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IDO1 — TNF
Text-mined interactions from Literome
Däubener et al., Adv Exp Med Biol 1999
:
For example we have found that TNF-alpha
enhances IFN-gamma induced
IDO activity and antimicrobial effect in human glioblastoma cells whereas both IFN-gamma mediated effects were blocked by
TNF-alpha as well as by IL-1 in a human uroepithelial cell line ... We were able to show that the IL-1 and
TNF-alpha mediated
inhibition of IFN-gamma induced
IDO activity in uroepithelial cells is due to stimulation of inducible nitric oxide synthase ... In human astrocytoma cells, IL-1 and
TNF-alpha did not
inhibit IDO activity and in concordance with this finding these cells did not show a detectable nitric oxide production
Currier et al., J Interferon Cytokine Res 2000
:
Our objectives were to characterize the antichlamydial
effect of
tumor necrosis factor-alpha (TNF-alpha) on IFN induced
IDO activity and to establish the relationship between LPS and TNF-alpha in IDO potentiation ... Both LPS and
TNF-alpha enhanced
IDO activity and IDO mRNA expression, with maximal IDO induction at 100 ng/ml LPS or 5 ng/ml TNF-alpha ... Anti-TNF-alpha failed to neutralize the effects of LPS treatment, and insufficient TNF-alpha or IL-1 was produced by LPS treated THP-1 cells to account for the enhancing effect of LPS, indicating that the effect of LPS on
IDO was
independent of
TNF-alpha and IL-1
Babcock et al., Cytokine 2000
:
Interferon (IFN)-gamma induced
indoleamine 2,3-dioxygenase (IDO) activity is
enhanced synergistically by interleukin (IL-)1,
tumor necrosis factor-alpha (TNF-alpha) and LPS in IFN treated macrophages by increasing IDO mRNA concentration ... These studies demonstrate that IFN treated HeLa cells also exhibit dose dependent
enhancement of
IDO induction by
TNF-alpha and IL-1, with maximal effects at concentrations of 5 ng/ml and 3 ng/ml, respectively
Fujigaki et al., Eur J Immunol 2001
:
The present study used IFN-gamma or TNF-alpha gene disrupted mice and IFN-gamma antibody treated mice to demonstrate that lipopolysaccharide (LPS) induced systemic
IDO is largely
dependent on
TNF-alpha rather than IFN-gamma
Shemi et al., J Endotoxin Res 2000
:
The
effect of pentoxifylline (PXF), nimesulide ( NIM ),
indomethacin (INDO) and dexamethasone ( DEX ) on the regulation of PGE2 and
TNF-alpha production was tested
Robinson et al., J Interferon Cytokine Res 2003
:
Tumor necrosis factor-alpha (TNF-alpha) synergistically
enhances the
IDO activity induced by IFN-gamma at the level of transcription in human epithelial cells
Adams et al., Microbes Infect 2004
:
We found that IFN-gamma induces a strong activation of the tryptophan degrading enzyme indoleamine 2,3-dioxygenase (IDO) and in addition, that the IFN-gamma induced
IDO activity was enhanced in the
presence of
TNF-alpha
Fieren et al., Immunol Lett 1992
(Peritonitis) :
In view of the interregulatory effects between PGE2 and macrophage cytokines ( IL-1 beta and TNF alpha ) in their production, we examined in the present work to what extent the LPS induced release of either IL-1 beta or
TNF alpha in vitro from CAPD originated peritoneal macrophages is
affected by graded doses of exogenous PGE2 ( range 0-1000 ng/ml ) and by the cyclooxygenase inhibitor
indomethacin (INDO) ( 10 ( -6 ) M ) ...
INDO induced an approx. two-fold increase in
TNF alpha release, but had no effect on IL-1 beta release
Robinson et al., J Interferon Cytokine Res 2005
:
In human epithelial cells, interferon-gamma (IFN-gamma) induced
IDO expression is transcriptionally
enhanced by
tumor necrosis factor-alpha(TNF-alpha) ... A transcriptional reporter containing green fluorescent protein ( GFP ) under the control of the IDO regulatory region was used to analyze the contribution of these enhancer elements to synergistic
IDO gene expression in
response to IFN-gamma and
TNF-alpha
Shirey et al., J Interferon Cytokine Res 2006
:
Furthermore,
tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) synergistically
increase IFN induced
IDO activity
Spalletta et al., Mol Psychiatry 2006
(Brain Ischemia...) :
The increased production of proinflammatory cytokines such as IL-1beta,
TNF-alpha or IL-18 resulting from stroke may
lead to an amplification of the inflammatory process, particularly in limbic areas, and widespread activation of
indoleamine 2,3-dioxygenase (IDO) and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex, polar temporal cortex and basal ganglia
Shirey et al., Infect Immun 2006
:
Gamma interferon ( IFN-gamma ) -induced
indoleamine dioxygenase (IDO) , which inhibits chlamydial replication by reducing the availability of tryptophan, is
up-regulated by interleukin-1beta (IL-1beta) and
tumor necrosis factor alpha (TNF-alpha)
Popov et al., J Clin Invest 2006
(Granuloma...) :
Reporting on our use of the clinically applied anti-TNF-alpha antibody infliximab, we further demonstrate in vitro that
IDO induction is
TNF-alpha dependent
Oxenkrug et al., Ann N Y Acad Sci 2007
:
Although IDO is strictly an IFN-gamma induced gene product,
tumor necrosis factor alpha (TNF-alpha) can synergistically
increase the transcriptional activation of the
IDO gene in response to IFN-gamma
O'Connor et al., J Neurosci 2009
:
Interferon-gamma and
tumor necrosis factor-alpha mediate the upregulation of
indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin
Njau et al., Microbes Infect 2009
(Chlamydophila Infections) :
Reporting on our use of anti-TNF-alpha antibody adalimumab and varying concentrations of TNF-alpha, we further demonstrate that
IDO induction following infection of DCs with C. pneumoniae is
TNF-alpha dependent
Däubener et al., Eur J Immunol 1996
(Brain Neoplasms...) :
We therefore conclude that both
TNF-alpha and IFN-gamma may be
involved in the defense against cerebral toxoplasmosis by inducing
IDO activity as an antiparasitic effector mechanism in brain cells