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PLAT — TNF

Text-mined interactions from Literome

Chia et al., Arterioscler Thromb Vasc Biol 2003 (Vasculitis) : Intra-arterial tumor necrosis factor-alpha impairs endothelium dependent vasodilatation and stimulates local tissue plasminogen activator release in humans
Gingras et al., Biochem Biophys Res Commun 2004 : RT-PCR analysis and gene reporter assays using the human tPA promoter indicated that upregulation of the tPA gene transcription by both Neovastat and TNFalpha was correlated with the phosphorylation of JNK1/2 and of IkappaB and that SP600125 and BAY11-7082, inhibitors of JNK and IkappaK, respectively, inhibit the increase of tPA gene transcription induced by Neovastat and TNFalpha
Aderka et al., Isr J Med Sci 1991 (Disseminated Intravascular Coagulation...) : At the endothelial level TNF down-regulates thrombomodulin ( thus preventing protein C formation ) and inhibits the production of tissue plasminogen activator (t-PA) , thus impairing anticoagulant mechanisms
Haile et al., J Cereb Blood Flow Metab 2012 (Hypoxia-Ischemia, Brain) : We present in vitro and in vivo evidence indicating that endogenous tPA and recombinant tPA induce the expression of neuronal tumor necrosis factor-a
Pineda et al., Glia 2012 (MAP Kinase Signaling System) : Here, we found that tPA is required for Aß-mediated microglial inflammatory response and tumor necrosis factor-a release
Trân-Thang et al., Br J Cancer 1996 (Colonic Neoplasms) : Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator ( uPA ), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 ( PAI-1 ) as analysed by zymography, enzyme immunoassays and Northern analysis