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IL17A — TCF25
Text-mined interactions from Literome
Schwandner et al., J Exp Med 2000
:
Although it has been well documented that
IL-17 activates the
transcription factor nuclear factor (NF)-kappaB and c-Jun NH ( 2 ) -terminal kinase ( JNK ), the upstream signaling events are largely unknown
Yu et al., J Immunol 2011
(Encephalomyelitis, Autoimmune, Experimental) :
Instead,
TCF1 regulates
IL-17 expression, in part, by binding to the regulatory regions of the Il17 gene
Ma et al., PloS one 2011
(Encephalomyelitis, Autoimmune, Experimental) :
Therefore,
TCF-1 mediates an active process to
repress IL-17 gene expression via epigenetic modifications during T cell development