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ODC1 — TNF

Text-mined interactions from Literome

Satriano et al., Am J Physiol 1999 : TNF-alpha and IFN-gamma induction of NO generation resulted in suppressed ODC activity, an effect prevented by the inducible NOS inhibitor L-N6- ( 1-iminoethyl ) lysine ( L-NIL )
Endo et al., Immunol Lett 1992 : IL-1 alpha, IL-1 beta, TNF alpha and TNF beta induced HDC and ODC , as does LPS
Endo et al., Br J Pharmacol 1992 (Drug-Induced Liver Injury) : 2. The induction of ODC by LPS, IL-1 or TNF was suppressed by GalN in the liver, and this suppression preceded the hepatic congestion
Chung et al., Surgery 1992 : The purpose of this study was to determine whether interleukin-1 (IL-1) or tumor necrosis factor (TNF) , which are released immediately after injury, regulates gut mucosal ODC enzyme activity and gene expression ... IL-1, but not TNF , increased small intestinal ODC enzyme activity ... Both IL-1 and TNF increased small intestinal ODC mRNA levels
Liao et al., Leuk Res 2008 : Meanwhile conventional expression of ODC represses tumor necrosis factor-alpha (TNF-alpha) expression and nuclear factor-kappaB (NF-kappaB) activation as well as MMP-9 enzyme activity
Liao et al., Life Sci 2008 : In our previous studies, ornithine decarboxylase (ODC) overexpression prevented tumor necrosis factor alpha (TNF-alpha)- and methotrexate induced apoptosis via reduction of ROS
Donato et al., J Cell Biochem 1991 : TNF induced cytotoxicity in ME-180 cervical carcinoma cells and, interestingly, stimulated both ODC activity ( 3-6-fold ) and putrescine accumulation when measured prior to the onset of cytotoxicity ... Induction of ODC was TNF concentration dependent and paralleled the concentration-dependency for cytotoxicity ... Based upon studies with cycloheximide, de novo protein biosynthesis was required for TNF mediated ODC induction in ME-180 cells ... Interferon gamma treatment had no significant effect on basal ODC activity but inhibited TNF mediated ODC induction by approximately 50 %
D'Souza et al., J Neuroimmunol 1994 : When used individually, however, only IL-1 alpha ( 79 +/- 3 % ), IFN-gamma ( 70 +/- 2 % ) and TNF-alpha ( 65 +/- 5 % ) induced ODC hsp72 expression in mixed glial cell cultures
Penning et al., Cytokine 1998 : In PC60 R55/R75 cells, TNF induced ODC activity was completely suppressed by externally added spermine ( Spm )