◀ Back to EGF
EGF — EPS15
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
EPS15
→
EGF
(increases)
de Melker et al., J Cell Sci 2004*
Evidence: EGF-induced phosphorylation of Eps15, as well as recruitment of Eps15 to the plasma membrane and its co-localization with the EGF receptor in endosomes required the ubiquitin ligase activity of c-Cbl.
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
→
EPS15 (EPS15)
(modification, activates)
Torrisi et al., Mol Biol Cell 1999*
Evidence: assay, physical interaction
-
Reactome Reaction:
EGF
→
EPS15
(indirect_complex)
Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Haglund et al., EMBO Rep 2005
-
Reactome Reaction:
EGF
→
EPS15
(reaction)
Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005
Text-mined interactions from Literome
de Melker et al., J Cell Sci 2004
:
EGF induced phosphorylation of
Eps15 , as well as recruitment of Eps15 to the plasma membrane and its co-localization with the EGF receptor in endosomes required the ubiquitin ligase activity of c-Cbl
van Delft et al., J Cell Biol 1997
:
In this report, we show that activation of the EGF receptor by either
EGF or TGF-alpha
results in phosphorylation of
Eps15
van Delft et al., J Biol Chem 1997
:
Our results establish ubiquitination as a second form of
EGF stimulated covalent modification of
Eps15