◀ Back to TNF

PHEX — TNF

Text-mined interactions from Literome

Uno et al., Gastroenterology 2006 (Colitis...) : The aim of this study was to evaluate whether TNF-alpha regulates Phex gene expression thus contributing to the abnormal bone metabolism observed in IBD
Majewski et al., J Biol Chem 2010 (Colitis...) : Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 ( PARP-1 ) in the TNF induced inhibition of PHEX expression in osteoblasts ... The aim of this study was to determine the molecular mechanism involved in TNF mediated down-regulation of Phex gene transcription ... We identified poly(ADP-ribose) polymerase 1 ( PARP-1 ) binding immediately upstream of the NF-?B sites and showed that TNF induced poly ( ADP-ribosyl ) ation of RelA when bound to the Phex promoter ... TNF mediated Phex down-regulation was completely abrogated in vitro by PARP-1 inhibitor and overexpression of poly ( ADP-ribose ) glucohydrolase ( PARG ) and in vivo in PARP-1 ( -/- ) mice