◀ Back to IFNG

CYBB — IFNG

Text-mined interactions from Literome

Conte et al., J Interferon Cytokine Res 1999 (Granulomatous Disease, Chronic...) : In chronic granulomatous disease , interferon-gamma (IFN-gamma) significantly reduces the incidence and severity of recurrent infections, but its effectiveness administered ex novo during acute infection has been reported in only one case
Eklund et al., J Immunol 1999 : Recruitment of CREB binding protein by PU.1, IFN-regulatory factor-1, and the IFN consensus sequence binding protein is necessary for IFN-gamma induced p67phox and gp91phox expression ... Previously, we identified a CYBB cis element, necessary for IFN-gamma induced gp91phox expression, and also activated by this transcription factor combination ... Because IFN-gamma induces simultaneous expression of p67phox and gp91phox , these investigations identify a molecular event that coordinates oxidase gene transcription during the inflammatory response
Dusi et al., Eur J Immunol 2001 : Our results indicate that in monocytes the IFN-gamma- and TNF-alpha induced expression of gp91phox and p22phox, but not p47phox, requires the binding of PU.1 to gp91phox promoter
Kumatori et al., J Biol Chem 2002 : Cooperation of STAT-1 and IRF-1 in interferon-gamma induced transcription of the gp91(phox) gene ... Interferon (IFN)-gamma induces the expression of the gp91(phox) gene both during myeloid differentiation and also in mature phagocytes through several cis-elements and their binding proteins ... These results demonstrate a new mechanism for IFN-gamma induced transcription of the gp91(phox) gene by the cooperation of STAT-1alpha and IRF-1 binding to -100GAS and -88ISRE, respectively
Lopez et al., J Interferon Cytokine Res 2003 : The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage
Mazzi et al., J Immunol 2004 : IFN-gamma induces gp91phox expression in human monocytes via protein kinase C-dependent phosphorylation of PU.1 ... We previously reported that the stimulation of human blood monocytes with IFN-gamma induces the binding of PU.1 to the gp91(phox) promoter and the consequent expression of gp91(phox) ... This phosphorylation, as well as the IFN-gamma induced PU.1 binding and gp91(phox) protein synthesis, is slightly affected by the casein kinase II inhibitor, daidzein, but is abrogated by the protein kinase C (PKC) -alpha and -beta inhibitor, Go6976, and by synthetic peptides with sequences based on the endogenous pseudosubstrate region of the classical PKC alpha and beta isoforms ... Finally, nuclear run-on assays demonstrated that while the PKC inhibitors, Go6976 and LY333531, decrease the IFN-gamma induced gp91(phox) transcription, the serine phosphatase inhibitor, okadaic acid, enhances the gp91(phox) gene transcription ... Our results indicate that in cultured monocytes, IFN-gamma induces the binding of PU.1 to the gp91(phox) promoter and the expression of gp91(phox) by phosphorylation of PU.1 via activation of PKC alpha and/or beta I
Kakar et al., J Leukoc Biol 2005 : In these studies, we determine Janus tyrosine kinase 2 (JAK2) activation is necessary and sufficient for IFN-gamma induced CYBB transcription in phagocytic cells and also for ICSBP and HoxA10 tyrosine phosphorylation ... Therefore, these findings provide direct demonstration of JAK2 dependence of IFN-gamma induced CYBB transcription
Almeida et al., J Interferon Cytokine Res 2005 : The aim of this work was to analyze the effect of Interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in human colostrum macrophages ( CM ), peripheral blood monocytes ( PBM ), and myelomonocytic THP-1 cells ... Thus, IFN-gamma and TNF-alpha induced equivalent gp91-phox gene expression in THP-1 cells compared with CM or PBM but did not bring about equivalent NADPH oxidase activity
Lindsey et al., J Immunol 2005 : In response to IFN-gamma , phosphorylation of two tyrosine residues in the HoxA10 homeodomain decreases binding to CYBB promoter, thereby abrogating HoxA10 mediated repression
Anrather et al., J Biol Chem 2006 : In monocytic and microglial cell lines, the expression of the NADPH oxidase subunit gp91(phox) was induced by lipopolysaccharide/interferon gamma treatment and was inhibited in cells constitutively expressing IkappaBalpha
Dohi et al., Journal of neuroinflammation 2010 (Brain Injuries) : In the presence of IFNgamma , BV-2 cells had increased inducible nitric oxide synthase and nitric oxide levels, consistent with a classical activated phenotype, and drastically increased expression of gp91phox
Cassatella et al., J Biol Chem 1990 : These results suggest that induction of the gp91-phox gene and protein product by IFN-gamma or LPS is an important requirement in the mechanism of the enhancement of neutrophil and macrophage oxidative metabolism
Cassatella et al., J Clin Invest 1989 (Granulomatous Disease, Chronic...) : Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells
Eklund et al., J Immunol 1996 : Characterization of three promoter elements and cognate DNA binding protein ( s ) necessary for IFN-gamma induction of gp91-phox transcription
Eklund et al., J Biol Chem 1997 (Leukemia, Myeloid) : CYBB is transcriptionally inactive until the promyelocyte stage of myelopoiesis, and in mature phagocytes, expression of gp91(phox) is further increased by interferon-gamma (IFN-gamma) and other inflammatory mediators
Eklund et al., J Biol Chem 1998 : An element in the proximal CYBB promoter binds a protein complex, referred to as hematopoiesis associated factor ( HAF1 ), that is necessary for interferon-gamma (IFNgamma) induced gp91(phox) expression