Gene interactions and pathways from curated databases and text-mining

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EGF — MVP

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MVP → EGF (increases) Kim et al., FEBS J 2006*
    Evidence: We found that the interaction between Src and MVP is critically dependent on Src activity and protein (MVP) tyrosyl phosphorylation, which are induced by EGF stimulation.

Text-mined interactions from Literome

Kolli et al., J Biol Chem 2004 : MVP also interacts with the activated form of the extracellular regulated kinases ( Erks ) in response to EGF and a constitutive complex between tyrosyl phosphorylated MVP, SHP-2, and the Erks was detected in MCF-7 breast cancer cells
Kim et al., FEBS J 2006 : A subcellular localization study using immunofluorescence microscopy shows that epidermal growth factor (EGF) stimulation triggers MVP translocation from the nucleus to the cytosol and perinuclear region where it colocalizes with Src ... We found that the interaction between Src and MVP is critically dependent on Src activity and protein ( MVP ) tyrosyl phosphorylation, which are induced by EGF stimulation