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CCND1 — RAF1

Text-mined interactions from Literome

Guillemot et al., J Biol Chem 2000 : Using a pharmacological and a co-transfection approach, we found that p21(ras), Raf-1 , phosphatidylinositol 3-kinase and also the catalytic activity of SHP-2 and its Src homology 2 domains are required for cyclin D1 promoter/reporter gene activation by Ang II through the regulation of MAPK/ERK activity
Guillemot et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Taken together, these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves PI3K and SHP-2
Yu et al., Blood 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : These events were accompanied by down-regulation of the Raf-1/mitogen induced extracellular kinase ( MEK ) /extracellular signal related kinase ( ERK ) pathway as well as diminished expression of Bcr/Abl and cyclin D1 , cleavage of p21CIP1 and phosphorylation of the retinoblastoma protein ( pRb ), and induction of the stress related kinases Jun kinase (JNK) and p38 mitogen activated protein kinase ( MAPK )
Kerkhoff et al., Mol Cell Biol 1997 (Cell Transformation, Neoplastic) : The activation of the c-Raf-1-BxB-ER protein leads to an accumulation of high levels of cyclin D1 protein and a repression of the p27Kip1 cyclin dependent kinase inhibitor under all culture conditions tested