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HMGA1 — NOS2

Text-mined interactions from Literome

Perrella et al., J Biol Chem 1999 : Furthermore, overexpression of HMG-I(Y) potentiated iNOS promoter/enhancer activity by p50 and p65 in transfection experiments, suggesting that HMG-I(Y) contributes to the transactivation of iNOS by NF-kappaB
Pellacani et al., J Biol Chem 2001 : The aim of the present study was to determine whether regulation of HMG-I(Y) by TGF-beta1 contributes to the TGF-beta1 mediated suppression of NOS2 ... To determine whether the down-regulation of HMG-I(Y) contributed to a decrease in NOS2 gene transactivation by TGF-beta1, we performed cotransfection experiments ... The effect of TGF-beta1 on NOS2 gene transactivation was not related to a decrease in binding of HMG-I(Y) to the promoter of the NOS2 gene, but due to a decrease in endogenous HMG-I(Y) protein ... This down-regulation of HMG-I(Y) contributes to the TGF-beta1 mediated decrease in NOS2 gene transactivation by proinflammatory stimuli