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BCR — PLCG1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
BCR
→
PLCG1
(reaction)
Carpenter et al., Exp Cell Res 1999, Guasch et al., Mol Cell Biol 2001, Roumiantsev et al., Cancer Cell 2004, Chase et al., Blood 2007, Lelièvre et al., Molecular cancer 2008
-
Reactome Reaction:
BCR
→
PLCG1
(indirect_complex)
Guasch et al., Mol Cell Biol 2001, Roumiantsev et al., Cancer Cell 2004, Chase et al., Blood 2007, Lelièvre et al., Molecular cancer 2008
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
DeBell et al., Mol Cell Biol 1999
:
B-cell receptor (BCR) induced activation of
phospholipase C-gamma1 ( PLCgamma1 ) and PLCgamma2 is crucial for B-cell function ... The role of PLCgamma1 SH2 and SH3 domains at different steps of
BCR induced
PLCgamma1 activation was examined by reconstitution in a PLCgamma negative B-cell line ... PLCgamma1 SH domains, therefore, have interrelated but distinct roles in
BCR induced
PLCgamma1 activation
Che et al., Circulation 2001
:
Because phosphatidylinositol 3'-kinase (PI3-K) is essential for Bcr/Abl leukemogenesis, we evaluated the
role of mouse PDGF-beta-receptor binding sites for PI3-K ( Y708, Y719 ) and for
phospholipase C-gamma ( Y977, Y989 ) in PDGF mediated
Bcr kinase activation
Venkataraman et al., Mol Immunol 1998
:
Previous studies have shown that PKA-activation blocks
BCR induced
phospholipase Cgamma-activation and calcium mobilization