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EGF — STAT3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Guren et al., Biochem Biophys Res Commun 1999
:
EGF induced activation of Stat1,
Stat3 , and Stat5b is unrelated to the stimulation of DNA synthesis in cultured hepatocytes ... In freshly isolated hepatocytes,
EGF activated Stat1,
Stat3 , and, particularly, Stat5b ... In these cells
EGF did not detectably
activate Stat1,
Stat3 , or Stat5b but markedly stimulated MAP kinase ( Erk1/2 )
Lim et al., J Biol Chem 1999
:
Correspondingly, pretreatment of cells with UV reduced the
EGF stimulated tyrosine phosphorylation and phosphotyrosine dependent activities of
Stat3
Rebsamen et al., J Mol Cell Cardiol 2000
(Cardiomegaly) :
EGF did not
activate Stat1 and
Stat3 , but did induce a rapid and transient activation of Stat5, which corresponded mainly to Stat5b DNA binding
Cheng et al., Proc Natl Acad Sci U S A 2001
:
The related cytokines Il-6, ciliary neurotrophic factor, as well as
epidermal growth factor , do not
activate Stat3 , although epidermal growth factor stimulates mitogen activated protein kinase
Niu et al., Oncogene 2002
(Melanoma) :
Blocking Src tyrosine kinase activity, but not
EGF receptor or JAK family kinases,
leads to inhibition of
Stat3 signaling in melanoma cell lines
Real et al., Oncogene 2002
(Brain Neoplasms...) :
In the brain subline, both expression of Bcl-2 and
Stat3 activation were
induced by
epidermal growth factor and abrogated after treatment with kinase inhibitors specific for epidermal growth factor receptor or Jak2
Krause et al., J Immunol 2002
(Arthritis, Rheumatoid) :
Stat3-YF also induced apoptosis in osteoarthritis synoviocytes, and levels of apoptosis were
increased by exogenous
EGF
Song et al., Oncogene 2003
(Carcinoma, Non-Small-Cell Lung...) :
Furthermore, the
stimulation of
Stat3 DNA binding activity by
EGF requires the activity of EGF-R tyrosine kinase as well as Src-kinase, while the upregulation of Stat3 activity by IL-6 or HGF requires only Src-kinase activity
Buerger et al., J Biol Chem 2003
:
EGF induced phosphorylation of
Stat3 at tyrosine 705 and Stat3 dependent transactivation were also impaired ... Transduction of a short synthetic peptide aptamer sequence not embedded into the scaffold protein resulted in the same impairment of
EGF induced
Stat3 activation
Zhang et al., Biochem J 2003
:
In the present study, we report that transient expression of Grb2 specifically down-regulates
EGF stimulated tyrosine phosphorylation of
Stat3 , which leads to a repression of Stat3 transcriptional activity ... In contrast, depletion of Grb2 by RNA interference substantially increases
Stat3 tyrosine phosphorylation
induced by
EGF
Burova et al., Tsitologiia 2003
:
[STAT1 and
STAT3 activation by oxidative stress in A431 cells
involves Src dependent
EGF receptor transactivation ]
Sato et al., Genes Cells 2003
:
Phosphorylation of
Stat 3/5 in
response to p52shc expression,
EGF or H2O2 could also be inhibited by introduction into cells of phospho-Tyr 845-specific antibody or by expression of dominant negative version of c-Src
Shi et al., J Biol Chem 2004
:
Expression of constructs for dominant negative forms of either Pyk2 or c-Src impair
EGF induced
Stat3 phosphorylation
Dowlati et al., Mol Cancer Ther 2004
:
However, inhibition of EGFR by AG1478 fails to decrease
EGF induced
Stat-3 phosphorylation ... Our study suggests that residual ErbB2 activation by
EGF , despite EGFR blockade, is
responsible for persistent downstream activation of
Stat-3
Quadros et al., Cancer Res 2004
(Carcinoma, Squamous Cell...) :
Specifically, constitutive and
epidermal growth factor induced phosphorylation of
STAT3 on Y705 was observed only in SCC but not in either immortalized ( HaCaT ) or normal keratinocyte strains
Vasilenko et al., Tsitologiia 2004
:
Here, we have compared STAT1 and
STAT3 activation in
response to IFNgamma, IFNalpha and
epidermal growth factor (EGF) in A431 cells ... We have shown the STAT1 activation by all these agents ; unlike,
STAT3 was
activated by
EGF only
Zhang et al., Exp Eye Res 2005
:
Retinas from embryonic and neonatal stages showed that
STAT3 but not STAT1 was activated in
response to ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), fibroblast growth factor-1 (FGF1), fibroblast growth factor-2 (FGF2),
epidermal growth factor (EGF) , interferon-alpha ( IFN-alpha ) and interferon-gamma (IFN-gamma) in distinct patterns
Scoles et al., Biochem Biophys Res Commun 2005
(Neurilemmoma) :
We demonstrated that HRS expression reduced EGFR abundance and
EGF mediated
Stat3 activation ... Schwannomin inhibited
EGF mediated
Stat3 activation, consistent with HRS and schwannomin interacting in the same signaling pathway
Itoh et al., Oncogene 2006
(Urinary Bladder Neoplasms) :
We report that
STAT3 , but not STAT1 and STAT5, becomes phosphorylated in
response to
epidermal growth factor (EGF) and achieves maximal induction of collagenase-1 ( MMP-1 ) transcription by interacting with c-JUN
Walters et al., Am J Pathol 2005
(Disease Models, Animal...) :
However,
Stat3 phosphorylation
induced by PDGF,
EGF , or IFN-gamma increased twofold in Stat1-/- fibroblasts compared to wild-type fibroblasts ... Our findings indicate that Stat1-/- mice are more susceptible to bleomycin induced lung fibrosis than wild-type mice due to 1 ) enhanced fibroblast proliferation in response to growth factors (
EGF and PDGF ), 2 ) stimulation of fibroblast growth by a Stat1 independent IFN-gamma signaling pathway, and 3 ) increased
activation of
Stat3
Zhou et al., Br J Cancer 2006
(Disease Progression...) :
STAT3 is
required but not sufficient for
EGF receptor mediated migration and invasion of human prostate carcinoma cell lines
Akca et al., Lung Cancer 2006
(Adenocarcinoma...) :
EGF induced phosphorylation of EGFR, AKT, p44/42 MAPK and
STAT3 to various extents, but the level of induction was not associated with the existence of EGFR mutation
Aaronson et al., Mol Cell Endocrinol 2007
(Prostatic Neoplasms) :
Increasing the protein levels of the signal transducer and activator of transcription 3 ( Stat3 ) led to
Stat3-androgen receptor (AR) complex formation in
response to
epidermal growth factor (EGF) and interleukin-6 (IL-6) stimulation
Lo et al., Cancer Res 2007
(Breast Neoplasms...) :
Chromatin immunoprecipitation assays further show that
EGF induces binding of nuclear
STAT3 to the TWIST promoter
Seki et al., J Hepatol 2008
:
Since HGF and
EGF can
activate STAT3 via gp130 independent MET and EGFR, respectively, we assumed that these factors account for STAT3 dependent liver regeneration
Chau et al., Biochem Biophys Res Commun 2008
(Prostatic Neoplasms) :
As expected,
EGF and IL-6
increased STAT3 reporter activity and enhanced the nuclear localization of phosphorylated STAT3 ( pSTAT3 ) ; whereas Cucurbitacin I and AG490 decreased STAT3 reporter activity dose and time-dependently and reduced the localization of pSTAT3 in the nuclei of prostate cancer cells
Kim et al., Cell Signal 2009
(Breast Neoplasms) :
EGF also
induced the phosphorylation of EGFR, ERK, and
STAT-3 , and these effects were inhibited by the EGFR inhibitor, AG1478.To investigate the involvement of the STAT-3 pathway on EGF induced MMP-9 expression, we pretreatedSKBR3 cells with JAK1, JAK2, and JAK3 inhibitors prior to EGF treatment ... In addition,
EGF induced
STAT-3 phosphorylation was only inhibited by WHI-P131 ... Therefore, for the first time, we suggest that the JAK3 inhibitor, WHI-P131, inhibits
EGF induced
STAT-3 phosphorylation as well as ERK phosphorylation
Ma et al., Invest New Drugs 2010
(Nasopharyngeal Neoplasms...) :
Gefitinib at IC ( 50 ) concentrations significantly suppressed
EGF induced activation of p-EGFR, phospho-mitogen activated protein kinase ( p-MAPK ) and
p-STAT3 , but p-AKT showed persistent activation in HK1 and HONE-1 cells
González et al., J Endocrinol 2010
:
Consequently,
EGF induced phosphorylation of EGFR, AKT, ERK1/2,
STAT3 , and STAT5 was significantly decreased in these mice ... However, EGF stimulation caused similar levels of EGFR, AKT, and ERK1/2 phosphorylation in normal and transgenic mice, while
EGF induction of
STAT3 and STAT5 phosphorylation was inhibited in the transgenic mice
Yuan et al., J Biol Chem 2010
(Breast Neoplasms...) :
Furthermore, PTPN9 WT expression specifically impairs
EGF induced
STAT3 and STAT5 activation, and inhibits the cell growth in soft agar
Liu et al., Oncogene 2010
(Cell Transformation, Neoplastic) :
Remarkably, through activation of Src,
EGF increased the formation of Eps8/IRSp53 complex and
Stat3 activation in HeLa cells
Chen et al., Mol Cell Biochem 2011
:
These results are the first evidence that
EGF induces proliferation of rat spermatogonial stem cells through
c-Src/STAT3 signal
Gierut et al., Gastroenterology 2011
(Aberrant Crypt Foci...) :
Stable knockdown of PTK6 reduced basal levels of active
STAT3 , as well as
activation of STAT3 by
epidermal growth factor in HCT116 cells
Klein et al., Head Neck 2012
(Carcinoma, Squamous Cell...) :
Additionally, vandetanib abrogates
EGF induced
STAT3 activity and STAT3 target gene expression
Luwor et al., Growth Factors 2012
:
Dynamin II function is required for
EGF mediated
Stat3 activation but not Erk1/2 phosphorylation
Tervaniemi et al., PloS one 2012
(Psoriasis) :
CCHCR1 also regulates
EGF induced
STAT3 activation in an isoform-specific manner : the tyrosine phosphorylation of STAT3 is disturbed in isoform 3-transfected cells
Chen et al., Gynecol Oncol 2013
(Disease Models, Animal...) :
We found that MUC20 overexpression could enhance
EGF induced phosphorylation of EGFR and
STAT3
Cao et al., Mol Cell Biol 1996
:
Among them,
Stat3 has 52.5 % amino acid sequence homology with Stat1 and is
activated by platelet derived growth factor ( PDGF ), colony stimulating factor 1 (CSF-1),
EGF , interleukin-6, and other cytokines
Zou et al., J Biol Chem 1997
:
EGF dependent phosphorylation of E12R2, JAK2, Tyk2, and
STAT3 was observed
Planas et al., J Neurochem 1997
:
Stimulation of
epidermal growth factor or cytokine receptors can
cause activation of
Stat3 and transduction of specific responses to the nucleus
Faris et al., Immunology 1997
:
Moreover,
EGF treatment
induced Stat3 phosphorylation in cells transfected with the intact chimeric EGF-gp130 receptor along with induction of DNA-mobility shift of a classical interferon-gamma activated site
Xie et al., Anticancer Res 1997
(Breast Neoplasms) :
Using electrophoretic mobility shift assays ( EMSA ), we found that
EGF activates STAT1 and
STAT3 in the MDA468 cells
Garcia et al., Cell Growth Differ 1997
(Breast Neoplasms...) :
Moreover,
Stat3 is activated in
response to
epidermal growth factor (EGF) but not heregulins in immortalized normal human breast epithelial cells ... Furthermore, experiments with an EGF receptor-specific inhibitor indicated that the constitutive activation of Stat3 in these breast carcinoma cell lines is not necessarily dependent on signaling through the EGF receptor, although
EGF stimulation further
increases Stat3 activation
Iwamoto et al., J Biol Chem 1998
:
EGF activates STAT1 and
STAT3 in A431 but not in HeLa and PC12 cells