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CRK — MET

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CRK-GAB1 → MET (increases, CRK/GAB1 Activity)
  Evidence: Page 54 - "Crk appears to bind Gab1 in response to Met but not other receptor tyrosine kinases."
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRK (CRK) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRK (CRK) → HGF(dimer)/MET(dimer)/GAB1/CRK complex (MET-GAB1-CRK-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) → HGF(dimer)/MET(dimer)/GAB1/CRK complex (MET-GAB1-CRK-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Crk/p130 Cas complex (BCAR1-CRK) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Garcia-Guzman et al., Oncogene 1999*, Riordan et al., Biochem J 2000*, Lamorte et al., Oncogene 2000
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer) complex (MET-HGF) → CRK (CRK) (modification, activates) Garcia-Guzman et al., Oncogene 1999*, Riordan et al., Biochem J 2000*, Lamorte et al., Oncogene 2000
  Evidence: physical interaction

Text-mined interactions from Literome

Lamorte et al., Oncogene 2000 (Cell Transformation, Neoplastic) : We propose that the loss of adhesion dependent signals required for cell cycle progression is compensated through Met induced Gab1/Crk signals
Petrelli et al., Nature 2002 : Cbl, in turn, binds and ubiquitinates activated HGF receptor , and by recruiting the endophilin-CIN85 complex , it regulates receptor internalization
Brusevold et al., J Oral Pathol Med 2012 (Carcinoma, Squamous Cell...) : In the E10 cell line, EGF and HGF induced phosphorylation of EGF receptor (EGFR) and Met , respectively, phosphorylation of ERK1/2, p38 and Akt, and dose dependent activation of cell migration