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FYN — JAK2
Pathways - manually collected, often from reviews:
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NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2)
→
Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, activates)
Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
Evidence: mutant phenotype, assay, physical interaction
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Reactome Reaction:
FYN
→
JAK2
(indirect_complex)
Brizzi et al., J Biol Chem 1999, Ning et al., Oncogene 2001, Argetsinger et al., Mol Cell Biol 2004, Argetsinger et al., Mol Endocrinol 2010, Weiler et al., Blood 1996, Feng et al., Mol Cell Biol 1997, Deberry et al., Biochem J 1997
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Reactome Reaction:
FYN
→
JAK2
(reaction)
Argetsinger et al., Mol Cell Biol 2004, Argetsinger et al., Mol Endocrinol 2010, Weiler et al., Blood 1996, Feng et al., Mol Cell Biol 1997
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sayeski et al., J Biol Chem 1999
:
A catalytically active
Jak2 is
required for the angiotensin II-dependent activation of
Fyn ... Last, in vivo studies in vascular smooth muscle cells show that, in response to angiotensin II,
Jak2 activation is
required for
Fyn activation and induction of the c-fos gene
Kline et al., J Biol Chem 1999
(Breast Neoplasms) :
In contrast, the intermediate PRLr transfectants showed equivalent levels of
Jak2 activation but only minimal
activation of
Fyn