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CX3CL1 — IFNG

Text-mined interactions from Literome

Imaizumi et al., Tohoku J Exp Med 2000 : Interferon-gamma stimulates the expression of CX3CL1/fractalkine in cultured human endothelial cells
Matsumiya et al., Exp Cell Res 2001 (Inflammation) : sIL-6R markedly inhibited HUVEC fractalkine/CX3CL1 expression induced by interleukin (IL)-1alpha, tumor necrosis factor (TNF)-alpha, or interferon (IFN)-gamma
Ludwig et al., J Immunol 2002 : Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity
Hatakeyama et al., Inflammation 2004 : Heparin inhibits IFN-gamma induced fractalkine/CX3CL1 expression in human endothelial cells ... IFN-gamma is a proinflammatory cytokine that plays a pivotal role in immune and inflammatory responses ; and in endothelial cells, it regulates the expression of fractalkine/CX3CL1 that is a potent agonist for the chemotaxis and adhesion of monocytes and lymphocytes
Bhavsar et al., FASEB J 2008 : We show, in lung A549 epithelial cells, that the tumor necrosis factor-alpha (TNF-alpha) and IFNgamma synergistically induced protein release and mRNA expression of CX(3)CL1 is inhibited by dexamethasone, without interfering with cytokine induced nuclear translocation of NF-kappaB, and by an inhibitor of IkappaB kinase 2, AS602868
Ishida et al., J Immunol 2008 (Disease Models, Animal...) : Furthermore, CX3CL1 enhanced the gene expression of IL-1beta, TNF-alpha, IFN-gamma , and IL-12 by WT macrophages with NF-kappaB activation
Matsumiya et al., J Immunol 2010 : CX3CL1/fractalkine , a chemokine specific to monocytes and NK cells, is induced synergistically by TNF-alpha and IFN-gamma in vascular endothelial cells ... Brief exposure of HUVECs to TNF-alpha led to a robust increase in IFN-gamma induced CX3CL1 production ... CX3CL1 expression is under control of posttranscriptional regulation, which is involved in the synergistic induction of CX3CL1 in response to the combined stimulation with TNF-alpha and IFN-gamma
Isozaki et al., Journal of inflammation research 2008 : Synergistic induction of CX3CL1 by TNF alpha and IFN gamma in osteoblasts from rheumatoid arthritis : involvement of NF-kappa B and STAT-1 signaling pathways