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IL33 — TNFSF11
Text-mined interactions from Literome
Schulze et al., J Bone Miner Res 2011
(Bone Resorption) :
Since we observed that the expression of IL-33 increases during osteoblast differentiation, we analyzed its possible influence on bone formation and observed that
IL-33 did not affect matrix mineralization but
enhanced the expression of
Tnfsf11 , the gene encoding RANKL
Zheng et al., Biochem Pharmacol 2013
(Bone Resorption) :
Coumermycin A1 also abrogated
RANKL induced expression of
interleukin-1ß , tumor necrosis factor-a, and inducible nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments