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FGF2 — IGF1

Text-mined interactions from Literome

Zhang et al., Lab Invest 1999 (Asthma) : After epithelial perturbation, basic fibroblast growth factor , platelet derived growth factor, IGF-1 , transforming growth factor-beta2, and endothelin-1 levels increased in culture supernatants ... After epithelial perturbation, basic fibroblast growth factor , platelet derived growth factor, IGF-1 , transforming growth factor-beta2, and endothelin-1 levels increased in culture supernatants
Cao et al., Zhonghua Yan Ke Za Zhi 1997 : ( 1 ) EGF, b-FGF , IGF-I significantly increased the DNA 6.6-12.2 times in human RPE cells in comparison with the control, the rank order of potency of the factors being EGF > b-FGF > IGF-I ... ( 1 ) EGF, b-FGF , IGF-I significantly increased the DNA 6.6-12.2 times in human RPE cells in comparison with the control, the rank order of potency of the factors being EGF > b-FGF > IGF-I
Spicer et al., J Anim Sci 2000 : In the presence of insulin, epidermal growth factor, basic fibroblast growth factor , and estradiol decreased ( P < 0.05 ) IGF-I production below that observed for insulin alone
Arsenijevic et al., J Neurosci 2001 : The newly generated spheres were multipotent, and clonal analysis revealed that EGF or FGF-2 , in the presence of IGF-I , acted directly on NSCs
Sun et al., Zhonghua Yan Ke Za Zhi 1999 : Either bFGF ( 1 - 100 microg/L ) or IGF-I ( 20 - 100 microg/L ) increases mitosis of BLEC significantly, and 20 microg/L IGF-I may increase bFGF induced mitogenesis
Chandrasekher et al., Invest Ophthalmol Vis Sci 2003 : The presence of FGF-2 in proliferating rabbit lens epithelial cells enhanced the IGF-1- , but not the PDGF mediated PI-3K activation, suggesting a possible integration of FGF-2 signals with IGF-1
Aberg et al., Mol Cell Neurosci 2003 (MAP Kinase Signaling System) : Pretreatment with fibroblast growth factor-2 (FGF-2) increased the IGF-I receptor (IGF-IR) expression, and both FGF-2 and IGF-I were required for maximal proliferation
Frederick et al., Mol Cell Neurosci 2004 : IGF-I enhanced FGF-2 induction of cyclin D1, activation of G ( 1 ) cyclin-cyclin dependent kinase (cdk) complexes, and hyperphosphorylation of retinoblastoma protein ( pRb )
Russo et al., J Cell Physiol 2004 (Neuroblastoma) : FGF-2 , directly and indirectly, overcomes the proliferative and anti-apoptotic activity of IGF-I by complex mechanisms, including enhancement of differentiation and apoptotic pathways, and inhibition of IGF-I induced anti-apoptotic signalling
Loeser et al., Arthritis Rheum 2005 : Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes ... The anabolic activity of IGF-1 and OP-1, alone and in combination, is significantly inhibited by bFGF
Rosenthal et al., Mol Endocrinol 1991 : Concomitantly, FGF resulted in a 60-70 % increase in IGF-I binding compared to that in control myoblasts ... Scatchard analyses and studies of gene expression demonstrated that the increased IGF-I binding induced by FGF reflected parallel increases in IGF-I receptor content and mRNA abundance
Kalluri et al., Eur J Neurosci 2007 : However, FGF-2 ( ERK activator ) in the presence of IGF-I ( Akt activator ) increased the proliferation of cells ... Accordingly, stimulation of the ERK pathway by FGF-2 induced the expression of cyclin D1, which is essential for the entry of cells into cell cycle, and IGF-I in the presence of FGF-2 up-regulated the expression of cyclin D1
Jeschke et al., Gene Ther 2007 : IGF-I , KGF and their combination cDNA treatment significantly ( P < 0.05 ) accelerated re-epithelization, increased IGF-I, KGF, FGF , VEGF and collagen type IV expression, while it had no effect on collagen type I and III expression
Goldsmith et al., Am J Physiol 1991 : Insulin-like growth factor-1 had no significant effect on bFGF expression
Etheredge et al., Invest Ophthalmol Vis Sci 2009 : The authors suggest that FGF-2 initiates the hypercellular phase of corneal wound healing and that IGF-I and PDGF are involved in the restoration of a normal ECM
Wakabayashi et al., J Neurosci Res 2010 (Brain Ischemia...) : In MSC transplanted brain, among many neurotrophic factors, only human insulin-like growth factor 1 (IGF-1) was detected in the core and ischemic border zone at 3 days after MCAO, whereas host cells expressed markedly higher neurotrophic factors ( rat origin ) than control rats, especially vascular endothelial growth factor ( VEGF ) at 3 days and epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) at 7 days after MCAO
Park et al., Growth Factors 2009 : bFGF also increased the expression of FGFR, which in turn increased expression of insulin-like growth factor ( IGFs )
Fazeli et al., J Clin Endocrinol Metab 2010 : In a transgenic mouse model, FGF-21 reduces IGF-I levels by inhibiting signal transducer and activator of transcription-5, a mediator of the intracellular effects of GH
Naville et al., Mol Cell Endocrinol 1990 : Human chorionic gonadotropin ( hCG ) and basic fibroblast growth factor (FGF) stimulate in a dose dependent manner IGF-I production by Leydig cells ... The secretion of IGF-I by Sertoli cells was stimulated by FSH and FGF
Schulz et al., J Neurosci 2012 : Furthermore, astrocytes in culture express high levels of FGF-2 in response to IL-1ß, and IGF-1 in response to TNF-a stimulation
Kralisch et al., J Endocrinol 2013 (Insulin Resistance) : Notably, FGF21 significantly inhibited IGF1 secretion into HepG2 cell culture supernatants in preliminary in vitro experiments
Penhoat et al., J Biol Chem 1989 : The basal secretion of IGF-I ( 6 +/- 1 ng/48 h/10 ( 6 ) cells ) was stimulated 3-, 4.5-, and 9.5-fold by fibroblast growth factor , angiotensin II ( A-II ), and ACTH, respectively, but not by growth hormone
Wilkie et al., Growth Regul 1995 : This study describes the effect of acidic and basic fibroblast growth factor (FGF) on DNA synthesis in chick satellite cells in vitro and interactions with insulin-like growth factor-I (IGF-I) and exogenous heparin
Johnson et al., Exp Cell Res 1995 : In addition, specific binding of FGF2 to 48-h cultures of adult satellite cells was not stimulated by FGF2, IGF-1 , IGF-2, PDGF-BB, or TGF-beta 2, and specific binding was significantly decreased ( P < 0.05 ) by FGF2 and TGF-beta 2 ... In addition, specific binding of FGF2 to 48-h cultures of adult satellite cells was not stimulated by FGF2, IGF-1 , IGF-2, PDGF-BB, or TGF-beta 2, and specific binding was significantly decreased ( P < 0.05 ) by FGF2 and TGF-beta 2
Canalis et al., Endocrinology 1993 : We tested the effects of basic fibroblast growth factor (bFGF) , transforming growth factor-beta 1 ( TGF beta 1 ), and platelet derived growth factors (PDGF) AA and BB on IGF-I mRNA expression and polypeptide concentrations in cultures of osteoblast enriched ( Ob ) cells from 22-day-old fetal rat calvariae
Ververis et al., Circ Res 1993 : PDGF and FGF but not Ang II regulate vascular IGF I receptors through a PKC dependent pathway
Schriever et al., Atherosclerosis 1996 : Human recombinant insulin-like growth factor I and -II stimulate the expression of basic fibroblast growth factor but suppress the division of bovine coronary smooth muscle cells
Scheinowitz et al., Int J Cardiol 1997 (Disease Models, Animal...) : IGF has been found to promote physiological forms of cardiac hypertrophy, and FGF induces neovascularization
Kanzaki et al., Mol Cell Endocrinol 1994 : Basic fibroblast growth factor induces luteinizing hormone receptor expression in the presence of insulin-like growth factor-I in ovarian granulosa cells
Li et al., Exp Eye Res 1999 (Second Messenger Systems) : The regulation of IGF-I mRNA expression by bFGF was investigated in cultured rat Müller cells and the mechanism of regulation studied ... SQ22536 ( 100 microM ), an adenylate cyclase inhibitor, and H-89, a PKA inhibitor, had no inhibitory effect on bFGF induced down-regulation of IGF-I expression