Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Lienenlüke et al., Eur J Immunol 2000 : Despite enhancing expression of the other gene products, cytokines such as interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha, alone or in combination, failed to induce IL-12 p40 expression, whereas IFN-gamma markedly augmented CD154 induced IL-12 p40 and p70 release
Kopp et al., J Invest Dermatol 2001 (Disease Models, Animal...) : In contrast to interleukin-12, transgenic p40 did not stimulate interferon-gamma secretion by cultured splenocytes
van Seventer et al., J Neuroimmunol 2002 (Multiple Sclerosis) : We now describe how pre-incubation with 1000 U/ml of IFN-beta differentially regulates expression of multiple IL-12 family members in activated, immature human DC, inhibiting CD40/IFN-gamma induced p35 and p40 message levels, while enhancing p19 and Epstein-Barr virus induced gene 3 (EBI3) levels
Maruyama et al., J Immunol 2003 : The induction of the IL-12 p40 gene is regulated by NF-kappaB in the presence of IFN-gamma
Petro et al., Int Immunopharmacol 2003 : The results show that STE alone stimulates p40 and p35 promoter activity and enhances IFN-gamma induced p40 and p35 promoter activity
Zhu et al., J Biol Chem 2003 : A dominant negative NFAT molecule attenuates LPS- and IFN-gamma activated endogenous IL-12 p40 mRNA expression
Shimozato et al., Immunology 2006 (Colonic Neoplasms) : p40 did not induce interferon (IFN)-gamma or IL-17 production from splenocytes but impaired IL-23 induced cytokine production by competitive binding to the IL-23 receptors
Enríquez-de-Salamanca et al., Cytokine 2008 (Conjunctivitis, Allergic...) : TNF-alpha stimulated secretion of IL-12p40 was significantly increased by 30 min ; GM-CSF, MCP-1, IL-6, IL-7, IL-8, and RANTES were significantly increased by 2 h, and IFN-gamma and IL-1alpha by 24 h
Ma et al., J Exp Med 1996 : The priming effect of IFN-gamma on the LPS induced p40 gene transcription requires preincubation of the cells with IFN-gamma for at least 8 h to obtain a maximal effect