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MAGEA6 — TP53
Text-mined interactions from Literome
Marcar et al., Cancer Res 2010
(Bone Neoplasms...) :
These data suggest that
Mage-A may
block the association of
p53 with its cognate sites in chromatin ... Consistent with this idea, silencing of
Mage-A expression leads to upregulation of several p53-responsive genes in a p53 dependent manner and
stimulates by several fold the interaction of
p53 with the p21, MDM2, and PUMA promoters
Weeraratne et al., Neuro Oncol 2011
(Cerebellar Neoplasms...) :
This decrease in
MAGE-A results in a concomitant increase in
p53 and its associated transcriptional targets, p21/WAF1/CIP1 and, importantly, miR-34a