Ohta et al., Cancer Res 2005
(Stomach Neoplasms) :
These findings suggest that the overexpression of Shh contributes to constitutive Hh activation and that this signaling pathway negatively regulates p21/CIP1 through a Gli1 dependent and p53 independent mechanism in gastric carcinoma cells
Nishimori et al., J Biol Chem 2012
(Bone Neoplasms...) :
In mouse stromal MC3T3-E1 cells, SHH up-regulated the expression of activin receptor IIB (ActR-IIB) and Smad1, which in turn enhanced BMP-responsive reporter activities in these cells