1/3 reporter gene after leptin stimulation
Talbot et al., Proc Natl Acad Sci U S A 2011 (Disease Models, Animal...) : Here we show that membrane anchored PC1 activates STAT3 in a JAK2 dependent manner, leading to tyrosine phosphorylation and transcriptional activity ... These results indicate that STAT3 signaling is regulated by PC1 and is a driving factor for renal epithelial proliferation during normal renal development and during cyst growth