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IL7 — JAK3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Barata et al., Blood 2004
(Disease Progression...) :
Stimulation of TAIL7 cells by
IL-7 leads to phosphorylation of
Janus kinase 3 (JAK3) , signal transducer and activator of transcription 5 ( STAT5 ), Akt/PKB ( protein kinase B ), and extracellular regulated kinase 1 and 2 ( Erk1/2 ) ... Importantly, specific blockade of JAK3 by its inhibitor WHI-P131 abrogates the IL-7 mediated proliferation and survival of TAIL7 cells, suggesting that activation of
JAK3 is
critical for
IL-7 responsiveness by these cells
Fleming et al., J Immunol 2004
:
Cell lines derived from CD45-deficient animals experience prolonged
JAK/STAT activation in
response to
IL-7 stimulation, and constitutively elevated levels of phosphorylated src kinases
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Barata et al., Leukemia & lymphoma 2005
(Leukemia-Lymphoma, Adult T-Cell) :
IL-7 induces the activation of
Jak/STAT , MEK/Erk and PI3K/Akt signaling pathways in T-ALL cells
Jahn et al., Blood 2007
:
Kit activated
Jak3 in an
IL-7R dependent manner
Tamarit et al., J Biol Chem 2013
:
We show that lipid raft inhibitors delay and reduce
IL-7 induced JAK1 and
JAK3 phosphorylation
Foxwell et al., Eur J Immunol 1995
:
Interleukin-7 can
induce the activation of Jak 1,
Jak 3 and STAT 5 proteins in murine T cells
Tortolani et al., J Immunol 1995
(Leukemia) :
In addition, IL-4 and
IL-7 induced the rapid tyrosine phosphorylation of JAK3 and JAK1, and IL-4
activated both
JAK3 and JAK1 phosphotransferase activity
Sharfe et al., Blood 1995
:
Specific inhibition of
IL-7 induced
Jak kinase activity ablates p85 tyrosine phosphorylation, subsequent P13 kinase activation, and, ultimately, proliferation
Russell et al., Science 1994
(Severe Combined Immunodeficiency) :
IL-2, IL-4,
IL-7 ( whose receptors are known to contain gamma c ), and IL-9 ( whose receptor is shown here to contain gamma c )
induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases Jak1 and
Jak3