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CAT — NOS2

Text-mined interactions from Literome

Lim et al., Free Radic Biol Med 2001 (Helicobacter Infections) : AGS cells were treated with antisense oligonucleotide ( AS ODN ) for NF-kappaB subunit p50, an antioxidant enzyme catalase , an inhibitor of NF-kappaB activation pyrrolidine dithiocarbamate ( PDTC ), iNOS inhibitors N ( G ) -nitro-L-arginine-methyl ester ( L-NAME ) and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine ( AMT ), a peroxynitrite donor SIN-1, and a nitric oxide donor NOC-18 in the presence or absence of H. pylori
Han et al., Nitric Oxide 2001 : H ( 2 ) O ( 2 ) enhanced iNOS expression and NO production in peritoneal macrophages when added with interferon-gamma, and the effect of H ( 2 ) O ( 2 ) was inhibited by catalase and PDTC
Pawate et al., J Neurosci Res 2004 (Encephalitis...) : Exogenous catalase but not superoxide dismutase suppressed the basal activity and completely blocked induced levels of NO/iNOS , suggesting that hydrogen peroxide is the ROS involved
Jang et al., Biochem Pharmacol 2004 : Catalase induces the expression of inducible nitric oxide synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells ... Of interest, catalase induced iNOS protein expression was abrogated through inactivation of NF-kappaB pathway by MG132 or BAY 11-7085 and PI3K pathway by LY294002 or wortmannin, respectively ... In particular, blockage of PI3K pathway by LY294002 down-regulated iNOS transcription and steady-state iNOS mRNA levels as well as iNOS mRNA stability induced by catalase, suggesting regulation of PI3K pathway in catalase induced iNOS expression at the levels of iNOS transcription, steady-state mRNA status, and mRNA stability ... Together, these results demonstrate for the first time that catalase induces iNOS expression in Raw cells, which seems to be associated with the increase of iNOS transcription and mRNA stability as well as the activation of NF-kappaB and PI3K signaling pathways
Jang et al., Cell Signal 2005 : Catalase induces COX-2 or iNOS expression in some type of cells, but the mechanism remains unclear ... Here we investigated the effect of catalase on COX-2 and iNOS expression in BV2 microglia and the inductive mechanism associated ... Importantly, catalase induced COX-2 and iNOS expression needed activations of NF-kappaB, PI3K/AKT, and JNKs, which were important for the transcriptional up-regulation of COX-2 and iNOS ... Notably, rapamycin inhibition of p70S6K led to down-regulation of COX-2 and iNOS protein expression, but not steady-state mRNA expression and transcription, induced by catalase , suggesting that p70S6K is involved in increased COX-2 and iNOS mRNA translation by catalase ... These data collectively suggest catalase induced COX-2 and iNOS expression in BV2 microglia is, in part at least, mediated through activation of multiple signaling proteins
Hu et al., J Ethnopharmacol 2008 (Drug-Induced Liver Injury) : Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content, but not superoxide dismutase ( SOD ) activity, and it inhibited the CCl ( 4 ) -induced high expression of iNOS and TNF-alpha in hepatic tissue
Di Naso et al., Exp Diabetes Res 2010 (Diabetes Mellitus, Experimental) : Lipoperoxidation (LPO), and superoxide dismutase ( SOD ), catalase , and glutathione peroxidase activities were measured in the pulmonary tissue, as well as the presence of inducible nitric oxide synthase (iNOS) , through immunohistochemistry
Rengasamy et al., Biochem Pharmacol 1994 : Effect of hydrogen peroxide and catalase on rat cerebellum nitric oxide synthase ... The effect of H2O2 and catalase on isolated rat cerebellum nitric oxide ( NO ) synthase activity was determined by measuring the conversion of L- [ 3H ] arginine to L- [ 3H ] citrulline
Rotzinger et al., Life Sci 1995 : The nitric oxide synthase inhibitor NW-nitro-L-arginine methylester attenuates brain catalase activity in vitro