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GRAP2 — HMOX1
Text-mined interactions from Literome
Lee et al., Circulation 2004
:
Simvastatin activated p38 and Akt in VSMCs, and the respective inhibitors of p38 and phosphoinositide 3-kinase (PI3K) greatly reduced the level of simvastatin induced HO-1, which suggests the
involvement of
p38 and the PI3K-Akt pathway in
HO-1 induction
Wijayanti et al., Antioxid Redox Signal 2004
(MAP Kinase Signaling System) :
Moreover, the p38 mitogen activated protein kinase ( MAPK ) inhibitor SB203580 and overexpressed dominant negative p38beta decreased, whereas dominant negative
p38delta increased , LPS dependent induction of
HO-1 gene expression
Lamore et al., J Photochem Photobiol B 2010
:
DHP-lysine photosensitization induced intracellular oxidative stress,
p38 MAPkinase
activation , and upregulation of
heme oxygenase-1 expression
Seidel et al., Respir Res 2010
(Airway Remodeling) :
HO-1 expression was reversed by GSH-OEt, or
p38 MAPK
inhibition , or
HO-1 siRNA, which all reversed the anti-proliferative effect of DMF
Kästle et al., Free Radic Biol Med 2012
(MAP Kinase Signaling System) :
Histone deacetylase 6 (HDAC6) plays a crucial role in
p38MAPK dependent
induction of
heme oxygenase-1 (HO-1) in response to proteasome inhibition