Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
NOS2
→
Complex of HSPA8-NOS2
(decreases, HSPA8/NOS2 Activity)
Evidence: geldanamycin, a member of ansamycin family, has been shown to induce HSP- 70i overexpression and then subsequently to inhibit iNOS expression, to reduce cellular caspase-3 activity, and to preserve cellular ATP levels. HSP-70i is found to couple to iNOS and its transcription factor. Therefore, the complex formation between HSP-70i and iNOS may be a novel mechanism for protection from hemorrhage/resuscitation-induced injury.