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ARG2 — NOS2

Text-mined interactions from Literome

Baggio et al., J Pharmacol Exp Ther 1999 : We conclude that arginase plays a significant role in the regulation of nitric oxide synthase mediated NANC relaxation in the IAS
Munder et al., J Immunol 1999 : The balance between the two enzymes is competitively regulated by Th1 and Th2 T helper cells via their secreted cytokines : Th1 cells induce iNOS , whereas Th2 cells induce arginase
Agawa et al., Virology 2002 : These results indicated that L-Arg induces iNOS and generates NO, which inhibits EBV reactivation in EBV positive cells
Schneider et al., Kidney Int 2003 (Acute Kidney Injury...) : l-Arg had a beneficial effect on GFR and RPF, decreased O2- production, diminished up-regulation of soluble guanylate cyclase, and prevented up-regulation of iNOS
Gobert et al., J Immunol 2004 (Colitis...) : Arginase I, iNOS , and ODC were induced in the colon during the infection, while arginase II was not up-regulated
Sasaki et al., Am J Physiol Lung Cell Mol Physiol 2007 (Hypertension, Pulmonary...) : Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats
Sahach et al., FiziolohichnyÄ­ zhurnal (Kiev, Ukraine : 1994) 2007 : The studies also two NO synthase (NOS) isoform activity -- inducible ( iNOS ) and constitutive ( cNOS ), activity of arginase and nitrate reductase and the content of high-molecular nitrosothiols ( HMNT ) and low-molecular nitrosothiols ( LMNT ) and stable metabolites of NO ( NO ( - ) 2, NO ( - ) 3 )
Kim et al., J Appl Physiol 2009 : These data indicate that iNOS dependent S-nitrosylation of arginase 1 and the increase in arginase activity lead to eNOS uncoupling, contributing to the nitroso-redox imbalance, endothelial dysfunction, and vascular stiffness observed in vascular aging
Bratt et al., Toxicol Appl Pharmacol 2010 (Pneumonia...) : NOS2-/- mice had significantly greater arginase1 and arginase2 concentrations compared to their respective C57BL/6 groups, indicating that inhibition of arginase may be dependent upon NOS2 expression
Lee et al., Mol Cells 2013 : LPS induced iNOS expression and poly ADP-ribose polymerase cleavage were significantly suppressed by arginase II overexpression
Thiemermann et al., Proc Natl Acad Sci U S A 1993 (Shock, Hemorrhagic) : This hyporeactivity is mediated by an enhanced release of NO by the constitutive NOS, for it was reversed by NG-nitro-L-arginine methyl ester ( NO2Arg ), an inhibitor of both constitutive and inducible NOS , but it was not prevented by dexamethasone, an inhibitor of NOS induction
Hrabák et al., Life Sci 1997 : The weak inhibitory effect of non-arginine based iNOS inhibitors on arginase activity further supports the view that such compounds may be of practical use for inhibition of NO production in cells simultaneously expressing iNOS and arginase
Munder et al., J Immunol 1998 : We have previously shown that CD4+ T cell derived cytokines regulate a competitive balance in the expression of both enzymes in macrophages ; Thl-type cytokines induce iNOS while they inhibit arginase , whereas the reverse is the case for Th2-type cytokines