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CTNNB1 — MYC
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MYC
→
CTNNB1
(decreases, MYC Activity)
Evidence: we next investigated target genes of b-catenin, in particular, c-Jun, c-Myc, and cyclin D1, and their possible contribution to the anti-MM effect of enzastaurin. Our results show that b-catenin induces c-Jun, whereas c-Myc was markedly down-regulated #(this is protein - western blots in fig 3A)
-
FastForward regulation:
CTNNB1
→
MYC
(transcriptional regulation, increase)
Ciznadija et al., Cell Death Differ 2009*
Evidence: PROMACTIVITY, DNABINDING
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FastForward regulation:
TCF4, CTNNB1
→
MYC
(transcriptional regulation, increase)
Yochum et al., Proc Natl Acad Sci U S A 2010*
Evidence: REG, DNABINDING
-
FastForward regulation:
TCF4, CTNNB1
→
MYC
(transcriptional regulation, increase)
Yochum et al., J Biol Chem 2007*
Evidence: REG, DNABINDING
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF3/beta catenin/TERT/BRG1 complex (CTNNB1-TCF7L1)
→
MYC (MYC)
(transcription, activates)
Park et al., Nature 2009
Evidence: reporter gene, physical interaction, other species
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
beta catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 complex (CTNNB1-HNF1A-CTBP1-CREBBP-TLE1-AES)
→
MYC (MYC)
(transcription, activates)
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3)
→
MYC (MYC)
(transcription, activates)
Gan et al., J Cell Biol 2008
Evidence: reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Innatedb Interaction:
Complex of CTNNB1-ESR1-EZH2-MYC
(unknown, -)
Shi et al., Mol Cell Biol 2007*
-
IRef Innatedb Interaction:
MYC
—
CTNNB1
(unknown, -)
Dutta-Simmons et al., Blood 2009*
-
IRef Innatedb Interaction:
MYC
—
CTNNB1
(unknown, -)
Lim et al., Cancer Res 2008*
-
IRef Innatedb Interaction:
MYC
—
CTNNB1
(unknown, -)
Yan et al., J Biol Chem 2006*
-
IRef Innatedb Interaction:
MYC
—
CTNNB1
(unknown, -)
Nateri et al., Nature 2005
Text-mined interactions from Literome
Jaiswal et al., Oncogene 2002
(Colonic Neoplasms) :
We further investigated the association of the
beta-catenin mediated
c-Myc expression and the cell-cell adhesion pathways in curcumin induced G ( 2 ) /M arrest and apoptosis in HCT-116 cells
Saldanha et al., Br J Dermatol 2004
(Carcinoma, Basal Cell...) :
In turn, nuclear
beta-catenin can
increase expression of
MYC and cyclin D1, thus potentially altering proliferation
Ju et al., Cancer Res 2005
(Intestinal Neoplasms) :
Treatment of HT29 human colon cancer cells with EGCG ( 12.5 or 20 micromol/L at different times ) also increased protein levels of E-cadherin by 27 % to 58 %,
induced the translocation of
beta-catenin from nucleus to cytoplasm and plasma membrane, and decreased
c-Myc and cyclin D1 ( 20 micromol/L EGCG for 24 hours )
Noubissi et al., Nature 2006
:
CRD-BP is essential for the
induction of both betaTrCP1 and
c-Myc by
beta-catenin signalling in colorectal cancer cells
Li et al., Oncogene 2007
(Colonic Neoplasms) :
As expected,
beta-catenin induced its downstream target
c-Myc , as well as E2F1 and Bcl-2, and this was blocked by siRNA to c-Myc or E2F1
Alves-Guerra et al., Cancer Res 2007
(Colonic Neoplasms) :
Finally, we show that the knockdown of Mastermind-like family proteins in colonic carcinoma cells results in cell death by affecting
beta-catenin induced expression of cyclin D1 and
c-Myc
Momota et al., Oncogene 2008
(Disease Models, Animal...) :
As elevated
c-Myc expression,
activation of
Wnt/beta-catenin signaling and dysfunction of p53 are seen in human PNETs, we investigated what role these abnormalities have in the formation of PNETs
Palozza et al., Carcinogenesis 2008
(Colonic Neoplasms...) :
Silencing of
c-Myc attenuated beta-carotene induced apoptosis and
beta-catenin expression
Ciznadija et al., Cell Death Differ 2009
(Adenoma...) :
We explored the relationship between activated Wnt signaling and MYB in regulating MYC and found activated
beta-catenin in combination with MYB
induces robust upregulation of
MYC promoter activity, as well as endogenous MYC mRNA and protein expression, in human cells
Schmeisser et al., J Biol Chem 2009
:
Upon N-methyl-D-aspartate receptor dependent activation, LAPSER1 and
beta-catenin comigrate from the postsynaptic density to the nucleus and
induce the transcription and translation of known beta-catenin target genes, including Tcfe2a and
c-Myc
Kaur et al., Neoplasia (New York, N.Y.) 2010
(Colorectal Neoplasms) :
Other studies, therefore, were performed only in SW480 cells where silibinin significantly decreased
beta-catenin dependent T-cell factor-4 (TCF-4) transcriptional activity and protein expression of beta-catenin target genes such as
c-Myc and cyclin D1