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NLRP3 — TNF
Text-mined interactions from Literome
O'Connor et al., J Immunol 2003
:
We report that
TNF-alpha and ligands recognized by multiple Toll-like receptors rapidly
induce CIAS1 gene expression in primary human monocytes
Rosengren et al., Ann Rheum Dis 2005
(Arthritis, Rheumatoid...) :
FLS from RA and OA tissue expressed low baseline levels of
cryopyrin transcripts that were
induced by
tumour necrosis factor alpha (TNFalpha)
Franchi et al., Eur J Immunol 2008
(Inflammation) :
The requirement of the Nlrp3 inflammasome was specific for IL-1beta in that secretion of
TNF-alpha was
independent of
Nlrp3 or Asc
Qiu et al., Innate Immun 2011
(Carcinoma, Squamous Cell) :
Stimulation of
NLRP3 with E. coli RNA
led to the highest induction of
TNF-a , IL-6, IL-12p40, RANTES and IFN-ß, whereas TLR7, TLR3, TLR9, NOD1 and NOD2 agonists had lower effects