Rival et al., Eur J Pharmacol 2002
:
PPARalpha and PPARdelta activators inhibit cytokine induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells
Kurebayashi et al., Atherosclerosis 2005
(Insulin Resistance) :
The considered PPARdelta activator GW501516 and the considered PPARalpha activator fenofibrate also inhibited TNF-alpha induced VCAM-1 expression, whereas pioglitazone and rosiglitazone did not
Fan et al., Arterioscler Thromb Vasc Biol 2008
(Inflammation) :
In human umbilical vein endothelial cells ( HUVECs ), the synthetic PPAR-delta ligands GW0742 and GW501516 significantly inhibited tumor necrosis factor (TNF)-alpha induced expression of vascular cell adhesion molecule-1 and E-selectin ( assayed by real-time RT-PCR and Northern blotting ), as well as the ensuing endothelial-leukocyte adhesion