◀ Back to EPHB2
BCL2 — EPHB2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Srivastava et al., Proc Natl Acad Sci U S A 1999
(Breast Neoplasms) :
Paclitaxel induced apoptosis was associated with phosphorylation of
Bcl-2 and
activation of
ERK and JNK MAPKs ... By contrast, neither an
ERK inhibitor ( PD098059 ) nor p38 inhibitors ( SB203580 and SB202190 )
had an effect on
Bcl-2 phosphorylation
Huang et al., Oncogene 1999
:
Taxol induced apoptosis was associated with phosphorylation of both c-Raf-1 and
Bcl-2 and
activation of
ERK and JNK MAP kinases
Boucher et al., J Cell Biochem 2000
(Carcinoma...) :
Herein, we showed that inhibition of
ERK1/2 activities
caused ( 1 ) a G1 arrest ; ( 2 ) a down-regulation of the expression levels of the anti-apoptotic homologs
Bcl-2 , Mcl-1, and Bcl-X ( L ) without affecting the pro-apoptotic levels of Bax and Bak ; ( 3 ) a promotion of caspases 3, 6, 8, and 9 activities ; ( 4 ) a stimulation of PARP cleavage ; and ( 5 ) a programmed cell death by apoptosis
McKean et al., J Immunol 2001
(MAP Kinase Signaling System) :
Importantly, when TCR activated thymocytes are simultaneously coengaged by both CD28 and CD2 receptors, CD28 signals can inhibit
ERK/MAPK dependent
Bcl-2 protein up-regulation
Song et al., Zhonghua Xue Ye Xue Za Zhi 2002
(Multiple Myeloma) :
In addition, the expression of gp130 on cell surface, the
activation of protein kinase
ERK and the expression of
Bcl-2 and Bcl-x ( L ) were all down regualted in IFNalpha stimulated Sko-007 cells
Azuma et al., Anticancer Res 2003
(Mammary Neoplasms, Experimental) :
Selective cancer cell apoptosis induced by FTY720 ; evidence for a
Bcl dependent pathway and impairment in
ERK activity
Nishikawa et al., Int J Oncol 2003
(MAP Kinase Signaling System...) :
Western blot analysis indicated that TAC3 had both strong expression of
Bcl-2 and detachment induced
activation of extracellular signal regulated kinase (
ERK ), and it was suggested that the detachment induced proliferation signal would join the mitogen activated protein kinase ( MAPK ) cascade at the level of MAPK/ERK kinase (MEK)
Xiao et al., Oncogene 2004
(Prostatic Neoplasms) :
DATS induced
Bcl-2 phosphorylation and apoptosis were partially
attenuated by pharmacological inhibition of
ERK1/2 using PD98059 or U0126
Tamura et al., FEBS Lett 2004
(Carcinoma, Hepatocellular...) :
The phosphorylation status and anti-apoptotic activity of
Bcl-2 are
regulated by
ERK and protein phosphatase 2A on the mitochondria
Feng et al., Oncogene 2004
(MAP Kinase Signaling System) :
Furthermore, we present evidence to show that
Bcl-2 can also
activate both
ERK1 and ERK2 MAP kinases
Choi et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
Using the selective mitogen activated protein kinase kinase inhibitor PD98059, we found that Nef induced
Erk signaling is
essential for
Bcl-XL up-regulation and cell survival ... These data suggest that Nef produces survival signals in myeloid cells through
Erk mediated
Bcl-XL induction, a pathway distinct from Nef survival pathways recently reported in T lymphocytes
Ríos-Muñoz et al., J Neurochem 2005
(MAP Kinase Signaling System...) :
FGF-2 treatment caused an
ERK dependent increase in
Bcl-2 and an ERK independent increase in Bcl-x ( L )
Kataoka et al., J Gastroenterol 2005
:
The inhibition of
ERK phosphorylation by a specific inhibitor, PD98059, did not
affect the increase in
Bcl-xL expression level
Weiderhold et al., Int J Cancer 2006
(Mammary Neoplasms, Animal) :
Bcl-2 phosphorylation and
activation of
ERK and JNK and caspase 3-dependent cleavage of PARP were observed in MDA-MB-435 cells treated with CB694
Almeida et al., J Biol Chem 2005
:
Wnt3a increased the expression of the anti-apoptotic protein
Bcl-2 in an
ERK dependent manner
Wang et al., Cell Death Differ 2006
:
Cyclin dependent kinase-5 prevents neuronal apoptosis through
ERK mediated upregulation of
Bcl-2 ... This study suggests that
ERK mediated
Bcl-2 upregulation contributes to BDNF induced Cdk5 mediated neuronal survival
Nakamura et al., J Biol Chem 2006
(MAP Kinase Signaling System) :
We found that
MNSFbeta.Bcl-G directly bound to ERKs and
inhibited ERK activation by MEK1
Gary-Gouy et al., Biochem Biophys Res Commun 2006
:
Cyclosporin-A
inhibits ERK phosphorylation in B cells by modulating the binding of Raf protein to
Bcl2
Zuo et al., Eur J Pharmacol 2006
(Hypoxia-Ischemia, Brain...) :
The increased expression of Egr-1 and
Bcl-2 by isoflurane was
inhibited by
ERK inhibition
Marzec et al., Oncogene 2007
(MAP Kinase Signaling System) :
The U0126 mediated inhibition of
ERK1/2 activation
impaired proliferation and viability of the ALK+ TCL cells and expression of antiapoptotic factor
Bcl-xL and cell cycle promoting CDK4 and phospho-RB
Luo et al., Cornea 2007
(MAP Kinase Signaling System) :
The 90 mM NaCl high saline medium notably increased release of cytochrome c and Smac/DIABLO from mitochondria ; activated caspase-3, JNK and
ERK ;
stimulated mRNA expression of interleukin-1 converting enzyme and Bax ; and reduced
Bcl2 expression
Haddad et al., Protein Pept Lett 2007
(Hypoxia-Ischemia, Brain...) :
The
role of
Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion dependent regulation of MAPK (
ERK ) : discordant proteomic effect of MAPK ( p38 )
Lim et al., J Neurosci Res 2008
:
Thus, MAPK/ERK dependent p35 up-regulation and
MAPK/ERK dependent and PI3K/Akt dependent
Bcl2 up-regulation contribute to BDNF stimulated neural differentiation and to the survival of differentiated cells
Kim et al., Eur J Pharmacol 2008
:
We also found that propofol treatment enhanced expression of anti-apoptotic protein
Bcl-2 and
activation of
ERK concerned with survival
Ivanov et al., Clin Cancer Res 2008
(MAP Kinase Signaling System...) :
Furthermore, we found that this increased death was associated with
ERK1/2 nuclear accumulation after tositumomab treatment, which was
enhanced in combination with RT. Importantly, although
Bcl-2 overexpression resulted in resistance to RT-induced apoptosis, it had no effect on the tumor cell death induced by tositumomab plus RT, indicating a nonapoptotic form of cell death
Creson et al., J Mol Neurosci 2009
(MAP Kinase Signaling System...) :
Evidence for
involvement of
ERK , PI3K, and RSK in induction of
Bcl-2 by valproate
Galante et al., J Surg Res 2009
(Carcinoma...) :
Finally, the
effect of the
ERK inhibitor ( PD98059 ) on
BCL-2 expression and induction of anoikis was examined ... Inhibition of
ERK down-regulated
BCL-2 and was associated with restoration of sensitivity to anoikis
Wang et al., Cancer Res 2009
(Breast Neoplasms) :
We conclude that CTGF expression could confer resistance to chemotherapeutic agents through augmenting a survival pathway through
ERK1/2 dependent
Bcl-xL/cIAP1 up-regulation
Kim et al., Yonsei Med J 2010
:
In addition, both enhancement of anti-apoptotic protein
Bcl-2 and
activation of
Erk concerned with survival were shown
Wang et al., Cancer Lett 2010
(Ovarian Neoplasms) :
Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2,
Bcl-xL and XIAP ), as well as
activation of
Ras/MEK/ERK and PI3K/Akt signaling ... Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins (
Bcl-2 , Bcl-xL and XIAP ), as well as
activation of
Ras/MEK/ERK and PI3K/Akt signaling
Gupta et al., Int J Oncol 2011
(Cerebellar Neoplasms...) :
Intermittent hypoxia also inhibited expression of pro-anti-apoptotic proteins ( Bax and Bad ), and induced expression of anti-pro-apoptotic proteins ( Bcl2 and
Bcl-xL ), and
activation of
ERK in medulloblastoma cells
Qiao et al., World J Gastroenterol 2011
(Reperfusion Injury) :
On the other hand, inhibition of activation of
ERK1/2 induced by PD98059, a specific upstream MEK inhibitor,
had significant effects on
Bcl-2 and Bax in GI-R
Liu et al., J Pharmacol Sci 2012
(Lung Neoplasms) :
Moreover,
ERK activation upregulated Beclin-1 expression through induction of Bcl-2 phosphorylation, but p53 did not
induce Bcl-2 phosphorylation ... In conclusion, inhibition of c-Met induced autophagic cell death, which was associated with ERK-p53 activation and
ERK mediated
Bcl-2 phosphorylation in A549 cells
Sale et al., Br J Pharmacol 2013
(MAP Kinase Signaling System...) :
Indeed, although inhibition of
ERK1/2 invariably
increases the expression of pro-apoptotic
BCL2 family proteins, tumour cells undergo minimal apoptosis
Liu et al., Br J Pharmacol 2013
:
The dual function of MAPK/ERK pathway in defining BH3 mimetics was illustrated
; ERK1/2 activation
leaded to
Bcl-2 transcriptional up-regulation and sustained phosphorylation in naïve and acquired resistant SCLC cells
Wang et al., J Chemother 2013
(Carcinoma, Non-Small-Cell Lung...) :
These data indicate that the cooperative effects of
p-ERK1/2 and p-Akt on attenuating cisplatin cytotoxicity are
mediated by PUMA and
Bcl-2 regulation, and concurrently blocking these pathways may be an effective strategy for improving the efficacy of cisplatin as anticancer treatment