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IL6 — TNFRSF11B
Text-mined interactions from Literome
Sakata et al., J Bone Miner Res 1999
:
However,
IL-6 and transforming growth factor-beta
had little effect on
OPG/OCIF mRNA levels in HPDL
Viereck et al., J Clin Endocrinol Metab 2003
:
Raloxifene concurrently stimulates
osteoprotegerin and
inhibits interleukin-6 production by human trabecular osteoblasts ... In conclusion, our data suggest that raloxifene stimulates
OPG production and
inhibits IL-6 production by hOB
Miyashita et al., Clin Exp Immunol 2004
(Arthritis, Rheumatoid) :
Neither
IL-6 nor tumour necrosis factor (TNF)-alpha
increased the production of
OPG from FLS
Evans et al., J Bone Miner Res 2006
:
Adenosine stimulated
IL-6 but
inhibited osteoprotegerin secretion, suggesting that adenosine is a newly described regulator of progenitor cell function
Lawrie et al., Am J Pathol 2008
(Hypertension, Pulmonary) :
Additionally, both 5-HT and
interleukin-1 also
increased OPG secretion
Kallio et al., Mol Cell Endocrinol 2008
:
In addition, E2 and Osp opposed the etoposide induced increase of
IL-6 and decrease of
OPG which changes would
increase osteoclastic activity
Sanchez et al., Osteoarthritis Cartilage 2009
(Mechanotransduction, Cellular) :
IL-6 neutralizing antibodies and piroxicam
inhibited the decrease
OPG expression, but did not modify RANKL mRNA level, indicating that IL-6 and PGE ( 2 ) induce a decrease of the OPG/RANKL ratio
Katopodis et al., Anticancer Res 2009
(Bone Neoplasms...) :
The enhancement of the
OPG expression in PC-3 cells by MG-63 cells is not
mediated by IGF-1,
IL-6 and TGFbeta1
Wang et al., Mol Cell Endocrinol 2011
:
LC, a novel estrone-rhein hybrid compound, concurrently stimulates
osteoprotegerin and
inhibits receptor activator of NF-?B ligand ( RANKL ) and
interleukin-6 production by human osteoblastic cells
Lee et al., Arthritis Res Ther 2011
(Arthritis, Gouty...) :
MSU crystals induced the expressions of IL-1,
IL-6 , TNF-alpha and RANKL in PBMCs, but
inhibited OPG expression
Vidal et al., Biochem Biophys Res Commun 1998
(Bone Neoplasms...) :
Interleukin-6 (IL-6) , under similar culture conditions, does not
affect OPG mRNA levels