Gene interactions and pathways from curated databases and text-mining

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IL6 — TNFRSF11B

Text-mined interactions from Literome

Sakata et al., J Bone Miner Res 1999 : However, IL-6 and transforming growth factor-beta had little effect on OPG/OCIF mRNA levels in HPDL
Viereck et al., J Clin Endocrinol Metab 2003 : Raloxifene concurrently stimulates osteoprotegerin and inhibits interleukin-6 production by human trabecular osteoblasts ... In conclusion, our data suggest that raloxifene stimulates OPG production and inhibits IL-6 production by hOB
Miyashita et al., Clin Exp Immunol 2004 (Arthritis, Rheumatoid) : Neither IL-6 nor tumour necrosis factor (TNF)-alpha increased the production of OPG from FLS
Evans et al., J Bone Miner Res 2006 : Adenosine stimulated IL-6 but inhibited osteoprotegerin secretion, suggesting that adenosine is a newly described regulator of progenitor cell function
Lawrie et al., Am J Pathol 2008 (Hypertension, Pulmonary) : Additionally, both 5-HT and interleukin-1 also increased OPG secretion
Kallio et al., Mol Cell Endocrinol 2008 : In addition, E2 and Osp opposed the etoposide induced increase of IL-6 and decrease of OPG which changes would increase osteoclastic activity
Sanchez et al., Osteoarthritis Cartilage 2009 (Mechanotransduction, Cellular) : IL-6 neutralizing antibodies and piroxicam inhibited the decrease OPG expression, but did not modify RANKL mRNA level, indicating that IL-6 and PGE ( 2 ) induce a decrease of the OPG/RANKL ratio
Katopodis et al., Anticancer Res 2009 (Bone Neoplasms...) : The enhancement of the OPG expression in PC-3 cells by MG-63 cells is not mediated by IGF-1, IL-6 and TGFbeta1
Wang et al., Mol Cell Endocrinol 2011 : LC, a novel estrone-rhein hybrid compound, concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-?B ligand ( RANKL ) and interleukin-6 production by human osteoblastic cells
Lee et al., Arthritis Res Ther 2011 (Arthritis, Gouty...) : MSU crystals induced the expressions of IL-1, IL-6 , TNF-alpha and RANKL in PBMCs, but inhibited OPG expression
Vidal et al., Biochem Biophys Res Commun 1998 (Bone Neoplasms...) : Interleukin-6 (IL-6) , under similar culture conditions, does not affect OPG mRNA levels