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GNRH1 — PYY

Text-mined interactions from Literome

Pinilla et al., Am J Physiol Endocrinol Metab 2006 : The major findings of our study are 1 ) the stimulatory effect of central administration of PYY- ( 3-36 ) on LH secretion was significantly enhanced after fasting and blocked by a GnRH antagonist ; 2 ) besides central effects, PYY- ( 3-36 ) elicited LH and FSH secretion directly at the pituitary level, a response that is also augmented by fasting ; 3 ) PYY- ( 3-36 ) inhibited GnRH secretion by hypothalamic fragments from male rats fed ad libitum, whereas a significant stimulatory effect was observed after fasting ; and 4 ) the increase in the gonadotropin responsiveness to PYY- ( 3-36 ) in fasting was not associated with changes in the expression of Y2 and Y5 receptor genes at hypothalamus and/or pituitary
Lloyd et al., J Clin Endocrinol Metab 2010 : Peptide YY (PYY) is an anorexigenic hormone that is high in anorexia nervosa and low in obesity, inhibits GnRH secretion, and is suppressed by GH administration
Miura et al., Am J Physiol 1994 (Neuroblastoma) : Dynorphin A and LHRH inhibited the binding of NPY/PYY to SK-N-MC cell membranes at concentrations ranging from 10 ( -7 ) to 10 ( -5 ) M, whereas dynorphin A and CRF were effective in SMS-MSN cells