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ICAM1 — VEGFA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
ICAM1
→
VEGFA
(increases)
Evidence: VEGF may also cause an impairment of leukocyte interactions with the endothelium via the ability of endogenous NO synthesis to inhibit leukocyte rolling and adhesion and upregulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1
Text-mined interactions from Literome
Lu et al., Invest Ophthalmol Vis Sci 1999
:
VEGF increases retinal vascular
ICAM-1 expression in vivo ... The
effect of
VEGF on retinal vascular
ICAM-1 expression was determined in ICAM-1 immunofluorescence studies of retinal flat-mounts and in RNase protection assays ...
VEGF increased capillary endothelial cell
ICAM-1 levels in a dose- and time dependent manner ( 6-24 hours, plateau after 6 hours ; EC50, 25 ng/ml ) ...
VEGF increases retinal vascular
ICAM-1 expression ...
VEGF induced increases in
ICAM-1 may promote retinal leukostasis in diabetic eyes
Fonsatti et al., Cancer Immunol Immunother 1999
(Melanoma) :
Altogether, our results suggest that ( i ) the extent of sICAM-1 release is distinctive for individual melanomas and can be independent of ICAM-1 expression; (ii) tumor endothelia may sustain levels of sICAM-1 in selected melanomas ; ( iii ) melanoma released
VEGF does not
affect ICAM-1 expression and sICAM-1 release by HUVEC
Kikuchi et al., Nihon Rinsho Meneki Gakkai Kaishi 2000
:
The expression of
ICAM-1 and E-selectin induced by TNF-alpha was not
inhibited by either bFGF or
VEGF
Kim et al., J Biol Chem 2001
:
Here we examined the mechanisms underlying
VEGF stimulated expression of
intercellular adhesion molecule 1 ( ICAM-1 ), vascular cell adhesion molecule 1 ( VCAM-1 ), and E-selectin in human umbilical vein endothelial cells ...
VEGF ( 20 ng/ml )
increased expression of
ICAM-1 , VCAM-1, and E-selectin mRNAs in a time dependent manner ...
VEGF increased VCAM-1 and
ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB dependent manner ... These results suggest that
VEGF stimulated expression of
ICAM-1 , VCAM-1, and E-selectin mRNAs was mainly through NF-kappaB activation with PI 3'-kinase mediated suppression, but was independent of nitric oxide and MEK
Zhang et al., J Leukoc Biol 2001
:
Stimulation of human umbilical vein endothelial cells by
VEGF or bFGF for 18 h
up-regulated intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 expression and significantly increased PMNL adhesion and TEM in response to complement fragment 5a ( C5a ) or interleukin (IL)-8
Kim et al., Circ Res 2001
:
In the present study, we used human umbilical vascular endothelial cells ( HUVECs ) to examine the effect of Ang1 on
VEGF induced expression of three adhesion molecules :
intercellular adhesion molecule-1 ( ICAM-1 ), vascular cell adhesion molecule-1 ( VCAM-1 ), and E-selectin ... In the present study, we used human umbilical vascular endothelial cells ( HUVECs ) to examine the effect of Ang1 on
VEGF induced expression of three adhesion molecules
: intercellular adhesion molecule-1 ( ICAM-1 ), vascular cell adhesion molecule-1 ( VCAM-1 ), and E-selectin
Joussen et al., Am J Pathol 2002
(Diabetes Mellitus, Experimental...) :
Retinal
vascular endothelial growth factor induces
intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo ... Taken together, these data demonstrate that
VEGF induces retinal
ICAM-1 and eNOS expression and initiates early diabetic retinal leukocyte adhesion in vivo
Ishida et al., Invest Ophthalmol Vis Sci 2003
(Diabetes Mellitus, Experimental...) :
Compared with VEGF ( 120 ),
VEGF ( 164 ) more potently
increased retinal
ICAM-1 levels ( 2.2-fold ), leukostasis ( 1.9-fold ), and BRB breakdown ( 2.1-fold, P < 0.01 for all ), despite negligible differences in vitreoretinal VEGF levels at the time of evaluation ( P > 0.05 )
Kim et al., Arterioscler Thromb Vasc Biol 2003
(Vasculitis) :
AM inhibited the
VEGF induced protein and mRNA expression of
ICAM-1 , VCAM-1, and E-selectin ... Thus, AM inhibits
VEGF stimulated
ICAM-1 and VCAM-1 expression through a phosphatidylinositol 3'-kinase/Akt pathway
Yang et al., Life Sci 2003
:
These results proved that both ICAM-1 and
VEGF expressions were enhanced in the macrophage derived foam cells, but
ICAM-1 expression
increased earlier than the up-regulation of VEGF ; low dose of ox-LDL mainly up regulated ICAM-1 expression, while high dose mainly increased the VEGF expression
Mamputu et al., J Leukoc Biol 2004
:
Advanced glycation end-products increase monocyte adhesion to retinal endothelial cells through
vascular endothelial growth factor induced
ICAM-1 expression : inhibitory effect of antioxidants ... Taken together, these data indicate that AGEs increase monocyte adhesion to BRECs and that this effect is mediated through
VEGF induced
ICAM-1 expression
Yamagishi et al., Am J Pathol 2004
(Melanoma, Experimental...) :
Furthermore, minodronate inhibited the
VEGF induced expression of
intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in endothelial cells
Chen et al., Invest Ophthalmol Vis Sci 2005
:
Stimulation of hRVECs with
VEGF ( 165 ), TNFalpha, or IL-1beta for 6 to 24 hours
caused significant induction of
intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression
Goebel et al., Am J Physiol Gastrointest Liver Physiol 2006
(Inflammatory Bowel Diseases) :
ICAM-1 adhesion molecule expression on colonic microvascular endothelium also was determined in
response to
VEGF-A stimulation, along with characterization of leukocyte adhesion molecule expression
Zittermann et al., J Leukoc Biol 2006
(Dermatitis) :
With the potent TNF-alpha + IFN-gamma stimulus, in contrast to bFGF,
VEGF did not
enhance E-selectin or
ICAM-1 expression
Stannard et al., Arterioscler Thromb Vasc Biol 2007
(Atherosclerosis...) :
VEGF alone
caused no significant induction of vascular cell adhesion molecule-1,
intercellular adhesion molecule-1 , or E-selectin compared with tumor necrosis factor-alpha
Valcárcel et al., Journal of translational medicine 2008
(Colorectal Neoplasms...) :
More importantly, spheroid derived CT26 cells increased lymphocyte function associated antigen ( LFA ) -1-expressing cell fraction by 3-fold ; and soluble
intercellular adhesion molecule (ICAM)-1 , given to spheroid cultured CT26 cells, further
increased VEGF secretion by 90 %, via cyclooxygenase (COX)-2 dependent mechanism