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The TGFß induced phosphorylation and activation of p38 mitogen activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1
Nagata et al., EMBO J 1998
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Transfection of MLK2 into COS cells leads to strong and constitutive activation of the JNK ( c-Jun N-terminal kinase ) MAP kinase cascade, but also to activation of ERK ( extracellular signal regulated kinase ) and p38