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HPR — NEUROD6

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Samuel et al., J Neurochem 2008 : We asked the question whether the mitogen activated protein kinase ( MAPK ) pathway is involved in the regulation of the 4HPR induced neuronal differentiation of RPE ( ARPE-19 ) cells ... Both U0126 and the suppression of ERK1/2 expression with small interfering RNA effectively blocked the 4HPR induced neuronal differentiation of RPE cells and the expression of calretinin ... Taken together, our results clearly demonstrate that c-Raf/MEK1/2 signaling cascade involving ERK1/2 plays a central role in mediating the 4HPR induced neuronal differentiation and calretinin expression in the human ARPE-19 retinal pigment epithelial cell line
Samuel et al., J Cell Physiol 2010 : IGFBP5 is expressed in human RPE cells, and its expression, mRNA as well as protein, is greatly decreased during the 4HPR induced neuronal differentiation ... The overexpression of transcription factor CCAAT/enhancer binding protein-beta ( C/EBPbeta ) inhibited the 4HPR induced down-regulation of IGFBP5 expression and the neuronal differentiation of RPE cells ... Thus, our results clearly demonstrate that the IGFBP5 expression is down-regulated during 4HPR induced neuronal differentiation of human RPE cells through a MAPK signal transduction pathway involving C/EBPbeta