Gene interactions and pathways from curated databases and text-mining

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EDNRB — MAPK14

Pathways - manually collected, often from reviews:

  • NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → p38 alpha (MAPK14) (modification, activates) Aquilla et al., J Biol Chem 1996
    Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Hersch et al., Am J Physiol Cell Physiol 2004 : PP2A was activated via a pathway involving ETB dependent stimulation of p38 MAPK activity
Nilsson et al., BMC cardiovascular disorders 2008 : We hypothesize that mitogen activated kinases ( MAPK ) and protein kinase C ( PKC ) are involved in the regulation of endothelin ETB receptors in human internal mammary arteries