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Charest et al., Cell Signal 2007 : The V2 vasopressin receptor (V2R) activates the mitogen activated protein kinases ( MAPK) ERK1/2 through a mechanism involving the scaffolding protein beta arrestin ... Here we report that this activating pathway is independent of G alpha s, G alpha i, G alpha q or G betagamma and that the V2R mediated activation of G alpha s inhibits ERK1/2 activity in a cAMP/PKA dependent manner ... Based on the use of selective pharmacological inhibitors, dominant negative mutants and siRNA, we conclude that the beta arrestin dependent activation of ERK1/2 by the V2R involves c-Src and a metalloproteinase dependent trans-activation event
Oligny-Longpré et al., Proc Natl Acad Sci U S A 2012 : Stimulation of the V2 vasopressin receptor (V2R) in cultured cells or in vivo in rat kidney medullar collecting ducts led to the activation of ERK1/2 through the metalloproteinase mediated shedding of a factor activating the insulin-like growth factor receptor ( IGFR ) ... Given the role that V2R stimulated ERK1/2 plays in kidney cell proliferation, this transactivation mechanism may have important implications for renal pathophysiology