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CCL17 — TNF
Text-mined interactions from Literome
Ju et al., Biochem Biophys Res Commun 2009
:
Keratinocytes, one of major cell types in the skin, can be
induced by
TNF-alpha and IFN-gamma to express thymus- and activation regulated chemokine (
TARC/CCL17 ), which is considered to be a pivotal mediator in the inflammatory responses during the development of inflammatory skin diseases, such as atopic dermatitis ( AD )
Choi et al., Arch Pharm Res 2010
:
Interestingly, PC significantly suppressed IFN-gamma and
TNF-alpha induced
TARC/CCL17 , MDC/CCL22 and CTACK/CCL27 expression via the induction of heme oxygenase (HO)-1 ... Furthermore, exogenous CO, but not other end products of HO-1 activity, also suppressed IFN-gamma and
TNF-alpha induced
TARC/CCL17 , MDC/CCL22 and CTACK/CCL27 expression
Shibata et al., Vet Immunol Immunopathol 2011
:
Identification of the signaling pathway of
TNF-a induced
CCL17/TARC transcription in a canine keratinocyte cell line ... The aim of the present study is to clarify the regulatory mechanism of
TNF-a induced
CCL17 mRNA transcription in canine keratinocytes leading to the development of a chemokine targeted therapy for cAD ... The present results suggest that
TNF-a induced
CCL17 mRNA transcription in CPEK is positively regulated by p38 but negatively controlled by ERK
Jung et al., Biochem Biophys Res Commun 2012
(Dermatitis, Atopic) :
In present study, we investigated the effect of spinasterol-Glc on production of
TARC/CCL17 induced by
TNF-a and IFN-? in human HaCaT keratinocytes ... Spinasterol-Glc inhibited the mRNA and protein expression of
TARC/CCL17 induced by
TNF-a/IFN-? in a dose dependent manner ... Inhibitors of c-Raf-1, p38 MAPK, and JAK2, suppressed the
TNF-a/IFN-? induced production of
TARC/CCL17 , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc