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GNRH1 — SST
Text-mined interactions from Literome
Koyama et al., Endocrinology 2012
:
Somatostatin inhibition of
GnRH neuronal activity and the morphological relationship between GnRH and somatostatin neurons in rats
Offermanns et al., Eur J Biochem 1989
(Pituitary Neoplasms) :
In other pituitary cell lines,
somatostatin has been shown to cause a pertussis-toxin-sensitive decrease in adenylate cyclase activity, and
LHRH and thyrotropin releasing hormone (TRH)
stimulate phosphoinositol lipid hydrolysis in a pertussis-toxin independent manner
Marchant et al., Endocrinology 1989
(Body Weight) :
However, GnRH induced GH and GTH secretion from the goldfish pituitary can occur independently of each other, as demonstrated by the finding that
somatostatin inhibited the
GnRH stimulation of GH secretion in vitro, without influencing the GTH response, whereas the dopamine agonist apomorphine inhibited GnRH induced GTH secretion in vitro, without influencing the GH response
Robbins et al., Brain Res 1985
:
Neurotensin and vasoactive intestinal polypeptide
induced large increases in
somatostatin release, whereas cholecystokinin,
gonadotropin releasing hormone and Met-enkephalin induced only modest increases