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CDKN1A — STAT3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
O'Farrell et al., J Immunol 2000
:
These data indicate that
Stat3 dependent induction of p19INK4D and Stat3 independent induction of
p21CIP1 are important components of the mechanism by which IL-10 blocks proliferation in macrophages
Vancurova et al., J Virol 2002
(Laryngeal Neoplasms...) :
Increased NF-kappaB activity and cytoplasmic accumulation of
p21 ( CIP1/WAF1 ) might counteract death promoting effects elicited by overexpressed PTEN and
reduced activation of Akt and
STAT3 previously noted in these tissues
Barré et al., J Biol Chem 2003
(Cell Transformation, Neoplastic) :
To reconcile these observations, one would predict that the
STAT3 mediated
activation of
p21 ( waf1 ) is lost during cell transformation ... In this study, we show that upon IL-6 stimulation of glioblastoma cells,
STAT3 does not
activate the expression of the
p21 ( waf1 ) gene, whereas the expression of the myc gene remains unaltered ... In these cells, the kinase blocked the
STAT3 mediated expression of the
p21 ( waf1 ) gene by inhibiting the recruitment of CREB binding protein and the type II RNA polymerase, without having any effects on the loading of STAT3 and its cofactor NcoA/SRC1a
Majumder et al., FEBS Lett 2003
(Cystitis...) :
HCV NS5A protein possesses many intriguing properties, including sequestration of p53 in the cytoplasm, downregulation of
p21 protein,
activation of
STAT3 , and inhibition of tumor necrosis factor-alpha mediated apoptosis
Giraud et al., Oncogene 2004
:
Implication of BRG1 and cdk9 in the
STAT3 mediated activation of the
p21waf1 gene ... We have previously reported that
STAT3 activates the expression of the
p21waf1 gene through its association with the NcoA/SRC1a and CBP coactivators ... In this study, we explore the role of BRG1, a component of the SWI/SNF chromatin remodeling complex, and the role of cdk9, a component of the elongation factor P-TEFb, in the
STAT3 mediated expression of
p21waf1
Bienvenu et al., Mol Biol Cell 2005
(Breast Neoplasms) :
Moreover, the
STAT3 mediated activation of
p21waf1 was also inhibited in breast cancer cells containing elevated levels of cyclin D1
Moran et al., J Surg Res 2008
(Carcinoma, Hepatocellular...) :
These data demonstrate that, while IL-6 plays a central role in hepatocyte priming and proliferation in vivo, the pronounced inhibition of proliferation observed in HCC cells occurs due to
IL-6-STAT3 dependent regulation of cdk2/cdk4 activity and
p21 ( waf1/cip1 ) expression
Cao et al., Am J Respir Cell Mol Biol 2010
:
Using chromatin immunoprecipitation assays and expression of a dominant negative Stat3 mutant, we show that activation of
Stat3 and its binding to the p21 promoter are
required for DEP induced expression of
p21 , suggesting that Stat3 plays an essential role in the induction of p21 by DEP. Additional experiments demonstrated that activation of p21 gene expression is dependent on the activation of epidermal growth factor receptor and Src kinase activities
Loh et al., PloS one 2012
(Muscular Dystrophy, Duchenne) :
STAT3 activation
resulted in
p21 and p27 downregulation in a S1PR2 dependent fashion in myoblasts
Fukada et al., EMBO J 1998
:
Furthermore, unexpectedly, we found that gp130 could
induce the expression of
p21 when
STAT3 activation was suppressed