Gene interactions and pathways from curated databases and text-mining

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CRK — PRL

Text-mined interactions from Literome

Gerlo et al., Cell Signal 2005 : We postulate that cAMP induces PRL expression via two different signalling pathways : a PKA dependent pathway leading to the phosphorylation of CREB, and a PKA independent pathway leading to the phosphorylation of p38
Lee et al., Cancer Res 2005 (MAP Kinase Signaling System) : 16-kDa PRL effectively inhibited IL-1beta-inducible p38 MAPK phosphorylation, resulting in blocking Stat1 serine phosphorylation, its subsequent nuclear translocation and activation of the Stat1 target gene IRF-1