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DNMT1 — TP53

Pathways - manually collected, often from reviews:

• FastForward regulation: TP53 → DNMT1 (transcriptional regulation, decrease) Peterson et al., Cancer Res 2003*
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: DNMT1 — TP53 (physical association, affinity chromatography technology) Palii et al., Mol Cell Biol 2008*

Text-mined interactions from Literome

Peterson et al., Cancer Res 2003 : p53 mediated repression of DNA methyltransferase 1 expression by specific DNA binding
Qayum et al., J Ayub Med Coll Abbottabad 2006 (Lymphoma) : Increased DNMT1 gene activity may contribute to increased p53 gene expression in human lymphomas, supporting a mutagenic role for the DNMT1 gene
Lin et al., Cancer Res 2010 (Lung Neoplasms) : Here, we showed that wild-type p53 negatively regulated DNMT1 expression by forming a complex with specificity protein 1 (Sp1) protein and chromatin modifiers on the DNMT1 promoter ... Low level of exogenous Sp1 enhanced the repressive activity of endogenous p53 on the DNMT1 promoter whereas high level of Sp1 upregulated DNMT1 gene expression level in A549 ( p53 wild-type ) cells
Georgia et al., Genes Dev 2013 : DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis